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公开(公告)号：US11203591B2
公开(公告)日：2021-12-21
申请号：US16669346
申请日：2019-10-30
发明人： Gayatri Balan , Mark J. Bartlett , Jayaraman Chandrasekhar , Julian A. Codelli , John H. Conway , Jennifer L. Cosman , Rao V. Kalla , Zachary A. Kasun , Musong Kim , Seung H. Lee , Jennifer R. Lo , Jennifer A. Loyer-Drew , Scott A. Mitchell , Thao D. Perry , Gary B. Phillips , Patrick J. Salvo , Sundaramoorthi Swaminathan , Joshua J. Van Veldhuizen , Suet C. Yeung , Jeff Zablocki
IPC分类号： C07D471/04 , A61K31/437 , C07D519/00
摘要： The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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公开(公告)号：US20230013585A1
公开(公告)日：2023-01-19
申请号：US17331900
申请日：2021-05-27
发明人： Gayatri Balan , Mark J. Bartlett , Jayaraman Chandrasekhar , Julian A. Codelli , John H. Conway , Jennifer L. Cosman , Rao V. Kalla , Musong Kim , Seung H. Lee , Jennifer R. Lo , Jennifer A. Loyer-Drew , Scott A. Mitchell , Thao D. Perry , Gary B. Phillips , Patrick J. Salvo , Joshua J. Van Veldhuizen , Suet C. Yeung , Jeff Zablocki
IPC分类号： A61K31/4545 , A61K31/444 , A61K31/5386 , C07D471/04 , C07D519/00
摘要： The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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公开(公告)号：US20220213091A1
公开(公告)日：2022-07-07
申请号：US17522628
申请日：2021-11-09
发明人： Gayatri Balan , Mark J. Bartlett , Jayaraman Chandrasekhar , Julian A. Codelli , John H. Conway , Jennifer L. Cosman , Rao V. Kalla , Zachary A. Kasun , Musong Kim , Seung H. Lee , Jennifer R. Lo , Jennifer A. Loyer-Drew , Scott A. Mitchell , Thao D. Perry , Gary B. Phillips , Patrick J. Salvo , Sundaramoorthi Swaminathan , Joshua J. Van Veldhuizen , Suet C. Yeung , Jeff Zablocki
IPC分类号： C07D471/04 , C07D519/00
摘要： The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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公开(公告)号：US20240287061A1
公开(公告)日：2024-08-29
申请号：US18543272
申请日：2023-12-18
发明人： Gayatri Balan , Mark J. Bartlett , Jayaraman Chandrasekhar , Julian A. Codelli , John H. Conway , Jennifer L. Cosman Ellis , Rao V. Kalla , Zachary A. Kasun , Musong Kim , Seung H. Lee , Jennifer R. Lo , Jennifer A. Loyer-Drew , Scott A. Mitchell , Thao D. Perry , Gary B. Phillips , Patrick J. Salvo , Sundaramoorthi Swaminathan , Joshua J. Van Veldhuizen , Suet C. Yeung , Jeff Zablocki
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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公开(公告)号：US11453681B2
公开(公告)日：2022-09-27
申请号：US16880134
申请日：2020-05-21
发明人： Evangelos Aktoudianakis , Jayaraman Chandrasekhar , Julian A. Codelli , John H. Conway , Kristyna M. Elbel , Rao V. Kalla , Samuel E. Metobo , Scott A. Mitchell , Thao D. Perry , Scott P. Simonovich , Christopher A. Ziebenhaus
IPC分类号： C07D498/04 , C07D413/14 , C07D471/04 , C07D519/00
摘要： The present disclosure relates generally to certain ene-oxindole compounds, pharmaceutical compositions comprising thereof. Also disclosed are methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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公开(公告)号：US20200171020A1
公开(公告)日：2020-06-04
申请号：US16668732
申请日：2019-10-30
发明人： Gayatri Balan , Mark J. Bartlett , Jayaraman Chandrasekhar , Julian A. Codelli , John H. Conway , Jennifer L. Cosman , Rao V. Kalla , Musong Kim , Seung H. Lee , Jennifer R. Lo , Jennifer A. Loyer-Drew , Scott A. Mitchell , Thao D. Perry , Gary B. Phillips , Patrick J. Salvo , Joshua J. Van Veldhuizen , Suet C. Yeung , Jeff Zablocki
IPC分类号： A61K31/4545 , C07D471/04 , A61K31/444 , A61K31/5386 , C07D519/00
摘要： The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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公开(公告)号：US12037342B2
公开(公告)日：2024-07-16
申请号：US17820374
申请日：2022-08-17
发明人： Evangelos Aktoudianakis , Jayaraman Chandrasekhar , Julian A. Codelli , John H. Conway , Kristyna M. Elbel , Rao V. Kalla , Samuel E. Metobo , Scott A. Mitchell , Thao D. Perry , Scott P. Simonovich , Christopher A. Ziebenhaus
IPC分类号： C07D498/04 , C07D413/14 , C07D471/04 , C07D519/00
CPC分类号： C07D498/04 , C07D413/14 , C07D471/04 , C07D519/00
摘要： The present disclosure relates generally to certain ene-oxindole compounds, pharmaceutical compositions comprising thereof. Also disclosed are methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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公开(公告)号：US11925631B2
公开(公告)日：2024-03-12
申请号：US17331900
申请日：2021-05-27
发明人： Gayatri Balan , Mark J. Bartlett , Jayaraman Chandrasekhar , Julian A. Codelli , John H. Conway , Jennifer L. Cosman , Rao V. Kalla , Musong Kim , Seung H. Lee , Jennifer R. Lo , Jennifer A. Loyer-Drew , Scott A. Mitchell , Thao D. Perry , Gary B. Phillips , Patrick J. Salvo , Joshua J. Van Veldhuizen , Suet C. Yeung , Jeff Zablocki
IPC分类号： A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/5386 , C07D471/04 , C07D519/00 , C12Q1/00
CPC分类号： A61K31/4545 , A61K31/444 , A61K31/5386 , C07D471/04 , C07D519/00
摘要： The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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公开(公告)号：US11897878B2
公开(公告)日：2024-02-13
申请号：US17522628
申请日：2021-11-09
发明人： Gayatri Balan , Mark J. Bartlett , Jayaraman Chandrasekhar , Julian A. Codelli , John H. Conway , Jennifer L Cosman , Rao V. Kalla , Zachary A. Kasun , Musong Kim , Seung H. Lee , Jennifer R. Lo , Jennifer A. Loyer-Drew , Scott A. Mitchell , Thao D. Perry , Gary B. Phillips , Patrick J. Salvo , Sundaramoorthi Swaminathan , Joshua J. Van Veldhuizen , Suet C Yeung , Jeff Zablocki
IPC分类号： C07D471/04 , A61K31/437 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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公开(公告)号：US20230183262A1
公开(公告)日：2023-06-15
申请号：US17820374
申请日：2022-08-17
发明人： Evangelos Aktoudianakis , Jayaraman Chandrasekhar , Julian A. Codelli , John H. Conway , Kristyna M. Elbel , Rao V. Kalla , Samuel E. Metobo , Scott A. Mitchell , Thao D. Perry , Scott P. Simonovich , Christopher A. Ziebenhaus
IPC分类号： C07D498/04 , C07D413/14 , C07D471/04 , C07D519/00
CPC分类号： C07D498/04 , C07D413/14 , C07D471/04 , C07D519/00
摘要： The present disclosure relates generally to certain ene-oxindole compounds, pharmaceutical compositions comprising thereof. Also disclosed are methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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