知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

3564 条记录 (耗时 0.061 秒)

    PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS
    1.
    发明申请
    PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS 审中-公开

    公开(公告)号：US20190247383A1

    公开(公告)日：2019-08-15

    申请号：US16195966

    申请日：2018-11-20

    申请人： Tianjin Hemay Bio-Tech Co., Ltd.

    发明人： Hesheng Zhang

    IPC分类号： A61K31/454 ,  C07D401/14 ,  A61K31/445 ,  C07D401/04

    CPC分类号： A61K31/454 ,  A61K31/445 ,  C07D401/04 ,  C07D401/14 ,  Y02A50/411

    摘要： This invention is directed to derivatives of piperidine-2,6-dione, or their organic or inorganic salts thereof, a methods of synthesis of these derivatives, and their application as active pharmaceutical ingredient as inhibitors of TNFα releasing in cells, the derivative of piperidine-2,6-dione being of the general formula (I): wherein n represents 1, 2, 3, 4, 5 or 6; R1 represents from one to four of the same or different substituents selected from F, Cl, Br, C1-4 alkyl, OH, OC1-4 alkyl, NO2, NHC(O)C1-4 alkyl, NH2, NH(C1-4 alkyl), N(C1-4 alkyl)2; R2 represents OR3, NR3R4, N(R3)COR4, O2CR5; R3 and R4 represent independently and at each occurrence H or C1-4 alkyl; R5 represents CHR6NR7R, CHR6NR9C(O)CHR10NR7R8, a heterocycle W or CHR6NR9C(O)W; R6, R9, R10 represent independently and at each occurrence H, or C1-4 alkyl; R7 and R8 represent independently and at each occurrence H, C1-4 alkyl, or R7 and R8 taken together represent 1,3-propylene, 1,4-butylene, 1,5-pentylene, or 1,6-hexylene; W represents four-membered, five-membered, six-membered, seven-membered, or eight-membered saturated or unsaturated heterocycle.