公开(公告)号：US11667606B2

公开(公告)日：2023-06-06

申请号：US16803853

申请日：2020-02-27

申请人： Autobahn Therapeutics, Inc.

发明人： Thomas von Geldern ,  Bradley Backes

IPC分类号： C07D205/04 ,  C07C59/68 ,  C07C69/734 ,  C07C235/34 ,  C07C235/38 ,  C07C317/46 ,  C07D203/16 ,  C07D207/08 ,  C07D213/55 ,  C07D239/26 ,  C07D307/54 ,  C07D333/24 ,  C07D333/28 ,  A61P5/14

CPC分类号： C07D205/04 ,  A61P5/14 ,  C07C59/68 ,  C07C69/734 ,  C07C235/34 ,  C07C235/38 ,  C07C317/46 ,  C07D203/16 ,  C07D207/08 ,  C07D213/55 ,  C07D239/26 ,  C07D307/54 ,  C07D333/24 ,  C07D333/28

摘要： Compounds are provided having the structure of Formula (I):




or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, X1, X2, Q, R1, R2 and n are as defined herein. Such compounds function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation.

公开(公告)号：US20220002478A1

公开(公告)日：2022-01-06

申请号：US17475914

申请日：2021-09-15

申请人： Rutgers, The State University of New Jersey

发明人： Joachim B. Kohn ,  Durgadas Bolikal

IPC分类号： C08G63/64 ,  A61L31/06 ,  A61L31/16 ,  C07C69/36 ,  C07C69/40 ,  C07C69/732 ,  C07C69/736 ,  C07C69/96 ,  A61K47/34 ,  C07C59/52 ,  C07C59/68 ,  C08G67/00 ,  A61L31/14 ,  A61L31/18 ,  C07C233/47 ,  C08G63/66

摘要： The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processability are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.

公开(公告)号：US11091420B2

公开(公告)日：2021-08-17

申请号：US16062562

申请日：2016-10-21

申请人： CJ Cheiljedang Corporation

发明人： Joo Hang Lee ,  Young Ho Hong ,  Ji Hyun Kang ,  Hwa Jeong Lee ,  Min Hoe Kim ,  Seung Won Park ,  Seong Jun Cho

IPC分类号： C07C59/68 ,  C07C51/47 ,  C07C59/64 ,  C07C59/13 ,  B01J20/20 ,  C07C51/42 ,  B01D17/00 ,  C07C51/48 ,  C07C51/43 ,  C12P7/42 ,  C08B30/04

摘要： The present disclosure relates to a series of preparation methods including extraction, separation, purification, and commercialization of ferulic acid, which is a highly functional material from corn brans (a by-product of grain), and more specifically, to a preparation method wherein ferulic acid is extracted from corn brans (a by-product of grain) in high yield by a novel method, and the extracted ferulic acid is separated and purified in high yield and high purity by an economical method, followed by commercialization.

公开(公告)号：US10202410B2

公开(公告)日：2019-02-12

申请号：US15282468

申请日：2016-09-30

申请人： Brigham Young University

发明人： Merritt B. Andrus ,  F. Brent Johnson ,  Mary Ruth Jaeger Greer ,  Rex G. Cates

IPC分类号： C07C59/68 ,  C07H15/207 ,  C07D307/88 ,  C07D307/92 ,  C07D317/48 ,  C07D407/12 ,  C07H15/203

摘要： The present disclosure relates to scaphopetalone analogs, methods of making the analogs, and their uses.

公开(公告)号：US20180369190A1

公开(公告)日：2018-12-27

申请号：US16063622

申请日：2016-12-22

申请人： MCMASTER UNIVERSITY

发明人： Sukhbinder Dhesy-Thind ,  Katarzyna J. Jerzak ,  Anita Bane ,  Jessica G. Cockburn ,  John A. Hassell

IPC分类号： A61K31/343 ,  A61P5/14 ,  A61K31/12 ,  C07C49/215 ,  A61K31/192 ,  C07C59/68 ,  C07D307/80 ,  A61K45/06

CPC分类号： A61K31/343 ,  A61K31/12 ,  A61K31/192 ,  A61K45/06 ,  A61P5/14 ,  A61P35/00 ,  C07C49/215 ,  C07C59/68 ,  C07D307/80

摘要： Two isoforms of thyroid receptor alpha (THRα1 and THRα2) have been found to be associated with the growth of cancer. Use of inhibitors of THRα1 (Formula I) and/or agonists of THRα2 (Formula II) in the treatment of such cancers is disclosed. Treatment of other disorders associated with such receptors is also contemplated, as is the use of diagnostic methods for predicting therapeutic outcomes based on the levels of expression of THRα1 and THRaα2 in a tissue sample.

