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公开(公告)号：US11130740B2
公开(公告)日：2021-09-28
申请号：US16608133
申请日：2018-04-24
IPC分类号： C07D265/30 , C07C233/36 , C07C317/28 , C07D241/04 , C07D307/82 , C07D319/18 , C07D407/12
摘要： The present invention includes substituted 2,3-dihydro-1H-indene analogs, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient.
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公开(公告)号：US20210251991A1
公开(公告)日：2021-08-19
申请号：US17050238
申请日：2019-05-14
发明人： Shuai Chen , Andrew G. Cole , Bruce D. Dorsey , Benjamin J. Dugan , Yi Fan , Dimitar B. Gotchev , Ramesh Kakarla , Jorge Quintero , Michael J. Sofia
IPC分类号： A61K31/506 , A61K31/713 , C07D401/14 , C07D471/08 , C07D487/08 , C07D403/14 , A61K31/519 , C07D491/048 , C07D513/04 , C07D403/04 , C07D401/04 , A61K31/4725 , C07D471/04 , C07D413/14 , A61K31/553
摘要： The present disclosure includes substituted 2,2′-bipyrimidinyl compounds, analogues thereof, and compositions comprising the same, which can be used to treat and/or prevent hepatitis B virus (HBV) and/or hepatitis B virus (HBV)-hepatitis D virus (HDV) infection in a patient.
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公开(公告)号：US11013726B2
公开(公告)日：2021-05-25
申请号：US16834577
申请日：2020-03-30
发明人： Laurèn Danielle Bailey , Yingzhi Bi , Shuai Chen , Bruce D. Dorsey , Dimitar B. Gotchev , Richard James Holland , Ramesh Kakarla , Duyan Nguyen , Mark Christopher Wood
IPC分类号： A61K31/4375 , A61P31/20 , A61K9/51 , A61K31/683 , A61K31/7105 , C07D471/14 , C07D491/147 , C07D491/22 , C07D495/14 , C07D513/14 , C07F9/6561
摘要： The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds and compositions of the invention inhibit and/or reduce HBsAg secretion.
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公开(公告)号：US20210052585A1
公开(公告)日：2021-02-25
申请号：US16982842
申请日：2019-03-29
发明人： Yingzhi Bi , Bruce D. Dorsey , Yi Fan , Christopher Brooks Moore , Duyan Nguyen
IPC分类号： A61K31/506 , A61K45/06 , C07D233/26 , C07D239/06 , C07C255/61 , C07D401/12 , C07D401/14 , C07D211/60 , C07C217/58 , A61K31/4164 , A61K31/505 , A61K31/277 , A61K31/4545 , A61K31/444 , A61K31/445 , A61K31/137
摘要： The present invention includes substituted 3,3′bis(phenoxymethyl)-1,1′-biphenyl compounds, analogues thereof, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient.
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公开(公告)号：US20200261432A1
公开(公告)日：2020-08-20
申请号：US16834577
申请日：2020-03-30
发明人： Laurèn Danielle Bailey , Yingzhi Bi , Shuai Chen , Bruce D. Dorsey , Dimitar B. Gotchev , Richard James Holland , Ramesh Kakarla , Duyan Nguyen , Mark Christopher Wood
IPC分类号： A61K31/4375 , C07F9/6561 , C07D513/14 , C07D495/14 , C07D491/22 , C07D491/147 , C07D471/14 , A61K31/7105 , A61K31/683 , A61K9/51 , A61P31/20
摘要： The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds and compositions of the invention inhibit and/or reduce HBsAg secretion.
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公开(公告)号：US20230295115A1
公开(公告)日：2023-09-21
申请号：US18008873
申请日：2021-06-07
发明人： Andrew G. Cole , Bruce D. Dorsey , Benjamin J. Dugan , Yi Fan , Steven G. Kultgen , Eugen F. Mesaros , Michael J. Sofia
IPC分类号： C07D401/12 , A61K45/06 , C07K16/28 , C07D405/12 , C07D471/04 , C07D217/24 , C07D495/04
CPC分类号： C07D401/12 , A61K45/06 , C07K16/2827 , C07D405/12 , C07D471/04 , C07D217/24 , C07D495/04
摘要： The present disclosure includes substituted isoquinolinylmethyl amides, or analogues thereof, and compositions comprising the same, that can be used to treat, ameliorate, and/or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient.
