公开(公告)号：US12076438B2

公开(公告)日：2024-09-03

申请号：US17066919

申请日：2020-10-09

申请人： Translate Bio, Inc.

发明人： Christian Cobaugh ,  Richard Wooster ,  Frank DeRosa ,  Anusha Dias ,  Shrirang Karve

IPC分类号： A61K9/127 ,  A61K9/00 ,  A61K38/17 ,  A61K38/19 ,  A61K38/20 ,  A61K45/06 ,  A61P35/00

CPC分类号： A61K9/127 ,  A61K9/0019 ,  A61K9/007 ,  A61K9/0078 ,  A61K38/1709 ,  A61K38/19 ,  A61K38/193 ,  A61K38/208 ,  A61K45/06 ,  A61P35/00

摘要： The present invention provides, among other things, methods and compositions for cancer treatment. The methods and compositions disclosed herein are particularly effective in reducing the size/volume of a tumor and inhibiting tumor growth.

公开(公告)号：US20240238392A1

公开(公告)日：2024-07-18

申请号：US18392662

申请日：2023-12-21

申请人： Penland Foundation

发明人： Roland M. Williams

IPC分类号： A61K38/48 ,  A61K9/00 ,  A61K31/519 ,  A61K31/714 ,  A61K33/00 ,  A61P9/04

CPC分类号： A61K38/4893 ,  A61K9/0019 ,  A61K9/007 ,  A61K9/0085 ,  A61K31/519 ,  A61K31/714 ,  A61K33/00 ,  A61P9/04 ,  C12Y304/24069

摘要： Provided is a method of treating chronic heart failure in a patient in need thereof. The method administering a botulinum toxin to the patient, thereby treating chronic heart failure. Also provided is a method of treating acute heart failure in a patient in need thereof. The method includes administering nitrous oxide and oxygen and B-12 and/or folic acid to the patient, thereby treating acute heart failure.

公开(公告)号：US20240238332A1

公开(公告)日：2024-07-18

申请号：US18230438

申请日：2023-08-04

申请人： Beyond Air LTD

发明人： Yossef Av-Gay ,  Christopher C. Miller ,  David Greenberg

IPC分类号： A61K33/00 ,  A61B5/00 ,  A61B5/083 ,  A61B5/145 ,  A61K9/00 ,  A61M16/00 ,  A61M16/12

CPC分类号： A61K33/00 ,  A61B5/0833 ,  A61B5/0836 ,  A61B5/14507 ,  A61B5/14542 ,  A61B5/4244 ,  A61K9/007 ,  A61M16/0003 ,  A61M16/12 ,  A61M16/122 ,  A61M2202/0007 ,  A61M2202/0275 ,  A61M2205/3303 ,  A61M2230/202 ,  A61M2230/205 ,  A61M2230/207 ,  A61M2230/432

摘要： A method of treating a human subject which is effected by intermittent inhalation of gaseous nitric oxide at a concentration of at least 160 ppm is disclosed. The method can be utilized for treating a human subject suffering from, or prone to suffer from, a disease or disorder that is manifested in the respiratory tract, or from a disease or disorder that can be treated via the respiratory tract. The disclosed method can be effected while monitoring one or more of on-site and off-site parameters such as vital signs, methemoglobin levels, pulmonary function parameters, blood chemistry and hematological parameters, blood coagulation parameters, inflammatory marker levels, liver and kidney function parameters and vascular endothelial activation parameters, such that no substantial deviation from a baseline in seen in one or more of the monitored parameters.

