公开(公告)号：US12122773B2

公开(公告)日：2024-10-22

申请号：US18326732

申请日：2023-05-31

申请人： Theravance Biopharma R&D IP, LLC

发明人： Gene Timothy Fass

IPC分类号： C07D471/04 ,  A61K9/00 ,  A61P11/06

CPC分类号： C07D471/04 ,  A61K9/0053 ,  A61P11/06 ,  C07B2200/13

摘要： Provided herein is a crystalline hydrate of the compound of formula 1:




Also provides herein are pharmaceutical compositions comprising such crystalline hydrate, methods of using such crystalline hydrate to treat respiratory diseases, and processes useful for preparing such crystalline hydrate.

公开(公告)号：US12098139B2

公开(公告)日：2024-09-24

申请号：US17750165

申请日：2022-05-20

申请人： RAPT Therapeutics, Inc.

发明人： Jeffrey J. Jackson ,  John Michael Ketcham ,  Akinori Okano ,  Maureen Kay Reilly ,  Omar Robles-Resendiz ,  Jacob Bradley Schwarz ,  Parcharee Tivitmahaisoon ,  David Juergen Wustrow ,  Ashkaan Younai ,  Mikhail Zibinsky

IPC分类号： C07D401/14 ,  A61P11/06 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  C07D495/04

CPC分类号： C07D401/14 ,  A61P11/06 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  C07D495/04

摘要： Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of certain chemokine receptor activity.

公开(公告)号：US20240309086A1

公开(公告)日：2024-09-19

申请号：US18651002

申请日：2024-04-30

申请人： Alcea Therapeutics, Inc.

发明人： Fortunato Ferrara

IPC分类号： C07K16/28 ,  A61P11/06

CPC分类号： C07K16/28 ,  A61P11/06 ,  C07K2317/21

摘要： Antibodies specific to Notch4 and related methods of treating conditions such as airway inflammation.

公开(公告)号：US20240294628A1

公开(公告)日：2024-09-05

申请号：US18650526

申请日：2024-04-30

申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

发明人： Myrna A. MONCK ,  Narendra B. BAM ,  Jennifer DALLY ,  Michelle SPATARA

IPC分类号： C07K16/24 ,  A61P11/02 ,  A61P11/06

CPC分类号： C07K16/244 ,  A61P11/02 ,  A61P11/06 ,  C07K2317/24 ,  C07K2317/40 ,  C07K2317/90 ,  C07K2317/94

摘要： The present disclosure relates to compositions for treating interleukin 5 (IL-5) mediated diseases, and related methods.

公开(公告)号：US12077521B2

公开(公告)日：2024-09-03

申请号：US17104081

申请日：2020-11-25

申请人： Janssen Pharmaceutica NV

发明人： Tianbao Lu ,  Brett Douglas Allison ,  Joseph Kent Barbay ,  Peter J. Connolly ,  Maxwell David Cummings ,  Gaston Diels ,  James Patrick Edwards ,  Kevin D. Kreutter ,  Ulrike Philippar ,  Fang Shen ,  Johannes Wilhelmus John Fitzgerald Thuring ,  Tongfei Wu ,  Didier Jean-Claude Berthelot

IPC分类号： C07D401/14 ,  A61P1/00 ,  A61P11/06 ,  A61P19/02 ,  A61P35/00 ,  A61P37/00 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

CPC分类号： C07D401/14 ,  A61P1/00 ,  A61P11/06 ,  A61P19/02 ,  A61P35/00 ,  A61P37/00 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

摘要： Disclosed are compounds, compositions and methods for treating of diseases, syndromes, conditions, and disorders that are affected by the modulation of MALT1. Such compounds are represented by Formula (I) as follows:




wherein R1, R2, R3, R4, R5, R6, R5, G1, and G2 are defined herein.

公开(公告)号：US12070487B2

公开(公告)日：2024-08-27

申请号：US17418684

申请日：2019-12-24

申请人： UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION ,  THE ASAN FOUNDATION

发明人： You Sook Cho ,  Jun Pyo Choi ,  In Jeoung Baek ,  Hyouk Soo Kwon ,  So Young Park

IPC分类号： A61K38/17 ,  A61K45/06 ,  A61P11/06

CPC分类号： A61K38/1709 ,  A61K45/06 ,  A61P11/06

摘要： The present invention relates to a pharmaceutical composition comprising a progesterone-induced blocking factor (PIBF) protein as an active ingredient for prevention or treatment of inflammatory disease. In the present invention, menopausal asthma animal models have been experimentally identified to decrease airway inflammation when treated with PIBF protein. Thus, the composition can be advantageously used in postmenopausal female asthma patients.