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公开(公告)号：US11098010B2
公开(公告)日：2021-08-24
申请号：US16495794
申请日：2018-03-20
IPC分类号： C07C271/24 , A61K31/27 , A61K45/06 , A61K31/16 , C07C237/48 , A61K31/167 , C07D213/55 , A61K31/4402 , C07D207/267 , C07C313/06 , A61K31/4015 , C07D207/27 , C07D207/06 , A61K31/40 , C07D213/643 , A61K31/44 , C07D213/73 , A61K31/5377 , C07D211/34 , A61K31/445 , C07D471/04 , A61K31/437 , C07D231/20 , A61K31/415 , C07D213/89 , C07D277/24 , A61K31/426 , C07D263/32 , A61K31/42 , C07D215/14 , A61K31/47 , C07D241/12 , A61K31/4965 , C07D239/26 , A61K31/505 , C07D249/08 , A61K31/4196 , C07D265/30 , A61K31/5375 , C07D205/08 , A61K31/397 , C07D279/12 , A61K31/54 , C07C311/10 , A61K31/18 , C07D487/04 , A61K31/519 , C07D409/12 , A61K31/4436 , C07D235/02 , A61K31/4184
摘要： The present invention includes novel substituted bicyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient. In certain embodiments, the compounds and compositions of the invention are capsid inhibitors.
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公开(公告)号：US20210032246A1
公开(公告)日：2021-02-04
申请号：US17046139
申请日：2019-04-11
发明人： Shuai Chen , Bruce D. Dorsey , Dimitar B. Gotchev , Duyan Nguyen , Mahesh Kumar Pallerla , Ganapati Reddy Pamulapati
IPC分类号： C07D471/14
摘要： The present disclosure relates to novel, scalable methods of making substituted tricyclic compounds that are useful to treat and/or prevent HBV and/or HBV-HDV infection and related conditions in a subject.
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9.发明公开公开(公告)号：US20230312481A1
公开(公告)日：2023-10-05
申请号：US18008859
申请日：2021-06-07
发明人： Andrew G. Cole , Bruce D. Dorsey , Benjamin J. Dugan , Yi Fan , Steven G. Kultgen , Eugen F. Mesaros , Michael J. Sofia
IPC分类号： C07D237/32 , C07D403/12 , C07D471/04 , C07D495/04 , C07D417/12 , C07D413/12 , C07D401/12 , A61K45/06
CPC分类号： C07D237/32 , A61K45/06 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07B2200/07
摘要： The present disclosure includes certain substituted (phthalazin-1-ylmethyl)ureas, N-(phthalazin-1-ylmethyl)amides, and analogues thereof, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient.
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公开(公告)号：US11702427B2
公开(公告)日：2023-07-18
申请号：US16978117
申请日：2019-03-11
发明人： Shuai Chen , Bruce D. Dorsey , Yi Fan , Dimitar B. Gotchev , Jorge Quintero
IPC分类号： C07D493/04 , C07D215/02 , C07D221/04 , C07D471/04 , C07D493/14
CPC分类号： C07D493/04 , C07D215/02 , C07D221/04 , C07D471/04 , C07D493/14
摘要： The present invention includes in one aspect substituted 2-oxo-1,2,5,6-tetrahydrobenzo[h]quinoline-3-carboxylic acids, analogues thereof, and compositions comprising the same, which can be used to treat and/or prevent hepatitis B virus (HBV) infection and/or hepatitis D virus (HDV) in a patient. In certain embodiments, the invention provides a compound of formula (I), or a salt, solvate, geometric isomer, stereoisomer, tautomer, and any mixtures thereof:
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