-
公开(公告)号：US11827609B2
公开(公告)日：2023-11-28
申请号：US17399984
申请日：2021-08-11
IPC分类号： C07D239/95 , A61P31/18 , A61P35/00 , A61K31/517 , A61K31/519 , A61K45/06 , C07D471/04 , C07D487/04 , C07D495/04
CPC分类号： C07D239/95 , A61K31/517 , A61K31/519 , A61K45/06 , A61P31/18 , A61P35/00 , C07D471/04 , C07D487/04 , C07D495/04
摘要： This application relates generally to toll like receptor modulator compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR8), and methods of making and using them.
-
公开(公告)号：US11203591B2
公开(公告)日：2021-12-21
申请号：US16669346
申请日：2019-10-30
发明人： Gayatri Balan , Mark J. Bartlett , Jayaraman Chandrasekhar , Julian A. Codelli , John H. Conway , Jennifer L. Cosman , Rao V. Kalla , Zachary A. Kasun , Musong Kim , Seung H. Lee , Jennifer R. Lo , Jennifer A. Loyer-Drew , Scott A. Mitchell , Thao D. Perry , Gary B. Phillips , Patrick J. Salvo , Sundaramoorthi Swaminathan , Joshua J. Van Veldhuizen , Suet C. Yeung , Jeff Zablocki
IPC分类号： C07D471/04 , A61K31/437 , C07D519/00
摘要： The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
-
公开(公告)号：US20190282576A1
公开(公告)日：2019-09-19
申请号：US16254333
申请日：2019-01-22
发明人： Evangelos Aktoudianakis , Gregory Chin , Richard L. Mackman , Samuel E. Metobo , Michael R. Mish , Hyung-Jung Pyun , Jeff Zablocki
IPC分类号： A61K31/517 , C07D471/04 , C07D239/84 , C07D401/04
摘要： The present disclosure relates generally to toll like receptor modulator compounds, such as diamino pyrido[3,2 D] pyrimidine compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR-8), and methods of making and using them.
-
公开(公告)号：US10285990B2
公开(公告)日：2019-05-14
申请号：US15496283
申请日：2017-04-25
发明人： Evangelos Aktoudianakis , Gregory Chin , Richard L. Mackman , Samuel E. Metobo , Michael R. Mish , Hyung-Jung Pyun , Jeff Zablocki
IPC分类号： A61K31/517 , C07D471/04 , C07D239/84 , C07D401/04
摘要： The present disclosure relates generally to toll like receptor modulator compounds, such as diamino pyrido[3,2 D] pyrimidine compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR-8), and methods of making and using them.
-
公开(公告)号：US20190008858A1
公开(公告)日：2019-01-10
申请号：US16005111
申请日：2018-06-11
发明人： Kyla Bjornson , Eda Canales , Jeromy J. Cottell , Kapil K. Karki , Ashley A. Katana , Darryl Kato , Tetsuya Kobayashi , John O. Link , Ruben Martinez , Barton W. Phillips , Hyung-jung Pyun , Michael Sangi , Adam J. Schrier , Dustin Siegel , James G. Taylor , Chinh V. Tran , Teresa A. Trejo Martin , Randall W. Vivian , Zheng-Yu Yang , Jeff Zablocki , Sheila Zipfel
IPC分类号： A61K31/498 , C07K5/08 , A61K31/10 , C07K5/083 , C07D498/22 , C07D498/16 , C07D403/14 , C07D241/36 , A61K45/06 , A61K38/21 , A61K38/06 , C07K5/087 , A61K31/519 , A61K31/506 , A61K31/4985 , A61K31/4745 , A61K31/401 , A61K38/00
CPC分类号： A61K31/498 , A61K31/10 , A61K31/401 , A61K31/4745 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K38/00 , A61K38/06 , A61K38/21 , A61K45/06 , C07D241/36 , C07D403/14 , C07D498/16 , C07D498/22 , C07K5/08 , C07K5/0808 , C07K5/0812 , C07K5/0827 , A61K2300/00
摘要： Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
-
公开(公告)号：US10100058B2
公开(公告)日：2018-10-16
申请号：US15825993
申请日：2017-11-29
