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![7,8-dihydrobenzo[e]pyrido[3,4-c]azocine-2,5(3H,6H)-dione derivatives useful as a factor XIa inhibitors](/abs-image/US/2024/02/13/US11897880B2/abs.jpg.150x150.jpg)
公开(公告)号：US11897880B2
公开(公告)日：2024-02-13
申请号：US17732724
申请日：2022-04-29
发明人： Guozhang Xu , Tianbao Lu , Zhijie Liu , Micheal D. Gaul
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention is directed to 7,8-dihydrobenzo[e]pyrido[3,4-c]azocine-2,5(3H,6H)-dione derivatives, stereoisomers, isotopologues, isotopomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.
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公开(公告)号：US11814364B2
公开(公告)日：2023-11-14
申请号：US17696926
申请日：2022-03-17
发明人： Guozhang Xu , Boying Guo , Zhijie Liu , Jing Zhang , Micheal D. Gaul , Eugene B. Grant , Mark J. Macielag , Tianbao Lu , Tho V. Thieu
IPC分类号： C07D401/14 , C07D417/14 , C07D413/14 , C07D405/14
CPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to pyridine N-oxide derivatives, stereoisomers, isotopologues, isotopomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.
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公开(公告)号：US20180065955A1
公开(公告)日：2018-03-08
申请号：US15695118
申请日：2017-09-05
发明人： Micheal Gaul , Guozhang Xu , Shyh-Ming Yang , Tianbao Lu , Rui Zhang , Fengbin Song
IPC分类号： C07D405/14 , C07D231/56 , C07D401/06 , C07D405/04 , C07D409/04 , C07D403/04
CPC分类号： C07D405/14 , C07D231/56 , C07D401/04 , C07D401/06 , C07D403/04 , C07D405/04 , C07D409/04
摘要： The present invention is directed to indazole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
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公开(公告)号：US20180065934A1
公开(公告)日：2018-03-08
申请号：US15695129
申请日：2017-09-05
发明人： Micheal Gaul , Guozhang Xu , Shyh-Ming Yang , Tianbao Lu , Rui Zhang , Fengbin Song
IPC分类号： C07D231/56 , C07D401/06 , C07D405/14 , C07D405/04 , C07D409/04
CPC分类号： C07D231/56 , A61K31/416 , C07D401/06 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04
摘要： The present invention is directed to indazole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
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5.发明授权Benzamide derivative useful as FASN inhibitors for the treatment of cancer 有权苯甲酰胺衍生物可用作治疗癌症的FASN抑制剂公开(公告)号：US09562035B2
公开(公告)日：2017-02-07
申请号：US14550349
申请日：2014-11-21
发明人： Peter J Connolly , Tianbao Lu
IPC分类号： C07D401/14 , C07D487/04 , C07D417/14 , C07D413/14 , C07D401/10 , C07D409/14 , C07D405/14 , A61K31/5377 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/4709 , C07D401/12 , C07D403/10 , C07D471/04 , A61K31/437 , A61K31/454 , A61K31/4545
CPC分类号： C07D401/14 , A61K31/437 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , C07D401/10 , C07D401/12 , C07D403/10 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention is directed to benzamide derivatives, pharmaceutical compositions containing them, and their use as FASN inhibitors, in for example, the treatment of cancer, obesity related disorders, liver related disorders and viral infections. Such compounds are represented by formula (I) as follows: wherein R1, R2, R3, R4, R5, m, n, are defined herein.
摘要翻译： 本发明涉及苯甲酰胺衍生物，含有它们的药物组合物及其作为FASN抑制剂的用途，例如治疗癌症，肥胖相关疾病，肝脏相关病症和病毒感染。 这样的化合物由式（I）表示如下：其中R 1，R 2，R 3，R 4，R 5，m，n在本文中定义。
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公开(公告)号：US10888550B2
公开(公告)日：2021-01-12
申请号：US16440356
申请日：2019-06-13
发明人： Tianbao Lu , Peter J. Connolly , Maxwell David Cummings , Gaston Stanislas Marcella Diels , Jan Willem Thuring , Ulrike Philippar , James Patrick Edwards , Didier Jean-Claude Berthelot , Tongfei Wu
IPC分类号： A61K31/437 , A61P35/00 , A61K31/519 , C07D471/04 , C07K16/28
摘要： Disclosed are compounds, compositions and methods for treating of diseases, syndromes, conditions, and disorders that are affected by the modulation of MALT1. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, R5, R6, R7, G1 and G2, are defined herein.
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公开(公告)号：US20140364414A1
公开(公告)日：2014-12-11
申请号：US14299512
申请日：2014-06-09
发明人： Mark R. Player , Sanath K. Meegalla , Carl R. Illig , Jinsheng Chen , Kenneth J. Wilson , Yu-Kai Lee , Daniel J. Parks , Hui Huang , Sharmila Patel , Tianbao Lu
IPC分类号： C07D519/00 , C07D487/04
CPC分类号： C07D519/00 , C07D487/04
摘要： Disclosed are compounds, compositions and methods for treating Type II diabetes. Such compounds are represented by Formula (I) as follows: wherein R1, R2, L, and Q are defined herein.
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公开(公告)号：US11040031B2
公开(公告)日：2021-06-22
申请号：US16440302
申请日：2019-06-13
发明人： Tianbao Lu , Peter J. Connolly , Maxwell David Cummings , Joseph Kent Barbay , Kevin D. Kreutter , Tongfei Wu , Gaston Stanislas Marcella Diels , Jan Willem Thuring , Ulrike Philippar , James Patrick Edwards , Fang Shen
IPC分类号： A61K31/444 , A61P35/00 , A61K31/519 , A61K31/5377 , A61K39/395 , C07D403/14 , C07D407/14 , C07D413/14
摘要： Disclosed are compounds, compositions and methods for treating of diseases, syndromes, conditions, and disorders that are affected by the modulation of MALT1. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, R5, and G, are defined herein.
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公开(公告)号：US10774048B2
公开(公告)日：2020-09-15
申请号：US16242902
申请日：2019-01-08
发明人： Guozhang Xu , Micheal Gaul , Shyh-Ming Yang , Tianbao Lu , Rui Zhang , Fengbin Song
IPC分类号： A61K31/416 , C07D231/56 , C07D401/06 , C07D405/14 , C07D405/04 , C07D409/04 , C07D403/04
摘要： The present invention is directed to indazole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
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公开(公告)号：US10000473B2
公开(公告)日：2018-06-19
申请号：US15695118
申请日：2017-09-05
发明人： Micheal Gaul , Guozhang Xu , Shyh-Ming Yang , Tianbao Lu , Rui Zhang , Fengbin Song
IPC分类号： C07D405/14 , C07D409/04 , C07D405/04 , C07D403/04 , C07D231/56 , C07D401/06
CPC分类号： C07D405/14 , C07D231/56 , C07D401/04 , C07D401/06 , C07D403/04 , C07D405/04 , C07D409/04
摘要： The present invention is directed to indazole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
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