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公开(公告)号:US20190177322A1
公开(公告)日:2019-06-13
申请号:US16275045
申请日:2019-02-13
发明人: Kevin D. Kreutter , Kristi Leonard , Michele C. Rizzolio , Russell C. Smith , Mark S. Tichenor , Aihua Wang
IPC分类号: C07D471/14
摘要: 2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions mediated by JAK, such as inflammatory bowel disease.
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公开(公告)号:US20160136149A1
公开(公告)日:2016-05-19
申请号:US15004048
申请日:2016-01-22
发明人: Kristi A. Leonard , Kent Barbay , James P. Edwards , Kevin D. Kreutter , David A. Kummer , Umar Maharoof , Rachel Nishimura , Maud Urbanski , Hariharan Venkatesan , Aihua Wang , Ronald L. Wolin , Craig R. Woods , Anne Fourie , Xiaohua Xue , Maxwell D. Cummings
IPC分类号: A61K31/4709 , A61K45/06
CPC分类号: A61K31/4709 , A61K45/06 , C07D401/12 , C07D401/14 , A61K2300/00
摘要: The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7 R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.
摘要翻译: 本发明包括式I化合物,其中:R1,R2,R3,R4,R5,R6,R7R8和R9如说明书所定义。 本发明还包括治疗或改善综合征,病症或疾病的方法,其中所述综合征,病症或疾病是类风湿性关节炎或牛皮癣。 本发明还包括通过施用治疗有效量的至少一种权利要求1的化合物来调节哺乳动物的RORγt活性的方法。
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公开(公告)号:US09309222B2
公开(公告)日:2016-04-12
申请号:US14053707
申请日:2013-10-15
发明人: Kristi A. Leonard , Kent Barbay , James P. Edwards , Kevin D. Kreutter , David A. Kummer , Umar Maharoof , Rachel Nishimura , Maud Urbanski , Hariharan Venkatesan , Aihua Wang , Ronald L. Wolin , Craig R. Woods , Anne Fourie , Xiaohua Xue , Taraneh Mirzadegan , Kelly Ganamet
IPC分类号: C07D401/06 , C07D401/14 , A61K31/4709 , A61K45/06 , A61K31/501 , A61K31/497 , A61K31/506 , C07D413/14 , C07D413/06 , C07D417/14 , C07D409/14
CPC分类号: C07D401/06 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07D401/14 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/14
摘要: The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.
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公开(公告)号:US20210340143A1
公开(公告)日:2021-11-04
申请号:US17355472
申请日:2021-06-23
发明人: Tatiana Koudriakova , Kevin D. Kreutter , Kristi Leonard , Michele C. Rizzolio , Russell C. Smith , Mark S. Tichenor , Aihua Wang
IPC分类号: C07D471/14
摘要: 2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions mediated by JAK, such as inflammatory bowel disease.
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公开(公告)号:US20190322665A1
公开(公告)日:2019-10-24
申请号:US16469939
申请日:2017-12-15
发明人: Genesis M. Bacani , Wenying Chai , Tatiana Koudriakova , Paul J. Krawczuk , Kevin D. Kreutter , Kristi Leonard , Michele C. Rizzolio , Mark Seierstad , Russell C. Smith , Mark S. Tichenor , Jennifer D. Venable , Aihua Wang
IPC分类号: C07D471/14
摘要: 2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions mediated by JAK, such as inflammatory bowel disease.
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公开(公告)号:US10369146B2
公开(公告)日:2019-08-06
申请号:US15182231
申请日:2016-06-14
发明人: Kristi A. Leonard , Kent Barbay , James P. Edwards , Kevin D. Kreutter , David A. Kummer , Umar Maharoof , Rachel Nishimura , Maud Urbanski , Hariharan Venkatesan , Aihua Wang , Ronald L. Wolin , Craig R. Woods , Anne Fourie , Xiaohua Xue , Maxwell D. Cummings
IPC分类号: A61K31/4709 , A61K31/506 , A61K45/06 , C07D417/14 , C07D401/06 , C07D401/14 , C07D409/14
摘要: The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.
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公开(公告)号:US20190192475A1
公开(公告)日:2019-06-27
申请号:US16292406
申请日:2019-03-05
发明人: Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan R. DeAngelis
IPC分类号: A61K31/277 , C07C323/20 , C07D333/28 , C07D333/16 , C07C323/62 , A61K31/192 , C07C317/22 , C07C59/70 , C07C59/68 , C07C323/60
CPC分类号: A61K31/277 , A61K31/192 , C07C59/68 , C07C59/70 , C07C317/22 , C07C323/20 , C07C323/60 , C07C323/62 , C07D333/16 , C07D333/28
摘要: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.
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公开(公告)号:US20190185474A1
公开(公告)日:2019-06-20
申请号:US16243874
申请日:2019-01-09
发明人: Tatiana Koudriakova , Kevin D. Kreutter , Kristi Leonard , Michele C. Rizzolio , Russell C. Smith , Mark S. Tichenor , Aihua Wang
IPC分类号: C07D471/14
CPC分类号: C07D471/14
摘要: 2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions mediated by JAK, such as inflammatory bowel disease.
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公开(公告)号:US09845319B2
公开(公告)日:2017-12-19
申请号:US14927502
申请日:2015-10-30
发明人: Steven Goldberg , Hariharan Venkatesan , Virginia Tanis , Maud Urbanski , Aihua Wang , David Kummer , Christoph Steeneck , Christian Gege , Olaf Kinzel , Gerald Kleymann , Thomas Hoffmann , Anne M. Fourie , Xiaohua Xue
IPC分类号: C07D417/04 , C07D417/06 , C07D417/14 , A61K31/427 , A61K45/06 , A61K31/454 , A61K31/4439 , A61K31/4545
CPC分类号: C07D417/04 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K45/06 , C07D417/06 , C07D417/14
摘要: The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R5, A1, A2, and are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein the syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.
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公开(公告)号:US09724322B2
公开(公告)日:2017-08-08
申请号:US15074125
申请日:2016-03-18
发明人: Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan R. DeAngelis
IPC分类号: A61K31/277 , A61K31/192 , C07C323/20 , C07C59/68 , C07C59/70 , C07C317/22 , C07C323/60 , C07C323/62 , C07D333/16 , C07D333/28
CPC分类号: A61K31/277 , A61K31/192 , C07C59/68 , C07C59/70 , C07C317/22 , C07C323/20 , C07C323/60 , C07C323/62 , C07D333/16 , C07D333/28
摘要: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.
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