公开(公告)号：US09416090B2

公开(公告)日：2016-08-16

申请号：US13757752

申请日：2013-02-02

申请人： Rutgers, The State University of New Jersey

发明人： Joachim B. Kohn ,  Durgadas Bolikal

IPC分类号： C08G63/02 ,  C08G63/06 ,  A61K47/30 ,  C07C59/52 ,  A61K47/34 ,  C07C59/68 ,  C08G67/00 ,  C07C69/36 ,  C07C69/40 ,  C07C69/732 ,  C07C69/736 ,  C07C69/96 ,  C08G63/64 ,  A61L31/06 ,  A61L31/16

CPC分类号： C08G63/64 ,  A61K47/34 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/416 ,  C07C59/52 ,  C07C59/68 ,  C07C69/36 ,  C07C69/40 ,  C07C69/732 ,  C07C69/736 ,  C07C69/96 ,  C07C233/47 ,  C08G63/66 ,  C08G67/00 ,  C08G2230/00

摘要： The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogs, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.

摘要翻译： 本发明提供新类型的酚化合物，包括衍生自酪醇和类似物的那些，其可用作制备生物相容性聚合物的单体，以及由这些单体酚化合物制备的生物相容性聚合物，包括新的可生物降解和/或生物可再吸收的聚合物。 具有增强的生物可再生性和加工性的这些生物相容性聚合物或聚合物组合物可用于各种医疗应用，例如在医疗装置和控制释放治疗制剂中。 本发明还提供了制备这些单体酚化合物和生物相容性聚合物的方法。

公开(公告)号：US09249084B2

公开(公告)日：2016-02-02

申请号：US13982733

申请日：2012-01-31

申请人： Qiang Zhang ,  Rongxia Zhang ,  Guanghui Tian ,  Jianfeng Li ,  Fuqiang Zhu ,  Xiangrui Jiang ,  Jingshan Shen

发明人： Qiang Zhang ,  Rongxia Zhang ,  Guanghui Tian ,  Jianfeng Li ,  Fuqiang Zhu ,  Xiangrui Jiang ,  Jingshan Shen

IPC分类号： C07C213/02 ,  C07C59/64 ,  C07C235/34 ,  C07C309/75 ,  C07C309/66 ,  C07C43/225 ,  C07D263/26 ,  C07C17/16 ,  C07C215/54 ,  C07C217/62 ,  C07C309/73 ,  C07D263/52 ,  C07C43/23 ,  C07C59/68 ,  C07C41/26

CPC分类号： C07C235/34 ,  C07C17/16 ,  C07C41/26 ,  C07C43/225 ,  C07C43/23 ,  C07C59/64 ,  C07C59/68 ,  C07C213/02 ,  C07C215/54 ,  C07C217/62 ,  C07C309/66 ,  C07C309/73 ,  C07C309/75 ,  C07D263/26 ,  C07D263/52 ,  Y02P20/582 ,  C07C22/04

摘要： The present invention relates to a (2R,3R)-3-(3-substituted phenyl)-2-methyl n-pentanamide compounds as shown in the formula I and the preparation method thereof, wherein, the substituents are as defined in the specification, the present invention further relates to a use of the above compounds for the preparation of tapentadol II or its pharmaceutically acceptable salt, and the intermediates involved in the preparation process.

摘要翻译： 本发明涉及式I所示的（2R，3R）-3-（3-取代苯基）-2-甲基正戊酰胺化合物及其制备方法，其中取代基如本说明书中所定义 ，本发明还涉及上述化合物在制备他喷他多II或其药学上可接受的盐中的用途，以及参与制备方法的中间体。

公开(公告)号：US20130030059A1

公开(公告)日：2013-01-31

申请号：US13417660

申请日：2012-03-12

申请人： Xiaodong Li ,  Lena Staszewski ,  Hong Xu

发明人： Xiaodong Li ,  Lena Staszewski ,  Hong Xu

IPC分类号： C07C59/68 ,  C07K5/075 ,  C07C307/02 ,  A23L1/236 ,  A61K47/18 ,  A61K47/12 ,  A61K47/20 ,  A23L1/22 ,  C07D307/81 ,  A61K47/22

