公开(公告)号：US20240254075A1

公开(公告)日：2024-08-01

申请号：US18558726

申请日：2022-05-06

Applicant: Autobahn Therapeutics, Inc.

Inventor： Brian Andrew STEARNS ,  Jill Melissa BACCEI ,  Jason Randall HARRIS

IPC: C07C235/20 ,  A61K31/16 ,  A61K31/165 ,  A61K31/397 ,  A61K31/40 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/455 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/505 ,  A61K31/5375 ,  A61P25/00 ,  C07C235/16 ,  C07C235/22 ,  C07C235/24 ,  C07C243/28 ,  C07C255/29 ,  C07C259/06 ,  C07C313/02 ,  C07C317/28 ,  C07D205/04 ,  C07D213/75 ,  C07D237/20 ,  C07D237/22 ,  C07D239/42 ,  C07D241/20 ,  C07D261/14 ,  C07D295/18 ,  C07D305/08

CPC classification number: C07C235/20 ,  A61K31/16 ,  A61K31/165 ,  A61K31/397 ,  A61K31/40 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/455 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/505 ,  A61K31/5375 ,  A61P25/00 ,  C07C235/16 ,  C07C235/22 ,  C07C235/24 ,  C07C243/28 ,  C07C255/29 ,  C07C259/06 ,  C07C313/02 ,  C07C317/28 ,  C07D205/04 ,  C07D213/75 ,  C07D237/20 ,  C07D237/22 ,  C07D239/42 ,  C07D241/20 ,  C07D261/14 ,  C07D295/18 ,  C07D305/08 ,  C07C2601/02 ,  C07C2601/14

Abstract: Provided herein are fatty acid amide (FAAH) cleavable prodrugs of thyromimetics and pharmaceutical compositions comprising these compounds with at least one pharmaceutically acceptable excipient further comprising a peripherally restricted FAAH inhibitor.

公开(公告)号：US09801867B2

公开(公告)日：2017-10-31

申请号：US15175824

申请日：2016-06-07

Applicant: AMGEN INC.

Inventor： Matthew Bio ,  Sebastien Caille ,  Brian Cochran ,  Yuanqing Fang ,  Brian M. Fox ,  Brian S. Lucas ,  Lawrence R. McGee ,  Filisaty Vounatsos ,  Sean H. Wiedemann ,  Sarah Wortman

IPC: C07D211/76 ,  A61K31/451 ,  C07D211/94 ,  C07D491/048 ,  C07C309/25 ,  C07C309/04 ,  C07C313/02 ,  C07D498/04 ,  C07C309/35

CPC classification number: A61K31/451 ,  C07B2200/13 ,  C07C309/04 ,  C07C309/25 ,  C07C309/35 ,  C07C313/02 ,  C07D211/76 ,  C07D211/94 ,  C07D491/048 ,  C07D498/04

Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.

公开(公告)号：US09623018B2

公开(公告)日：2017-04-18

申请号：US15175805

申请日：2016-06-07

Applicant: AMGEN INC.

Inventor： Matthew Bio ,  Sebastien Caille ,  Yuanqing Fang ,  Brian M. Fox ,  Brian S. Lucas ,  Lawrence R. McGee ,  Sean H. Wiedemann

IPC: C07D498/04 ,  A61K31/451 ,  C07D211/94 ,  C07D491/048 ,  C07C309/25 ,  C07C309/04 ,  C07D211/76 ,  C07C309/35

CPC classification number: A61K31/451 ,  C07B2200/13 ,  C07C309/04 ,  C07C309/25 ,  C07C309/35 ,  C07C313/02 ,  C07D211/76 ,  C07D211/94 ,  C07D491/048 ,  C07D498/04

Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.

公开(公告)号：US20070249749A1

公开(公告)日：2007-10-25

申请号：US11380028

申请日：2006-04-25

Applicant: Rajdeep Kalgutkar ,  Michael Palazzotto

Inventor： Rajdeep Kalgutkar ,  Michael Palazzotto

IPC: C08F2/50

CPC classification number: A61K6/083 ,  A61K6/0017 ,  A61K6/0023 ,  A61K6/0052 ,  B33Y70/00 ,  C07C313/02 ,  C08F2/50 ,  G03F7/029 ,  C08L33/04

Abstract: Compositions are provided that include an electron donor and a sensitizing compound. More specifically, the electron donor is an arylsulfinate salt. Methods of polymerization are also provided that can be used to prepare polymeric material from a photopolymerizable composition that includes ethylenically unsaturated monomers and a photoinitiator system. The photoinitiator system includes an electron donor and a sensitizing compound.

