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公开(公告)号：US20240132509A1
公开(公告)日：2024-04-25
申请号：US18507660
申请日：2023-11-13
Applicant: PTC THERAPEUTICS, INC.
Inventor： Nadiya Sydorenko , Md Rauful Alam , Michael A. Arnold , Suresh Babu , Anuradha Bhattacharyya , Guangming Chen , Aleksey I. Gerasyuto , Gary Mitchell Karp , Andrew J. Kassick , Anthony R. Mazzotti , Young-Choon Moon , Jana Narasimhan , Jigar Patel , Anthony Turpoff , Matthew G. Woll , Wuming Yan , Nanjing Zhang
IPC: C07D487/04 , A61P25/14 , A61P25/28 , C07D491/048 , C07D495/04 , C07D519/00
CPC classification number: C07D487/04 , A61P25/14 , A61P25/28 , C07D491/048 , C07D495/04 , C07D519/00
Abstract: Disclosed are quinoline and quinazoline compounds which modulate the activity of the gated ion channels. Compounds that modulate these gated ion channels are useful in the treatment of diseases and disorders related to pain, inflammation, the neurological system, the gastrointestinal system and genitourinary system. Preferred compounds include quinoline or quinazoline derivatives substituted at the 4-position via N(H), C(O) or O moieties.
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公开(公告)号：US11858941B2
公开(公告)日：2024-01-02
申请号：US17254660
申请日：2019-06-25
Applicant: PTC THERAPEUTICS, INC.
Inventor： Nadiya Sydorenko , Md Rauful Alam , Michael A. Arnold , Suresh Babu , Anuradha Bhattacharyya , Guangming Chen , Aleksey I. Gerasyuto , Gary Mitchell Karp , Andrew J. Kassick , Anthony R. Mazzotti , Young-Choon Moon , Jana Narasimhan , Jigar Patel , Anthony Turpoff , Matthew G. Woll , Wuming Yan , Nanjing Zhang
IPC: C07D487/04 , A61P25/28 , C07D519/00 , A61P25/14 , C07D491/048 , C07D495/04
CPC classification number: C07D487/04 , A61P25/14 , A61P25/28 , C07D491/048 , C07D495/04 , C07D519/00
Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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公开(公告)号：US20210238186A1
公开(公告)日：2021-08-05
申请号：US17254660
申请日：2019-06-25
Applicant: PTC THERAPEUTICS, INC.
Inventor： Nadiya Sydorenko , Md Rauful Alam , Michael A. Arnold , Suresh Babu , Anuradha Bhattacharyya , Guangming Chen , Aleksey I. Gerasyuto , Gary Mitchell Karp , Andrew J. Kassick , Anthony R. Mazzotti , Young-Choon Moon , Jana Narasimhan , Jigar Patel , Anthony Turpoff , Matthew G. Woll , Wuming Yan , Nanjing Zhang
IPC: C07D487/04 , C07D519/00 , C07D495/04 , C07D491/048 , A61P25/28 , A61P25/14
Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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公开(公告)号：US12139499B2
公开(公告)日：2024-11-12
申请号：US17254828
申请日：2019-06-25
Applicant: PTC THERAPEUTICS, INC.
Inventor： Nanjing Zhang , Suresh Babu , Scott J. Barraza , Anuradha Bhattacharyya , Guangming Chen , Gary Mitchell Karp , Andrew J. Kassick , Anthony R. Mazzotti , Young-Choon Moon , Jana Narasimhan , Nadiya Sydorenko , Anthony Turpoff , Matthew G. Woll , Wuming Yan
IPC: C07D519/00 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted benzothiazole compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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公开(公告)号：US20210284660A1
公开(公告)日：2021-09-16
申请号：US17254828
申请日：2019-06-25
Applicant: PTC THERAPEUTICS, INC.
Inventor： Nanjing Zhang , Suresh Babu , Scott J. Barraza , Anuradha Bhattacharyya , Guangming Chen , Gary Mitchell Karp , Andrew J. Kassick , Anthony R. Mazzotti , Young-Choon Moon , Jana Narasimhan , Nadiya Sydorenko , Anthony Turpoff , Matthew G. Woll , Wuming Yan
IPC: C07D519/00 , C07D417/14 , C07D513/04 , C07D487/04 , C07D471/04
Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted benzothiazole compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
