公开(公告)号：US20240254075A1

公开(公告)日：2024-08-01

申请号：US18558726

申请日：2022-05-06

Applicant: Autobahn Therapeutics, Inc.

Inventor： Brian Andrew STEARNS ,  Jill Melissa BACCEI ,  Jason Randall HARRIS

IPC: C07C235/20 ,  A61K31/16 ,  A61K31/165 ,  A61K31/397 ,  A61K31/40 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/455 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/505 ,  A61K31/5375 ,  A61P25/00 ,  C07C235/16 ,  C07C235/22 ,  C07C235/24 ,  C07C243/28 ,  C07C255/29 ,  C07C259/06 ,  C07C313/02 ,  C07C317/28 ,  C07D205/04 ,  C07D213/75 ,  C07D237/20 ,  C07D237/22 ,  C07D239/42 ,  C07D241/20 ,  C07D261/14 ,  C07D295/18 ,  C07D305/08

CPC classification number: C07C235/20 ,  A61K31/16 ,  A61K31/165 ,  A61K31/397 ,  A61K31/40 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/455 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/505 ,  A61K31/5375 ,  A61P25/00 ,  C07C235/16 ,  C07C235/22 ,  C07C235/24 ,  C07C243/28 ,  C07C255/29 ,  C07C259/06 ,  C07C313/02 ,  C07C317/28 ,  C07D205/04 ,  C07D213/75 ,  C07D237/20 ,  C07D237/22 ,  C07D239/42 ,  C07D241/20 ,  C07D261/14 ,  C07D295/18 ,  C07D305/08 ,  C07C2601/02 ,  C07C2601/14

Abstract: Provided herein are fatty acid amide (FAAH) cleavable prodrugs of thyromimetics and pharmaceutical compositions comprising these compounds with at least one pharmaceutically acceptable excipient further comprising a peripherally restricted FAAH inhibitor.

公开(公告)号：US20230242492A1

公开(公告)日：2023-08-03

申请号：US18002035

申请日：2021-06-17

Applicant: Autobahn Therapeutics, Inc.

Inventor： Thomas von GELDERN ,  Bradley BACKES

IPC: C07D253/075 ,  C07C39/367 ,  C07D261/12

CPC classification number: C07D253/075 ,  C07C39/367 ,  C07D261/12

Abstract: Disclosed herein are thyromimetic compounds having utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their preparation.

公开(公告)号：US20210053917A1

公开(公告)日：2021-02-25

申请号：US16803853

申请日：2020-02-27

Applicant: Autobahn Therapeutics, Inc.

Inventor： Thomas von Geldern ,  Bradley Backes

IPC: C07D205/04 ,  C07C59/68 ,  C07C69/734 ,  C07C235/34 ,  C07C235/38 ,  C07C317/46 ,  C07D333/24 ,  C07D333/28 ,  C07D307/54 ,  C07D213/55 ,  C07D239/26 ,  C07D203/16 ,  C07D207/08

Abstract: Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, X1, X2, Q, R1, R2 and n are as defined herein. Such compounds function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation.

公开(公告)号：US20240261414A1

公开(公告)日：2024-08-08

申请号：US18558709

申请日：2022-05-06

Applicant: Autobahn Therapeutics, Inc.

Inventor： Brian Andrew STEARNS ,  Jill Melissa BACCEI ,  Jason Randall HARRIS

IPC: A61K47/54 ,  A61K31/4545

CPC classification number: A61K47/542 ,  A61K31/4545 ,  A61K47/545

Abstract: Provided herein are fatty acid amide (FAAH) cleavable prodrugs of compounds that modulate a target in the brain including sphingosine-1-phosphate receptor (S1P1), lysophosphatidic acid receptor 1 (LPA1), G-protein coupled receptor 120 (GPR120), prostacyclin (PGI2), and transthyretin (TTR). Pharmaceutical compositions comprising these prodrugs, including in combination with a peripherally restricted FAAH inhibitor, and at least one pharmaceutically acceptable excipient, are also provided, and the use of these compounds and compositions in the treatment of CNS diseases or disorders.