CPC分类号： G01N33/543 ,  A23L2/56 ,  A23L27/202 ,  A23L27/203 ,  A23L27/2054 ,  A23L27/88 ,  A23V2002/00 ,  A61K8/4973 ,  A61K8/55 ,  A61K47/22 ,  A61K47/24 ,  C07C233/65 ,  C07C235/54 ,  C07C275/30 ,  C07C275/34 ,  C07D307/84 ,  C07D317/68 ,  C07D405/12 ,  C07F9/65517 ,  G01N33/5041 ,  G01N33/566 ,  G01N33/74 ,  G01N2333/726

摘要： The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or sub-units thereof. The present invention also relates to the use of hetero-oligomeric and chimeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T11 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging.

摘要翻译： 本发明涉及特异性结合T1R1 / T1R3或T1R2 / T1R3受体或其片段或亚单位的化合物。 本发明还涉及包含T1R1 / T1R3和T1R2 / T1R3的异低聚和嵌合味觉感受器在测定中用于鉴定分别响应于鲜味刺激和甜味刺激的化合物的用途。 此外，本发明涉及稳定或瞬时共表达T11和T1R3的组合的细胞系的组成; 或T1R2和T1R3; 在组成型或诱导性条件下。 还提供了在基于细胞的测定中使用这些细胞系以鉴定鲜味和甜味调节化合物，特别是通过使用荧光成像检测受体活性的高通量筛选测定。

公开(公告)号：US20120264603A1

公开(公告)日：2012-10-18

申请号：US13267970

申请日：2011-10-07

申请人： David S. Soane ,  Gangadhar Jogikalmath

发明人： David S. Soane ,  Gangadhar Jogikalmath

IPC分类号： C08G63/91 ,  A01N39/04 ,  A01N37/10 ,  A01N43/40 ,  A01N37/22 ,  A01N47/24 ,  A01N35/10 ,  A01N25/10 ,  A01N25/34 ,  A01N43/707 ,  A01N43/50 ,  A01N47/34 ,  A01N43/78 ,  C07C59/70 ,  C07C59/68 ,  C07C65/21 ,  C07D213/83 ,  C07C233/18 ,  C07C311/53 ,  C07C251/52 ,  A01N25/26 ,  A01P13/00 ,  A01P7/04 ,  A01P3/00 ,  C08G65/48 ,  A01N39/02

CPC分类号： A01N25/10 ,  A01N25/26 ,  A01N35/10 ,  A01N37/22 ,  A01N37/40 ,  A01N37/46 ,  A01N39/04 ,  A01N43/40 ,  A01N43/653 ,  A01N43/707 ,  A01N47/24 ,  A01N37/26 ,  A01N43/50 ,  A01N43/70 ,  A01N43/78 ,  A01N43/88 ,  A01N47/36

摘要： The invention encompasses formulations for increased attachment and retention systems of biologically active organic compounds and methods for the preparation and use thereof.

摘要翻译： 本发明包括用于增加生物活性有机化合物的附着和保留系统的制剂及其制备和使用方法。

公开(公告)号：US20120258911A1

公开(公告)日：2012-10-11

申请号：US13474491

申请日：2012-05-17

申请人： David Gschneidner ,  Stephen V. Pusztay

发明人： David Gschneidner ,  Stephen V. Pusztay

IPC分类号： A61K47/12 ,  A61K38/02 ,  A61K31/715 ,  A61K31/70 ,  A61K38/28 ,  C07C59/64 ,  C07C57/58 ,  C07C57/30 ,  C07C59/68 ,  A61P31/12 ,  A61P3/10 ,  A61P35/00 ,  A61P19/10 ,  A61P7/06 ,  A61P9/08 ,  A61P31/18 ,  A61K38/16

CPC分类号： A61K47/12 ,  A61K9/0095 ,  A61K9/2013 ,  A61K38/26 ,  A61K38/28 ,  A61K45/06

摘要： The present invention provides phenylalkylcarboxylic acid compounds and compositions containing such compounds which facilitate the delivery of biologically active agents.

摘要翻译： 本发明提供苯基烷基羧酸化合物和含有这些化合物的组合物，其有助于递送生物活性剂。