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    Soluble liquid formulations of quinclorac ammonium salts
    5.
    发明申请
    Soluble liquid formulations of quinclorac ammonium salts 审中-公开
    五氯铵盐的可溶性液体制剂

    公开(公告)号：US20150305336A1

    公开(公告)日：2015-10-29

    申请号：US14390448

    申请日：2013-04-02

    申请人： BASF SE

    发明人： Wayne BARTON

    IPC分类号： A01N43/42 ,  A01N33/12 ,  C07C211/62 ,  A01N25/02 ,  A01N57/20 ,  C07D215/02

    CPC分类号： A01N43/42 ,  A01N25/02 ,  A01N33/12 ,  A01N57/20 ,  C07C211/62 ,  C07D215/02 ,  A01N2300/00

    摘要： The present invention relates to soluble liquid (SL) formulations comprising A) quinclorac ammonium salts of formula I; B) a solvent of formula IIa and/or a solvent of formula IIb; and C) at least one further herbicidal active ingredient C selected from the group consisting of c1) to c2): c1) enolpyruvyl shikimate 3-phosphate synthase inhibitors (EPSP inhibitors); and c2) glutamine synthetase inhibitors; including their agriculturally acceptable salts or derivatives; as well as to herbicidal active mixtures comprising at least one quinclorac ammonium salt of formula I and at least one further herbicide C selected from the group consisting of c1) to c2).

    摘要翻译： 本发明涉及可溶性液体（SL）制剂，其包含A）式I的喹草酸铵盐; B）式IIa的溶剂和/或式IIb的溶剂; 和C）至少一种选自c1）至c2）的另外的除草活性成分C：c1）烯醇丙酮酸莽沙鱼磷酸合酶抑制剂（EPSP抑制剂）; 和c2）谷氨酰胺合成酶抑制剂; 包括其农业上可接受的盐或衍生物; 以及包含至少一种式I的氯化亚铵盐的除草活性混合物和至少一种选自c1）至c2）的另外的除草剂C。

    TETRAHYDROQUINOLINE DERIVATIVES
    8.
    发明申请
    TETRAHYDROQUINOLINE DERIVATIVES 有权

    公开(公告)号：US20120202996A1

    公开(公告)日：2012-08-09

    申请号：US13268214

    申请日：2011-10-07

    申请人： Nicole Corine Renée Van Straten ,  Rudolf Gijsbertus Van Someren ,  Jurgen Schulz

    发明人： Nicole Corine Renée Van Straten ,  Rudolf Gijsbertus Van Someren ,  Jurgen Schulz

    IPC分类号： C07D413/02 ,  C07D401/02 ,  C07D215/02

    CPC分类号： C07D215/38 ,  A61K31/47 ,  A61K31/4709 ,  C07D215/08 ,  C07D215/20 ,  C07D215/48

    摘要： The present invention relates to tetrahydroquinoline derivatives having general formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is formyl, (1-6C)alkylcarbonyl or (1-6C)alkylsulfonyl; R2 and R3 are H or (1-4C)alkyl; R4 is phenyl; R5 is (1-4C)alkyl; Y—X is C(O)—O, S(O)2-O, NHC(O)—O, NHC(S)—O, OC(O)—O, bond-O, C(O)—NH, S(O)2-NH, NHC(O)—NH, NHC(S)—NH, OC(O)—NH, bond-NH, NH—C(O), O—C(O), NH—S(O)2, or O—S(O)2 or Y—X is a bond; R6 is H, trifluoromethyl, (1-6C)alkyl, 1- or 2-adamantyl(1-4C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (3-9C)heteroaryl, (3-6C)cycloalkyl, (2-6C)heterocycloalkyl, (1-4C)alkylthio(1-4C)alkyl, (6-10C)aryl(1-4C)alkyl, (3-9C)heteroaryl(1-4C)alkyl, (3-6C)cycloalkyl(1-4C)alkyl, (2-6C)heterocycloalkyl(1-4C)alkyl, R8,R9-aminocarbonyl(1-4C)alkyl, R8,R9-amino(1-4C)alkyl, R8-oxycarbonyl(1-4C)alkyl, R8-oxy(1-4C)alkyl, R8-carbonyl(1-4C)alkyl or (6-10C)aryl; R7 is H, (1-4C)alkyl, (1-4C)alkoxy, halogen, trifluoromethyl, cyano, nitro, hydroxyl; and R8 and/or R9 is H, (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (6-10C)aryl, (3-9C)heteroaryl, (6-10C)aryl(1-4C)alkyl, (3-9C)heteroaryl(1-4C)alkyl, (3-6C)cycloalkyl(1-4C)alkyl, (2-6C)heterocycloalkyl(1-4C)alkyl, (1-4C)(di)alkylamino(1-4C)alkyl, (1-4C)alkoxy(1-4C)alkyl, (1-4C)alkylthio(1-4C)alkyl, (1-4C)alkylcarbonylamino(1-4C)alkyl, (1-4C)alkoxycarbonyl(1-4C)alkyl, (1-4C)alkoxycarbonylamino(1-4C)alkyl, (3-6C)cycloalkyl, (2-6C)heterocycloalkyl, or R8 and R9 may be joined in a (2-6C)heterocycloalkyl ring. The present invention also relates to pharmaceutical compositions comprising said derivatives and the use of these derivatives to control fertility.

    Substituted diaza-spiro-pyridinone derivatives for use in MCH-1 mediated diseases
    9.
    发明授权
    Substituted diaza-spiro-pyridinone derivatives for use in MCH-1 mediated diseases 有权
    用于MCH-1介导的疾病的取代的二氮杂螺 - 吡啶酮衍生物

    公开(公告)号：US08158643B2

    公开(公告)日：2012-04-17

    申请号：US12444878

    申请日：2007-12-04

    申请人： José Ignacio Andrés-Gil ,  Manuel Jesús Alcázar-Vaca ,  Frank Matthias Dautzenberg ,  Joannes Theodorus Maria Linders

    发明人： José Ignacio Andrés-Gil ,  Manuel Jesús Alcázar-Vaca ,  Frank Matthias Dautzenberg ,  Joannes Theodorus Maria Linders

    IPC分类号： A61K31/438 ,  C07D215/02

    CPC分类号： C07D471/10 ,  C07D498/10

    摘要： The present invention concerns aryl and heteroaryl substituted diaza-spiro-pyridinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-1 activity according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are useful for the prevention and/or treatment of psychiatric disorders, including but not limited to anxiety, eating disorders, mood disorders, such as bipolar disorders and depression, psychoses, such as schizophrenia, and sleeping disorders; obesity; diabetes; sexual disorders and neurological disorders.

    摘要翻译： 本发明涉及具有拮抗性黑色素浓缩激素（MCH）活性的芳基和杂芳基取代的二氮 - 螺 - 吡啶酮衍生物，特别是根据通式（I）的MCH-1活性，其药学上可接受的酸或碱加成盐， N-氧化物形式或其季铵盐，其中变量在权利要求1中定义。它还涉及它们的制备方法，包含它们的组合物及其作为药物的用途。 根据本发明的化合物可用于预防和/或治疗精神病学障碍，包括但不限于焦虑，进食障碍，情绪障碍，例如双相性精神障碍和抑郁症，精神病如精神分裂症和睡眠障碍; 肥胖; 糖尿病; 性障碍和神经障碍。