公开(公告)号：US20240173431A1

公开(公告)日：2024-05-30

申请号：US18281122

申请日：2022-03-10

申请人： OREGON STATE UNIVERSITY

发明人： Jeonghwan KIM ,  Anindit MUKHERJEE ,  Gaurav SAHAY

IPC分类号： A61K48/00 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K38/48 ,  A61P31/14

CPC分类号： A61K48/005 ,  A61K9/007 ,  A61K9/1271 ,  A61K9/5123 ,  A61K38/4813 ,  A61P31/14 ,  C12Y304/17023

摘要： Embodiments provide for therapeutic agents and methods of use thereof, for treating one or more diseases or conditions. In one example, the therapeutic agent is a lipid nanoparticle comprised of an ionizable lipid, a PEG lipid, a sterol, and a structural lipid, the lipid nanoparticle including one or more mRNA molecules encoding for a soluble form of human angiotensin-converting enzyme 2 and/or variations thereof. In this way, one or more signs or symptoms of Covid-19 may be treated via use of the therapeutic agent.

公开(公告)号：US11986493B2

公开(公告)日：2024-05-21

申请号：US17540965

申请日：2021-12-02

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Mark Thomas Gladwin ,  Edwin Parsley ,  Hunter Clay Champion

IPC分类号： A61K33/00 ,  A61K9/00 ,  A61K31/04

CPC分类号： A61K33/00 ,  A61K9/007 ,  A61K9/0073 ,  A61K31/04

摘要： Disclosed herein are methods for treating acute or chronic heart failure using inorganic nitrite, such as sodium nitrite. The method includes administering to a subject in need of treatment a therapeutically effective amount of inorganic nitrite. The nitrite may be administered by inhalation and may be nebulized. The nitrite may be administered at an emitted dose or in an escalated titrated dose. The nitrite may be a liquid formulation or a dry powder formulation.

公开(公告)号：US11980219B2

公开(公告)日：2024-05-14

申请号：US17040232

申请日：2019-04-08

申请人： Philip Morris Products S.A.

发明人： Sebastien Capelli ,  Farideh Goudarzi ,  Timothy King ,  Jean-Yves Vollmer ,  Gerard Zuber

IPC分类号： A24B15/16 ,  A24B15/167 ,  A24B15/32 ,  A24B15/40 ,  A61K9/00 ,  A61K9/06 ,  A61K31/465 ,  A61K36/185 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/36 ,  A61K47/46

CPC分类号： A24B15/167 ,  A24B15/32 ,  A24B15/403 ,  A61K9/007 ,  A61K9/06 ,  A61K31/465 ,  A61K36/185 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/36 ,  A61K47/46

摘要： A composition is provided, including a gelling agent forming a solid medium, glycerol dispersed in the solid medium, and nicotine dispersed in the glycerol, the composition being a stable gel phase.

公开(公告)号：US11931487B2

公开(公告)日：2024-03-19

申请号：US17821684

申请日：2022-08-23

申请人： Enviroscent, Inc.

发明人： Eric Mehnert ,  Nicholas D. McKay ,  Bao Trong Do

IPC分类号： A61L9/12 ,  A61K9/00 ,  A61L9/03 ,  A61L9/04 ,  A61M15/08 ,  A61M11/04 ,  A61M21/00

CPC分类号： A61L9/125 ,  A61K9/007 ,  A61L9/032 ,  A61L9/035 ,  A61L9/037 ,  A61L9/042 ,  A61L9/122 ,  A61L9/127 ,  A61M15/08 ,  A61L2209/12 ,  A61L2209/133 ,  A61L2209/15 ,  A61M11/041 ,  A61M2021/0016 ,  A61M2205/02 ,  A61M2205/59 ,  A61M2207/00

摘要： Described are articles formed of a pulp base material comprising fibers, wherein pores are formed between the fibers. A volatile composition with at least one top note component and at least one base note component at least partially fills the pores of the pulp base material. A release rate of the at least one top note component is modulated by the pulp base material, and a release rate of the at least one base note component is enhanced by the pulp base material.

公开(公告)号：US11903942B2

公开(公告)日：2024-02-20

申请号：US18125517

申请日：2023-03-23

申请人： Oyster Point Pharma, Inc.

