公开(公告)号：US20230201200A1

公开(公告)日：2023-06-29

申请号：US18111421

申请日：2023-02-17

Applicant: PTC Therapeutics, Inc.

Inventor： Suresh Babu ,  Anuradha Bhattacharyya ,  Seongwoo Hwang ,  Minakshi Jani ,  Young-choon Moon ,  Nadiya Sydorenko

IPC: A61K31/506 ,  A61K31/433 ,  C07D403/14 ,  C07D405/14 ,  C07D401/12 ,  C07D417/14 ,  C07D417/04 ,  C07D487/04 ,  C07D401/04 ,  C07D409/14 ,  C07D487/10 ,  C07D237/20 ,  C07D471/10 ,  C07D413/14 ,  C07D487/08 ,  C07D405/12 ,  C07D403/10 ,  C07D471/08 ,  C07D403/12 ,  C07D417/10 ,  C07D401/14 ,  C07D417/12 ,  A61K31/50 ,  A61K31/415 ,  A61P25/28 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/501 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/5513 ,  G01N33/68

CPC classification number: A61K31/506 ,  A61K31/50 ,  A61K31/415 ,  A61K31/433 ,  A61K31/501 ,  A61K31/517 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/5377 ,  A61K31/5513 ,  A61P25/28 ,  C07D237/20 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  G01N33/6896 ,  G01N2800/2835

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington’s disease.





In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington’s disease.

公开(公告)号：US10881658B2

公开(公告)日：2021-01-05

申请号：US16710515

申请日：2019-12-11

Applicant: PTC Therapeutics, Inc.

Inventor： Suresh Babu ,  Anuradha Bhattacharyya ,  Seongwoo Hwang ,  Minakshi Jani ,  Young-choon Moon ,  Nadiya Sydorenko

IPC: C07D401/14 ,  A61K31/506 ,  A61K31/433 ,  C07D403/14 ,  C07D405/14 ,  C07D401/12 ,  C07D417/14 ,  C07D417/04 ,  C07D487/04 ,  C07D401/04 ,  C07D409/14 ,  C07D487/10 ,  C07D237/20 ,  C07D471/10 ,  C07D413/14 ,  C07D487/08 ,  C07D405/12 ,  C07D403/10 ,  C07D471/08 ,  C07D403/12 ,  C07D417/10 ,  C07D417/12 ,  A61K31/50 ,  A61K31/415 ,  A61P25/28 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/501 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/5513 ,  G01N33/68

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：US20200163973A1

公开(公告)日：2020-05-28

申请号：US16625081

申请日：2018-06-27

Applicant: PTC Therapeutics, Inc.

Inventor： Anuradha Bhattacharyya ,  Minakshi B. Jani ,  Matthew G. Woll ,  Nadiya Sydorenko

IPC: A61K31/5513 ,  A61P25/00 ,  A61K31/519 ,  A61K31/5377

Abstract: The present description relates to a method or use of a compound for treating or ameliorating HD (Huntington's Disease) in a subject in need thereof comprising administering to the subject an effective amount of a compound of Formula (I): or a form thereof, wherein w1, w2, w3, w4, w5, w6 and w7 are as defined herein. In particular, the present description relates to a method of use of a compound of Formula (I) or a form or composition thereof for treating or ameliorating HD in a subject in need thereof comprising, administering an effective amount of the compound or a form or composition thereof to the subject.

公开(公告)号：US10370371B2

公开(公告)日：2019-08-06

申请号：US14914909

申请日：2013-11-21

Applicant: PTC Therapeutics, Inc.

Inventor： Wu Du ,  Ramil Baiazitov ,  Chang-Sun Lee ,  Young-Choon Moon ,  Steven D. Paget ,  Hongyu Ren ,  Nadiya Sydorenko ,  Richard Gerald Wilde

IPC: A61K45/06 ,  A61K31/506 ,  C07D401/04 ,  C07D403/04 ,  C07D471/04

Abstract: Amine substituted pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.

公开(公告)号：US12139499B2

公开(公告)日：2024-11-12

申请号：US17254828

申请日：2019-06-25

Applicant: PTC THERAPEUTICS, INC.

Inventor： Nanjing Zhang ,  Suresh Babu ,  Scott J. Barraza ,  Anuradha Bhattacharyya ,  Guangming Chen ,  Gary Mitchell Karp ,  Andrew J. Kassick ,  Anthony R. Mazzotti ,  Young-Choon Moon ,  Jana Narasimhan ,  Nadiya Sydorenko ,  Anthony Turpoff ,  Matthew G. Woll ,  Wuming Yan

IPC: C07D519/00 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted benzothiazole compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：US11780839B2

公开(公告)日：2023-10-10

申请号：US17040104

申请日：2019-03-27

Applicant: PTC THERAPEUTICS, INC.

