- 专利标题： Substituted 2,4 diamino-quinoline as new medicament for fibrosis, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases
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申请号： US16529072申请日： 2019-08-01
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公开(公告)号： US11261189B2公开(公告)日： 2022-03-01
- 发明人: Philippe Halfon , Firas Bassissi , Sonia Brun , Jérôme Courcambeck , Madani Rachid
- 申请人： Genoscience Pharma
- 申请人地址： FR Marseilles
- 专利权人： Genoscience Pharma
- 当前专利权人： Genoscience Pharma
- 当前专利权人地址： FR Marseilles
- 代理机构： Browdy and Neimark, PLLC
- 优先权： EP18306167 20180905
- 主分类号： A61K31/4709
- IPC分类号： A61K31/4709 ; C07D487/04 ; C07D207/02 ; C07D215/02
摘要：
2-primary amino-4-secondary amino-quinoline derivatives, their manufacture, pharmaceutical compositions comprising them and their use as medicaments are disclosed. The compounds are useful as a medicament in treating and/or decreasing the severity and/or progression and/or preventing fibrosis and/or related diseases, or for use as a medicament in treating, decreasing the severity and/or progression of and/or preventing autophagy and/or related diseases, for inhibiting autophagy flux, and for inhibiting cathepsins B (CTSB), L (CTSL) and/or D (CTSD) and/or related diseases.
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