发明人： Douglas Michael Ackermann, Jr. ,  James Loudin ,  Kenneth J. Mandell

IPC分类号： A61K31/4995 ,  A61K31/4439 ,  A61K45/06 ,  A61K9/00 ,  A61K31/439 ,  A61K31/4427 ,  A61K9/08 ,  A61K31/4985

CPC分类号： A61K31/4995 ,  A61K9/007 ,  A61K9/0043 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/439 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4985 ,  A61K45/06

摘要： Described herein are methods and pharmaceutical formulations for treating dry eye disease.

公开(公告)号：US20240032598A1

公开(公告)日：2024-02-01

申请号：US18366347

申请日：2023-08-07

申请人： Altria Client Services LLC

发明人： Yossef RAICHMAN

IPC分类号： A24F40/42 ,  A24F40/46 ,  A24F40/40 ,  A24F40/57 ,  A24F40/50 ,  A61M11/04 ,  A61M15/00 ,  A61P25/36 ,  A61P27/06 ,  A61P25/30 ,  A61P43/00 ,  A61P11/06 ,  A61P25/18 ,  A61P25/08 ,  A61P29/00 ,  A61P1/08 ,  A61K9/00 ,  A61K31/05 ,  A61K31/352 ,  A61K36/185 ,  A61M15/06

CPC分类号： A24F40/42 ,  A24F40/46 ,  A24F40/40 ,  A24F40/57 ,  A24F40/50 ,  A61M11/042 ,  A61M15/00 ,  A61M15/003 ,  A61P25/36 ,  A61P27/06 ,  A61P25/30 ,  A61P43/00 ,  A61P11/06 ,  A61P25/18 ,  A61P25/08 ,  A61P29/00 ,  A61P1/08 ,  A61K9/007 ,  A61K31/05 ,  A61K31/352 ,  A61K36/185 ,  A61M15/06 ,  A24F40/20

摘要： A method of treating disorders in a human or animal subject may include heating a material containing a compound to a first temperature to form a heated volume of the material. The method may additionally include heating the heated volume to a higher second temperature to form a dose of vapor including the compound. The method may also include administering the dose of vapor to the subject to treat disorders such as pain. The method may further include pre-heating the material to a preliminary temperature prior to the heating to the first temperature. The heating and pre-heating may be performed with a capsule including two covering layers, each including an electrically conductive material, configured to hold the material therebetween and to generate heat by resistive heating.

公开(公告)号：US20230390186A1

公开(公告)日：2023-12-07

申请号：US18234882

申请日：2023-08-17

申请人： Syqe Medical Ltd.

发明人： Perry DAVIDSON ,  Aaron SCHORR ,  Arie HOLTZ ,  Will PONG ,  Binyamin SCHWARTZ

IPC分类号： A61K9/00 ,  A61K9/70 ,  A61M11/04 ,  A61M15/00 ,  A24F40/50

CPC分类号： A61K9/0004 ,  A61K9/007 ,  A61K9/7007 ,  A61M11/041 ,  A61M15/0045 ,  A61M15/0065 ,  A61M11/042 ,  A61M15/0003 ,  A61M15/0016 ,  A61M15/002 ,  A61M15/0051 ,  A61M15/0055 ,  A61M15/0066 ,  A61M15/008 ,  A61M15/0081 ,  A61M15/0083 ,  A24F40/50 ,  A61M11/048 ,  A61M2016/0021

摘要： There is provided in accordance with an exemplary embodiment of the invention, a device and a method for controlled extraction of at least one active substance from at least one type of plant matter by application of heat, the device comprising: a heating element adapted to apply heat to an area of the plant matter to extract the substance; and a mechanism adapted for moving the plant matter relative to the heating element. Optionally, the active substance is a restricted substance. There is also provided in accordance with an exemplary embodiment of the invention, a method of monitoring and controlling inhalation of a restricted substance. There is provided in accordance with an exemplary embodiment of the invention, a method of manufacturing a tape of plant matter comprising an active substance.