公开(公告)号：US20230242471A1

公开(公告)日：2023-08-03

申请号：US18002037

申请日：2021-06-17

Applicant: Autobahn Therapeutics, Inc.

Inventor： Thomas von GELDERN ,  Bradley BACKES ,  Brian Andrew STEARNS ,  Jill Melissa BACCEI ,  Jason Randall HARRIS

IPC: C07C59/56 ,  C07C229/20 ,  C07C237/20 ,  C07C317/46

CPC classification number: C07C59/56 ,  C07C229/20 ,  C07C237/20 ,  C07C317/46

Abstract: Compounds provided herein function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their preparation.

公开(公告)号：US11827596B2

公开(公告)日：2023-11-28

申请号：US16712815

申请日：2019-12-12

Applicant: Autobahn Therapeutics, Inc.

Inventor： Thomas von Geldern ,  Jean-Christophe Poupon ,  Bradley Backes

IPC: C07C69/157 ,  A61P5/14 ,  C07C233/11 ,  C07C57/36

CPC classification number: C07C69/157 ,  A61P5/14 ,  C07C57/36 ,  C07C233/11

Abstract: Compounds are provided having the structure of Formula (I):




or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X1, X2, and R1 are as defined herein. Such compounds function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation.

公开(公告)号：US11667606B2

公开(公告)日：2023-06-06

申请号：US16803853

申请日：2020-02-27

Applicant: Autobahn Therapeutics, Inc.

Inventor： Thomas von Geldern ,  Bradley Backes

IPC: C07D205/04 ,  C07C59/68 ,  C07C69/734 ,  C07C235/34 ,  C07C235/38 ,  C07C317/46 ,  C07D203/16 ,  C07D207/08 ,  C07D213/55 ,  C07D239/26 ,  C07D307/54 ,  C07D333/24 ,  C07D333/28 ,  A61P5/14

CPC classification number: C07D205/04 ,  A61P5/14 ,  C07C59/68 ,  C07C69/734 ,  C07C235/34 ,  C07C235/38 ,  C07C317/46 ,  C07D203/16 ,  C07D207/08 ,  C07D213/55 ,  C07D239/26 ,  C07D307/54 ,  C07D333/24 ,  C07D333/28

Abstract: Compounds are provided having the structure of Formula (I):




or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, X1, X2, Q, R1, R2 and n are as defined herein. Such compounds function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation.

公开(公告)号：US20230348364A1

公开(公告)日：2023-11-02

申请号：US18000508

申请日：2021-06-03

Applicant: Autobahn Therapeutics, Inc.

Inventor： Bradley BACKES ,  Thomas von GELDERN

IPC: A61P25/28 ,  C07C235/20 ,  C07C69/712

CPC classification number: C07C235/20 ,  A61P25/28 ,  C07C69/712

Abstract: Isotopic compounds are provided that function as thyromimetics, which compounds have utility for treating diseases such as neurodegenerative disorders. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation.

公开(公告)号：US20230242473A1

公开(公告)日：2023-08-03

申请号：US18002036

申请日：2021-06-17

Applicant: Autobahn Therapeutics, Inc.

Inventor： Thomas von GELDERN ,  Bradley BACKES

IPC: C07C69/618 ,  C07C59/72 ,  C07C235/20 ,  C07C59/70

CPC classification number: C07C69/618 ,  C07C59/72 ,  C07C235/20 ,  C07C59/70 ,  C07C2602/08

Abstract: Compounds are provided herein function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their preparation.

公开(公告)号：US20230048992A1

公开(公告)日：2023-02-16

申请号：US17780465

申请日：2020-11-25

Applicant: Autobahn Therapeutics, Inc.

Inventor： Thomas von GELDERN ,  Bradley BACKES ,  Baoku HE ,  Jason HARRIS

IPC: C07C69/734 ,  C07C59/70 ,  C07C235/74 ,  C07C259/06 ,  C07C243/18 ,  C07D205/04 ,  C07D261/14 ,  A61P11/00

Abstract: Compounds are provided having the structure of Formula (I) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R1, R2, X1, X2, Y1, and Y2 are as defined herein. Such compounds function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation.