公开(公告)号：US11897878B2

公开(公告)日：2024-02-13

申请号：US17522628

申请日：2021-11-09

申请人： Gilead Sciences, Inc.

发明人： Gayatri Balan ,  Mark J. Bartlett ,  Jayaraman Chandrasekhar ,  Julian A. Codelli ,  John H. Conway ,  Jennifer L Cosman ,  Rao V. Kalla ,  Zachary A. Kasun ,  Musong Kim ,  Seung H. Lee ,  Jennifer R. Lo ,  Jennifer A. Loyer-Drew ,  Scott A. Mitchell ,  Thao D. Perry ,  Gary B. Phillips ,  Patrick J. Salvo ,  Sundaramoorthi Swaminathan ,  Joshua J. Van Veldhuizen ,  Suet C Yeung ,  Jeff Zablocki

IPC分类号： C07D471/04 ,  A61K31/437 ,  C07D519/00

CPC分类号： C07D471/04 ,  C07D519/00

摘要： The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.