公开(公告)号：US20240270743A1

公开(公告)日：2024-08-15

申请号：US18682563

申请日：2022-08-09

申请人： LANDOS BIOPHARMA, INC.

发明人： Josep Bassaganya-Riera ,  Raquel Hontecillas ,  Nuria Tubau-Juni ,  Andrew Leber

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/444 ,  A61P3/10 ,  A61P11/00 ,  A61P11/06

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/444 ,  A61P3/10 ,  A61P11/00 ,  A61P11/06

摘要： Tetrahydropyrazolopyridine-analog compounds of Formula I:




or pharmaceutically acceptable salts or esters thereof, which target the nucleotide-binding oligomerization domain, leucine rich repeat containing X1 (NLRX1) protein are described. Also described are methods of using the compounds in the treatment of chronic and/or inflammatory respiratory diseases, chronic and/or inflammatory diseases of the central nervous system, allergic diseases, autoimmune diseases, cardiovascular diseases, diabetes, hypereosinophilic syndrome, granulomatous disorders, cancer, and/or infectious diseases, among others. Exemplary conditions include asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, Alzheimer's disease, atopic dermatitis, eosinophilic gastroenteritis, eosinophilic esophagitis, diabetes, and granulomatous disorders such as Churg-Strauss syndrome, berylliosis, and sarcoidosis.

公开(公告)号：US20240269242A1

公开(公告)日：2024-08-15

申请号：US18586133

申请日：2024-02-23

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA ,  RAESEDO, LLC

发明人： Julie Ledford ,  Monica Kraft ,  Josef Vagner

IPC分类号： A61K38/17 ,  A61P11/06 ,  A61P31/14 ,  C07K14/785

CPC分类号： A61K38/395 ,  A61P11/06 ,  A61P31/14 ,  C07K14/785

摘要： Provided herein are compositions and methods for treating and preventing lung disease. In particular, provided herein are SP-A peptides and uses thereof in the treatment and prevention of lung disease (e.g., asthma or COPD). The compositions may comprise peptides having an amino acid sequence of Ac-WGKEQCVE(Nle)(Pego3)-Hdc (SEQ ID NO: 24) The peptide compositions may also be used to treat COVID-19.

公开(公告)号：US20240254215A1

公开(公告)日：2024-08-01

申请号：US18607180

申请日：2024-03-15

申请人： JIANGSU HENGRUI MEDICINE CO., LTD. ,  SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.

发明人： Jinping SHI ,  Hua YING ,  Tingting LI ,  Yifang WANG ,  Guimei YANG ,  Hu GE ,  Weikang TAO

IPC分类号： C07K16/24 ,  A61K39/00 ,  A61P11/06

CPC分类号： C07K16/24 ,  A61P11/06 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： Disclosed are an antibody capable of binding to thymic stromal lymphopoietin and the use thereof. Disclosed are an anti-TSLP antibody, comprising a murine antibody, chimeric antibody and humanized antibody of the light chain and heavy chain variable regions of the anti-TSLP antibody and antigen-binding fragments thereof, or a pharmaceutically acceptable salt or solvent compound thereof, and the use thereof as a medicament for treating asthma, especially the use thereof in the preparation of a drug for treating TSLP-positive diseases or conditions.

公开(公告)号：US20240216496A1

公开(公告)日：2024-07-04

申请号：US18330968

申请日：2023-06-07

申请人： Taichung Veterans General Hospital

发明人： Mey Fann LEE ,  Yi-Hsing CHEN

IPC分类号： A61K39/09 ,  A61K35/74 ,  A61P11/06 ,  A61P17/00 ,  A61P37/08 ,  C12N1/20 ,  C12N15/74

CPC分类号： A61K39/09 ,  A61K35/74 ,  A61P11/06 ,  A61P17/00 ,  A61P37/08 ,  C12N1/20 ,  C12N15/746 ,  C12N2800/101

摘要： A recombinant lactic acid bacterium and a method thereof for simultaneous treatment and/or prevention of dust mite and cockroach allergies. The recombinant lactic acid bacterium has a gene fragment with nucleotide coded as SEQ ID No: 1 to be capable of expressing the D2P2 protein with amino acid sequence of SEQ ID No: 2. Therefore, by administering an effective amount of the recombinant lactic acid bacterium to an individual is capable of effectively causing the individual's body to produce antibodies against dust mite and/or cockroach allergens, thereby achieving an efficacy of preventing and/or treating an allergic disease caused by dust mite and/or cockroach allergens.