公开(公告)号：US20250032473A1

公开(公告)日：2025-01-30

申请号：US18740078

申请日：2024-06-11

Applicant: Gilead Sciences, Inc.

Inventor： Peter A. Blomgren ,  Taryn Campbell ,  Jayaraman Chandrasekhar ,  Christopher T. Clark ,  Julian A. Codelli ,  Kevin S. Currie ,  Jeffrey E. Kropf ,  Yasamin Moazami ,  Nicole Nava ,  Leena Patel ,  Stephane Perreault ,  Jason K. Perry ,  Kassandra F. Sedillo ,  Natalie Seeger ,  Kirk L. Stevens ,  Jennifer Anne Treiberg ,  Suet C. Yeung ,  Zhongdong Zhao

IPC: A61K31/47 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/501 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5355 ,  A61K31/541 ,  A61K45/06 ,  C07D215/14 ,  C07D215/18 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D475/02 ,  C07D487/04 ,  C07D491/04 ,  C07D491/06 ,  C07D491/08 ,  C07D498/10 ,  C07D513/04

Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.

公开(公告)号：US20240408089A1

公开(公告)日：2024-12-12

申请号：US18422704

申请日：2024-01-25

Applicant: Amgen Inc.

Inventor： Haby HENARY ,  James Russell LIPFORD ,  Victor J. CEE

IPC: A61K31/505 ,  A61K9/00 ,  A61K31/53 ,  A61K31/5355 ,  A61K39/00 ,  A61P35/00

Abstract: Provided herein are methods of administering a KRAS G12C inhibitor to a cancer subject.

公开(公告)号：US20240382494A1

公开(公告)日：2024-11-21

申请号：US18648062

申请日：2024-04-26

Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

Inventor： Jun WANG

IPC: A61K31/5355 ,  A61K9/12 ,  A61K9/20 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/506 ,  A61P31/14 ,  C07D215/06 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D471/08 ,  C07D487/06 ,  C12N9/99

Abstract: The invention provides a compound of formula (I): or a salt thereof, R1-R4, and A have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as inhibitors of papain-like protease and as antiviral agents.

公开(公告)号：US20240374602A1

公开(公告)日：2024-11-14

申请号：US18689680

申请日：2022-09-06

Applicant: PTC THERAPEUTICS, INC.

Inventor： Scott J. Barraza ,  Jeffrey K. Trimmer ,  Yong Yu ,  Xiaoyan Zhang

IPC: A61K31/519 ,  A61K31/5355

Abstract: The present description relates to methods of treating neurodegenerative diseases characterized by the accumulation of aberrant forms of the microtubule associated protein Tau (MAPT) using substituted thieno[3,2-d]pyrimidine compounds, forms, and pharmaceutical compositions thereof.

公开(公告)号：US12139470B2

公开(公告)日：2024-11-12

申请号：US17680825

申请日：2022-02-25

Applicant: The Regents of the University of California

Inventor： Adam Robert Renslo ,  Brian Richard Blank ,  Ryan Keith Muir ,  Michael John Evans ,  Poulami Talukder

IPC: C07D323/02 ,  A61K31/341 ,  A61K31/351 ,  A61K31/357 ,  A61K31/496 ,  A61K31/5355 ,  A61K31/553 ,  A61P33/06 ,  C07D405/12 ,  C07D407/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Disclosed herein, inter alia, are trioxolane compounds and methods of using the same for treatment and detection of diseases.

公开(公告)号：US20240342146A1

公开(公告)日：2024-10-17

申请号：US18753671

申请日：2024-06-25

Applicant: LEIUTIS PHARMACEUTICALS LLP

Inventor： Chandrashekhar KOCHERLAKOTA ,  Nagaraju BANDA

IPC: A61K31/439 ,  A61K31/438 ,  A61K31/496 ,  A61K31/5355 ,  A61K31/573 ,  A61K31/675

CPC classification number: A61K31/439 ,  A61K31/438 ,  A61K31/496 ,  A61K31/5355 ,  A61K31/573 ,  A61K31/675

Abstract: The disclosure relates to chemotherapy treatments and in particular, formulations for antiemetic therapy. Parenteral formulations comprising Palonosetron, NK1 receptor antagonist and a corticosteroid is provided. Also provided is a process of preparing such formulations.

公开(公告)号：US20240327393A1

公开(公告)日：2024-10-03

申请号：US18574309

申请日：2022-07-08

Applicant: SIRONAX LTD.

Inventor： Jianguang HAN ,  Zhiyuan ZHANG ,  Weijie HOU ,  Yimin JIANG ,  Yanping XU

IPC: C07D413/12 ,  A61K31/366 ,  A61K31/4035 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/472 ,  A61K31/496 ,  A61K31/498 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5355 ,  A61K31/536 ,  A61K31/538 ,  A61K31/5383 ,  A61K31/5415 ,  A61K31/5513 ,  A61K31/553 ,  C07D209/46 ,  C07D217/04 ,  C07D217/06 ,  C07D263/58 ,  C07D277/82 ,  C07D279/16 ,  C07D311/18 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/08 ,  C07D498/04 ,  C07D498/08

CPC classification number: C07D413/12 ,  A61K31/366 ,  A61K31/4035 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/472 ,  A61K31/496 ,  A61K31/498 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5355 ,  A61K31/536 ,  A61K31/538 ,  A61K31/5383 ,  A61K31/5415 ,  A61K31/5513 ,  A61K31/553 ,  C07D209/46 ,  C07D217/04 ,  C07D217/06 ,  C07D263/58 ,  C07D277/82 ,  C07D279/16 ,  C07D311/18 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/08 ,  C07D498/04 ,  C07D498/08

Abstract: Provided are compounds of Formula I, compositions comprising the same, and methods of using the same, including use in treating various diseases and conditions, e.g., those involving ferroptosis.

