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公开(公告)号：US11732019B2
公开(公告)日：2023-08-22
申请号：US17168325
申请日：2021-02-05
发明人： Mark Macielag , Raymond J. Patch , Rui Zhang , Martin A. Case , Mark J. Wall , Yue-Mei Zhang
IPC分类号： C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00 , A61K38/00 , A61K39/00
CPC分类号： C07K14/575 , A61K9/0019 , A61K38/17 , A61K38/1709 , A61K38/22 , A61K38/26 , A61K45/06 , A61K47/60 , A61K47/64 , A61K47/68 , A61K47/6811 , A61K47/6845 , A61K47/6883 , A61K49/0032 , A61K49/0052 , A61K49/0056 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , C07K1/061 , C07K1/1072 , C07K1/12 , C07K1/18 , C07K5/0205 , C07K14/57545 , C07K16/00 , C07K16/24 , A61K38/00 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/92 , C07K2317/94 , C07K2319/30
摘要： The present invention comprises compounds of Formula I.
wherein:
Z4, Z7, Z9, Z11, Z22, Z23, Z26, Z30, Z34, Z35, p, m, n, q, and BRIDGE are defined in the specification. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel compounds are useful for preventing, treating or ameliorating diseases and disorders, such as obesity, type 2 diabetes, the metabolic syndrome, insulin resistance, and dyslipidemia, among others.-
公开(公告)号：US20180065955A1
公开(公告)日：2018-03-08
申请号：US15695118
申请日：2017-09-05
发明人： Micheal Gaul , Guozhang Xu , Shyh-Ming Yang , Tianbao Lu , Rui Zhang , Fengbin Song
IPC分类号： C07D405/14 , C07D231/56 , C07D401/06 , C07D405/04 , C07D409/04 , C07D403/04
CPC分类号： C07D405/14 , C07D231/56 , C07D401/04 , C07D401/06 , C07D403/04 , C07D405/04 , C07D409/04
摘要： The present invention is directed to indazole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
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公开(公告)号：US20180065934A1
公开(公告)日：2018-03-08
申请号：US15695129
申请日：2017-09-05
发明人： Micheal Gaul , Guozhang Xu , Shyh-Ming Yang , Tianbao Lu , Rui Zhang , Fengbin Song
IPC分类号： C07D231/56 , C07D401/06 , C07D405/14 , C07D405/04 , C07D409/04
CPC分类号： C07D231/56 , A61K31/416 , C07D401/06 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04
摘要： The present invention is directed to indazole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
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公开(公告)号：US11591379B2
公开(公告)日：2023-02-28
申请号：US16820174
申请日：2020-03-16
发明人： Mark Macielag , Raymond J. Patch , Rui Zhang , Martin A. Case , Shamina M. Rangwala , James N. Leonard , Raul C. Camacho , Michael J. Hunter , Katharine E. D'Aquino , Wilson Edwards , Ronald V. Swanson , Wenying Jian , Yue-Mei Zhang , Mark J. Wall , Ellen Chi
IPC分类号： C07K14/575 , A61K47/68 , C07K16/24 , A61K38/17 , A61K38/26 , A61K47/64 , A61P3/10 , A61K47/60 , A61P3/08 , A61P3/04 , A61P3/06 , A61K38/22 , A61K9/00 , C07K1/06 , C07K1/107 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61P3/00 , A61K45/06 , C07K16/00 , A61K38/00 , A61K39/00
摘要： The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.
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公开(公告)号：US10968264B2
公开(公告)日：2021-04-06
申请号：US15794231
申请日：2017-10-26
发明人： Mark Macielag , Raymond J Patch , Rui Zhang , Martin A Case , Yue-Mei Zhang , Mark Wall
IPC分类号： C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00 , A61K38/00 , A61K39/00
摘要： The present invention comprises compounds of Formula I. wherein: Z4, Z7, Z9, Z11, Z22, Z23, Z26, Z30, Z34, Z35, p, m, n, q, and BRIDGE are defined in the specification. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel compounds are useful for preventing, treating or ameliorating diseases and disorders, such as obesity, type 2 diabetes, the metabolic syndrome, insulin resistance, and dyslipidemia, among others.
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公开(公告)号：US10774048B2
公开(公告)日：2020-09-15
申请号：US16242902
申请日：2019-01-08
发明人： Guozhang Xu , Micheal Gaul , Shyh-Ming Yang , Tianbao Lu , Rui Zhang , Fengbin Song
IPC分类号： A61K31/416 , C07D231/56 , C07D401/06 , C07D405/14 , C07D405/04 , C07D409/04 , C07D403/04
摘要： The present invention is directed to indazole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
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公开(公告)号：US20190192475A1
公开(公告)日：2019-06-27
申请号：US16292406
申请日：2019-03-05
发明人： Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan R. DeAngelis
IPC分类号： A61K31/277 , C07C323/20 , C07D333/28 , C07D333/16 , C07C323/62 , A61K31/192 , C07C317/22 , C07C59/70 , C07C59/68 , C07C323/60
CPC分类号： A61K31/277 , A61K31/192 , C07C59/68 , C07C59/70 , C07C317/22 , C07C323/20 , C07C323/60 , C07C323/62 , C07D333/16 , C07D333/28
摘要： The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.
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公开(公告)号：US10000473B2
公开(公告)日：2018-06-19
申请号：US15695118
申请日：2017-09-05
发明人： Micheal Gaul , Guozhang Xu , Shyh-Ming Yang , Tianbao Lu , Rui Zhang , Fengbin Song
IPC分类号： C07D405/14 , C07D409/04 , C07D405/04 , C07D403/04 , C07D231/56 , C07D401/06
CPC分类号： C07D405/14 , C07D231/56 , C07D401/04 , C07D401/06 , C07D403/04 , C07D405/04 , C07D409/04
摘要： The present invention is directed to indazole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
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公开(公告)号：US20180127476A1
公开(公告)日：2018-05-10
申请号：US15794231
申请日：2017-10-26
发明人： Mark Macielag , Raymond J. Patch , Rui Zhang , Martin A. Case , Yue-Mei Zhang , Mark Wall
摘要： The present invention comprises compounds of Formula I. wherein: Z4, Z7, Z9, Z11, Z22, Z23, Z26, Z30, Z34, Z35, p, m, n, q, and BRIDGE are defined in the specification. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel compounds are useful for preventing, treating or ameliorating diseases and disorders, such as obesity, type 2 diabetes, the metabolic syndrome, insulin resistance, and dyslipidemia, among others.
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10.发明申请公开(公告)号：US20180117170A1
公开(公告)日：2018-05-03
申请号：US15794171
申请日：2017-10-26
发明人： Mark Macielag , Raymond J Patch , Rui Zhang , Martin A Case , Shamina M Rangwala , James N Leonard , Raul C Camacho , Michael J Hunter , Katharine E. D'Aquino , Wilson Edwards , Ronald V Swanson , Wenying Jian , Yue-Mei Zhang , Mark Wall , Ellen Chi
摘要： The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.
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