Inventor： Nadiya Sydorenko ,  Md Rauful Alam ,  Lukiana Amedzo ,  Suresh Babu ,  Ramil Y. Baiazitov ,  Scott J. Barraza ,  Anuradha Bhattacharyya ,  Gary Mitchell Karp ,  Nathaniel T. Kenton ,  Anthony R. Mazzotti ,  Young-Choon Moon ,  Nicholas W. Mszar ,  Jana Narasimhan ,  Sudipta Pal ,  Jigar S. Patel ,  Anthony Turpoff ,  Matthew G. Woll ,  Zhenrong Xu ,  Nanjing Zhang

IPC: C07D471/08 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D491/107 ,  C07D493/08 ,  C07D498/04 ,  A61P25/28 ,  C07D401/12

CPC classification number: C07D471/08 ,  A61P25/28 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D491/107 ,  C07D493/08 ,  C07D498/04

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.




In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I) or Formula (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：US20210284660A1

公开(公告)日：2021-09-16

申请号：US17254828

申请日：2019-06-25

Applicant: PTC THERAPEUTICS, INC.

Inventor： Nanjing Zhang ,  Suresh Babu ,  Scott J. Barraza ,  Anuradha Bhattacharyya ,  Guangming Chen ,  Gary Mitchell Karp ,  Andrew J. Kassick ,  Anthony R. Mazzotti ,  Young-Choon Moon ,  Jana Narasimhan ,  Nadiya Sydorenko ,  Anthony Turpoff ,  Matthew G. Woll ,  Wuming Yan

IPC: C07D519/00 ,  C07D417/14 ,  C07D513/04 ,  C07D487/04 ,  C07D471/04

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted benzothiazole compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：US20210024525A1

公开(公告)日：2021-01-28

申请号：US17040104

申请日：2019-03-27

Applicant: PTC THERAPEUTICS, INC.

Inventor： Nadiya Sydorenko ,  Md Rauful Alam ,  Lukiana Amedzo ,  Suresh Babu ,  Ramil Y. Baiazitov ,  Scott J. Barraza ,  Anuradha Bhattacharyya ,  Gary Mitchell Karp ,  Nathaniel T. Kenton ,  Anthony R. Mazzotti ,  Young-Choon Moon ,  Nicholas W. Mszar ,  Jana Narasimhan ,  Sudipta Pal ,  Jigar S. Patel ,  Anthony Turpoff ,  Matthew G. Woll ,  Zhenrong Xu ,  Nanjing Zhang

IPC: C07D471/10 ,  C07D413/14 ,  C07D401/14 ,  C07D471/08 ,  C07D409/14 ,  C07D417/14 ,  C07D487/04 ,  C07D471/04 ,  C07D498/04 ,  C07D405/14 ,  C07D491/107 ,  C07D493/08

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I) or Formula (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：US20160214978A1

公开(公告)日：2016-07-28

申请号：US14914909

申请日：2013-11-21

Applicant: PTC THERAPEUTICS, INC.

Inventor： Wu Du ,  Ramil Baiazitov ,  Chang-Sun Lee ,  Young-Choon Moon ,  Steven D. Paget ,  Hongyu Ren ,  Nadiya Sydorenko ,  Richard Gerald Wilde

IPC: C07D471/04 ,  C07D401/04 ,  A61K45/06 ,  C07D403/04 ,  A61K31/506

CPC classification number: C07D471/04 ,  A61K31/506 ,  A61K45/06 ,  C07D401/04 ,  C07D403/04

Abstract: Amine substituted pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.

Abstract translation: 胺取代的嘧啶化合物及其形式，其抑制B细胞特异性莫洛尼鼠白血病病毒整合位点1（Bmi-1）蛋白的功能和水平的降低及其用于抑制Bmi-1功能和降低Bmi水平的方法 -1治疗由Bmi-1介导的癌症。

公开(公告)号：US20150315182A1

公开(公告)日：2015-11-05

申请号：US14443911

申请日：2013-11-21

Applicant: PTC THERAPEUTICS, INC.

Inventor： Chang-Sun Lee ,  Ramil Baiazitov ,  Liangxian Cao ,  Thomas W Davis ,  Wu Du ,  Ronggang Liu ,  Young-choon Moon ,  Steven D. Paget ,  Hongyu Ren ,  Nadiya Sydorenko ,  Richard Gerald Wilde

IPC: C07D471/04 ,  A61N5/10 ,  C07D403/04 ,  C07D487/04 ,  A61K31/506 ,  A61K45/06

CPC classification number: C07D403/12 ,  A61K31/506 ,  A61K45/06 ,  A61N5/10 ,  C07D403/04 ,  C07D471/04 ,  C07D487/04 ,  Y02A50/411

Abstract: Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.

Abstract translation: 胺取代的反向嘧啶化合物及其形式，其抑制B细胞特异性莫洛尼鼠白血病病毒整合位点1（Bmi-1）蛋白的功能和水平降低，以及用于抑制Bmi-1功能并降低其水平的方法 本文描述了用于治疗由Bmi-1介导的癌症的Bmi-1。