公开(公告)号：US12053462B2

公开(公告)日：2024-08-06

申请号：US17379175

申请日：2021-07-19

Applicant: Gilead Sciences, Inc.

Inventor： Peter A. Blomgren ,  Taryn Campbell ,  Jayaraman Chandrasekhar ,  Christopher T. Clark ,  Julian A. Codelli ,  Kevin S. Currie ,  Jeffrey E. Kropf ,  Yasamin Moazami ,  Nicole Nava ,  Leena Patel ,  Stephane Perreault ,  Jason K. Perry ,  Kassandra F. Sedillo ,  Natalie Seeger ,  Kirk L. Stevens ,  Jennifer Anne Treiberg ,  Suet C. Yeung ,  Zhongdong Zhao

IPC: C07D215/02 ,  A61K31/4375 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/501 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5355 ,  A61K31/541 ,  A61K45/06 ,  C07D215/14 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D215/18 ,  C07D401/04 ,  C07D413/04 ,  C07D417/14 ,  C07D475/02 ,  C07D491/04 ,  C07D491/06 ,  C07D491/08 ,  C07D498/10 ,  C07D513/04

CPC classification number: A61K31/47 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/501 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5355 ,  A61K31/541 ,  A61K45/06 ,  C07D215/14 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D215/18 ,  C07D401/04 ,  C07D413/04 ,  C07D417/14 ,  C07D475/02 ,  C07D491/04 ,  C07D491/06 ,  C07D491/08 ,  C07D498/10 ,  C07D513/04

Abstract: The present disclosure provides a compound of Formula (I):




or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.

公开(公告)号：US20240254118A1

公开(公告)日：2024-08-01

申请号：US18391258

申请日：2023-12-20

Applicant: Gilead Sciences, Inc.

Inventor： Megan K. Armstrong ,  Elbert Chin ,  Chienhung Chou ,  Laurent P. Debien ,  Joshua D. Farr ,  Pancham Lal Gupta ,  Chao-I Hung ,  Michael L. Mitchell ,  Prasenjit K. Mukherjee ,  Shaina V. Nguyen ,  Gregory T. Notte ,  Daniel Roa ,  Adam J. Schrier ,  Zheng-Yu Yang

IPC: C07D471/04 ,  A61K31/473 ,  A61K31/4741 ,  A61K31/4743 ,  A61K31/4745 ,  A61K31/4748 ,  A61K31/496 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/5386 ,  A61K31/541 ,  A61K31/55 ,  C07D401/12 ,  C07D491/048 ,  C07D513/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K31/473 ,  A61K31/4741 ,  A61K31/4743 ,  A61K31/4745 ,  A61K31/4748 ,  A61K31/496 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/5386 ,  A61K31/541 ,  A61K31/55 ,  C07D401/12 ,  C07D491/048 ,  C07D513/04 ,  C07D519/00

Abstract: The present disclosure relates generally to compounds that inhibit PRMT5. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through inhibiting PRMT5. The disclosure further relates to the use of the compounds for the treatment of a disease or condition associated with chromosome 9p21 deletion or MTAP null. The disclosure further relates to the use of the compounds for the treatment of cancers.

公开(公告)号：US20240228501A1

公开(公告)日：2024-07-11

申请号：US18553898

申请日：2022-04-20

Applicant: CHANGCHUN GENESCIENCE PHARMACEUTICAL CO., LTD.

Inventor： Yunlong SONG ,  Guangyuan SHEN ,  Peng LIU ,  Manhua LI ,  Lei JIN ,  Guocheng WANG ,  Xinyuan MIAO ,  Yue HUANG

IPC: C07D487/04 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/553 ,  C07D519/00

CPC classification number: C07D487/04 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/553 ,  C07D519/00

Abstract: A compound represented by formula (I), or a stereoisomer, a tautomer, an isotope-labeled form, a nitrogen oxide, a solvate, a polymorph, a pharmaceutically acceptable salt, or a prodrug thereof, a method for preparing the same, and a pharmaceutical composition comprising the same are provided. The compound is a NK-3 receptor antagonist, and may be used for preventing and/or treating depression, anxiety disorder, psychosis, schizophrenia, psychotic disorder, bipolar disorder, cognitive disorder, Parkinson's disease, Alzheimer's disease, attention deficit hyperactivity disorder, pain, convulsion, obesity, inflammatory disease, vomiting, preeclampsia, airway-related disease, reproductive disorder, contraception and sex hormone-dependent disease, gynecological disease-related disease, or menopausal syndrome-related disease.