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公开(公告)号：US20240390338A1
公开(公告)日：2024-11-28
申请号：US18689761
申请日：2022-09-06
Applicant: PTC THERAPEUTICS, INC.
Inventor： Scott J. Barraza , Jeffrey K. Trimmer , Yong Yu , Xiaoyan Zhang
IPC: A61K31/4365 , A61K31/444 , A61K31/497
Abstract: The present description relates to methods of treating neurodegenerative diseases characterized by the accumulation of aberrant forms of the microtubule associated protein Tau (MAPT) using substituted thieno[3,2-b]pyridine compounds, forms, and pharmaceutical compositions thereof.
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公开(公告)号：US20230331725A1
公开(公告)日：2023-10-19
申请号：US18211134
申请日：2023-06-16
Applicant: PTC Therapeutics, Inc.
Inventor： Nadiya Sydorenko , Md Rauful Alam , Lukiana Amedzo , Suresh Babu , Ramil Y. Baiazitov , Scott J. Barraza , Anuradha Bhattacharyya , Gary Mitchell Karp , Nathaniel T. Kenton , Anthony R. Mazzotti , Young-Choon Moon , Nicholas W. Mszar , Jana Narasimhan , Sudipta Pal , Jigar S. Patel , Anthony Turpoff , Matthew G. Woll , Zhenrong Xu , Nanjing Zhang
IPC: C07D471/08 , A61P25/28 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107 , C07D493/08 , C07D498/04
CPC classification number: C07D471/08 , A61P25/28 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107 , C07D493/08 , C07D498/04
Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I) or Formula (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.-
公开(公告)号：US11407753B2
公开(公告)日：2022-08-09
申请号：US16617450
申请日：2018-06-05
Applicant: PTC Therapeutics, Inc.
Inventor： Matthew G. Woll , Lukiana Amedzo , Suresh Babu , Scott J. Barraza , Anuradha Bhattacharyya , Gary Mitchell Karp , Anthony R. Mazzotti , Jana Narasimhan , Jigar Patel , Anthony Turpoff , Zhenrong Xu
IPC: C07D487/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D498/04 , C07D513/04 , C07D519/00
Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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公开(公告)号：US20200165256A1
公开(公告)日：2020-05-28
申请号：US16617450
申请日：2018-06-05
Applicant: PTC Therapeutics, Inc.
Inventor： Matthew G. Woll , Lukiana Amedzo , Suresh Babu , Scott J. Barraza , Anuradha Bhattacharyya , Gary Mitchell Karp , Anthony R. Mazzotti , Jana Narasimhan , Jigar Patel , Anthony Turpoff , Zhenrong Xu
IPC: C07D487/04 , C07D413/14 , C07D401/14 , C07D498/04 , C07D417/14 , C07D519/00 , C07D471/04 , C07D513/04 , C07D491/048
Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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公开(公告)号：US20240374602A1
公开(公告)日：2024-11-14
申请号：US18689680
申请日：2022-09-06
Applicant: PTC THERAPEUTICS, INC.
Inventor： Scott J. Barraza , Jeffrey K. Trimmer , Yong Yu , Xiaoyan Zhang
IPC: A61K31/519 , A61K31/5355
Abstract: The present description relates to methods of treating neurodegenerative diseases characterized by the accumulation of aberrant forms of the microtubule associated protein Tau (MAPT) using substituted thieno[3,2-d]pyrimidine compounds, forms, and pharmaceutical compositions thereof.
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Patent Agency Ranking
公开(公告)号：US20220251098A1
公开(公告)日：2022-08-11
申请号：US17723163
申请日：2022-04-18
Applicant: PTC Therapeutics, Inc.
Inventor： Matthew G. Woll , Lukiana Amedzo , Suresh Babu , Scott J. Barraza , Anuradha Bhattacharyya , Gary Mitchell Karp , Anthony R. Mazzotti , Jana Narasimhan , Jigar Patel , Anthony Turpoff , Zhenrong Xu
IPC: C07D487/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D498/04 , C07D513/04 , C07D519/00
Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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公开(公告)号：US20240382491A1
公开(公告)日：2024-11-21
申请号：US18689624
申请日：2022-09-06
Applicant: PTC THERAPEUTICS, INC.
Inventor： Scott J. Barraza , Jeffrey K. Trimmer , Yong Yu , Xiaoyan Zhang
IPC: A61K31/519
Abstract: The present description relates to methods of treating neurodegenerative diseases characterized by the accumulation of aberrant forms of the microtubule associated protein Tau (MAPT) using substituted pyrrolo[2,3-d]pyrimidine compounds, forms, and pharmaceutical compositions thereof.
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公开(公告)号：US12139499B2
公开(公告)日：2024-11-12
申请号：US17254828
申请日：2019-06-25
Applicant: PTC THERAPEUTICS, INC.
Inventor： Nanjing Zhang , Suresh Babu , Scott J. Barraza , Anuradha Bhattacharyya , Guangming Chen , Gary Mitchell Karp , Andrew J. Kassick , Anthony R. Mazzotti , Young-Choon Moon , Jana Narasimhan , Nadiya Sydorenko , Anthony Turpoff , Matthew G. Woll , Wuming Yan
IPC: C07D519/00 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted benzothiazole compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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公开(公告)号：US11780839B2
公开(公告)日：2023-10-10
申请号：US17040104
申请日：2019-03-27
Applicant: PTC THERAPEUTICS, INC.
Inventor： Nadiya Sydorenko , Md Rauful Alam , Lukiana Amedzo , Suresh Babu , Ramil Y. Baiazitov , Scott J. Barraza , Anuradha Bhattacharyya , Gary Mitchell Karp , Nathaniel T. Kenton , Anthony R. Mazzotti , Young-Choon Moon , Nicholas W. Mszar , Jana Narasimhan , Sudipta Pal , Jigar S. Patel , Anthony Turpoff , Matthew G. Woll , Zhenrong Xu , Nanjing Zhang
IPC: C07D471/08 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107 , C07D493/08 , C07D498/04 , A61P25/28 , C07D401/12
CPC classification number: C07D471/08 , A61P25/28 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107 , C07D493/08 , C07D498/04
Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I) or Formula (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.-
公开(公告)号：US20210284660A1
公开(公告)日：2021-09-16
申请号：US17254828
申请日：2019-06-25
Applicant: PTC THERAPEUTICS, INC.
Inventor： Nanjing Zhang , Suresh Babu , Scott J. Barraza , Anuradha Bhattacharyya , Guangming Chen , Gary Mitchell Karp , Andrew J. Kassick , Anthony R. Mazzotti , Young-Choon Moon , Jana Narasimhan , Nadiya Sydorenko , Anthony Turpoff , Matthew G. Woll , Wuming Yan
IPC: C07D519/00 , C07D417/14 , C07D513/04 , C07D487/04 , C07D471/04
Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted benzothiazole compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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