发明人： Elfatih Elzein , Rao V. Kalla , Dmitry Koltun , Xiaofen Li , Eric Q. Parkhill , Thao Perry , Scott Preston Simonovich , Jeff Zablocki , Christopher Allen Ziebenhaus
IPC分类号： C07D487/04 , C07D519/00
摘要： The present disclosure relates to compounds that are CaM Kinase inhibitors and to their use in the treatment of various disease states, including atrial fibrillation and myocardial infarction. In particular embodiments, the general structure of the compounds is given by Formula I: wherein R1, R2, R3, R4, R5, R6, R9 and R10 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
-
公开(公告)号：US20180086755A1
公开(公告)日：2018-03-29
申请号：US15692161
申请日：2017-08-31
IPC分类号： C07D471/04 , A61K31/519 , A61K45/06
CPC分类号： C07D471/04 , A61K31/519 , A61K45/06
摘要： This application relates generally to toll like receptor modulator compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR8), and methods of making and using them.
-
公开(公告)号：US09682998B2
公开(公告)日：2017-06-20
申请号：US15188701
申请日：2016-06-21
发明人： Britton Kenneth Corkey , Elfatih Elzein , Michael Graupe , Juan Guerrero , Robert H. Jiang , Rao V. Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Ruben Martinez , Gregory Notte , Eric Q. Parkhill , Thao Perry , Chandrasekar Venkataramani , Jeff Zablocki
IPC分类号： C07D255/04 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/14 , C07D401/14 , A61K31/53 , A61P25/08 , C07D498/10 , C07D498/04 , C07D263/58 , C07D237/32 , C07D239/88 , C07D239/90 , C07D253/08 , C07D265/22 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14 , C07D217/26 , C07D413/12 , C07D279/08 , C07D417/12
CPC分类号： C07D498/10 , C07D217/26 , C07D237/32 , C07D239/88 , C07D239/90 , C07D253/08 , C07D263/58 , C07D265/22 , C07D279/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/12 , C07D403/14 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/04
摘要： The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Q, R1, X1, X2, Y and R2 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
-
公开(公告)号：US09670205B2
公开(公告)日：2017-06-06
申请号：US15059070
申请日：2016-03-02
发明人： Evangelos Aktoudianakis , Gregory Chin , Richard L. Mackman , Samuel E. Metobo , Michael R. Mish , Hyung-jung Pyun , Jeff Zablocki
IPC分类号： C07D471/04
CPC分类号： A61K31/517 , C07D239/84 , C07D401/04 , C07D471/04
摘要： The present disclosure relates generally to toll like receptor modulator compounds, such as diamino pyrido[3,2 D]pyrimidine compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR-8), and methods of making and using them.
-
公开(公告)号：US09617310B2
公开(公告)日：2017-04-11
申请号：US14214477
申请日：2014-03-14
发明人： Kyla L. Bjornson , Kapil K. Karki , John O. Link , Hyung-jung Pyun , Adam J. Schrier , Kirk L. Stevens , James G. Taylor , Randall W. Vivian , Jeff Zablocki , Sheila Zipfel
IPC分类号： C07D498/22 , A61K31/437 , A61K31/519 , A61K31/4985 , A61P31/14 , C07K7/64 , C07D487/00 , C07D487/02 , C07D203/02
CPC分类号： C07K7/64 , A61K31/437 , A61K31/519 , C07D203/02 , C07D487/00 , C07D487/02 , C07D498/22
摘要： Compounds of formula I: or pharmaceutically acceptable salts thereof, wherein the various substituents are defined herein, methods of using said compounds, and pharmaceutical compositions containing said compounds.
-
-
-
-
-
-
-
-
-
搜索结果
94 条记录 (耗时 0.072 秒)