Abstract translation: 提供了包括电子给体和敏化化合物的组合物。 更具体地，电子给体是芳基亚磺酸盐。 还提供聚合方法，其可用于由包含烯属不饱和单体和光引发剂体系的可光聚合组合物制备聚合物材料。 光引发剂体系包括电子给体和增感化合物。

公开(公告)号：US20060111463A1

公开(公告)日：2006-05-25

申请号：US11275831

申请日：2006-01-31

Applicant: Rajdeep KALGUTKAR

Inventor： Rajdeep KALGUTKAR

IPC: C08G59/68 ,  C08F20/22

CPC classification number: C08F2/46 ,  A61K6/0017 ,  A61K6/0023 ,  A61K6/0052 ,  A61K6/083 ,  B33Y70/00 ,  C07C313/02 ,  C07C381/12 ,  C08F2/50 ,  G03F7/029 ,  C08L33/00

Abstract: Compositions are provided that include a photoinitiator system for free radical polymerization reactions. More specifically, the photoinitiator includes an arylsulfinate ion and a triarylsulfonium ion. Polymerization methods are also provided those include the photoinitiator in a photopolymerizable composition. Additionally, triarylsulfonium arylsulfinate salts are disclosed.

Abstract translation: 提供了包括用于自由基聚合反应的光引发剂体系的组合物。 更具体地说，光引发剂包括芳基亚磺酸根离子和三芳基锍离子。 还提供了包括光引发剂在可光聚合组合物中的聚合方法。 另外，公开了三芳基锍芳基亚磺酸盐。

公开(公告)号：US20160289190A1

公开(公告)日：2016-10-06

申请号：US15175824

申请日：2016-06-07

Applicant: AMGEN INC.

Inventor： Matthew BIO ,  Sebastien CAILLE ,  Brian COCHRAN ,  Yuanqing FANG ,  Brian M. FOX ,  Brian S. LUCAS ,  Lawrence R. McGEE ,  Filisaty VOUNATSOS ,  Sean H. WIEDEMANN ,  Sarah WORTMAN

IPC: C07D211/76

CPC classification number: A61K31/451 ,  C07B2200/13 ,  C07C309/04 ,  C07C309/25 ,  C07C309/35 ,  C07C313/02 ,  C07D211/76 ,  C07D211/94 ,  C07D491/048 ,  C07D498/04

Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.

公开(公告)号：US20160287570A1

公开(公告)日：2016-10-06

申请号：US15175798

申请日：2016-06-07

Applicant: AMGEN INC.

Inventor： Matthew BIO ,  Sebastien CAILLE ,  Brian COCHRAN ,  Yuanqing FANG ,  Filisaty VOUNATSOS ,  Sarah WORTMAN

IPC: A61K31/451

CPC classification number: A61K31/451 ,  C07B2200/13 ,  C07C309/04 ,  C07C309/25 ,  C07C309/35 ,  C07C313/02 ,  C07D211/76 ,  C07D211/94 ,  C07D491/048 ,  C07D498/04

Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.

公开(公告)号：US20130267732A1

公开(公告)日：2013-10-10

申请号：US13994967

申请日：2011-12-13

Applicant: Miguel A. Guerra ,  Tatsuo Fukushi ,  Zai-Ming Qiu

Inventor： Miguel A. Guerra ,  Tatsuo Fukushi ,  Zai-Ming Qiu

IPC: C07C313/02

CPC classification number: C07C313/02 ,  C07C313/04

Abstract: There is provided a process for preparing a perfluorovinyl ether sulfinate, comprising: a) providing a perfluorovinyl ether sulfonyl halide; and (b) reducing the perfluorovinyl ether sulfonyl halide with a reducing agent in an organic protic solvent.

Abstract translation: 提供了制备全氟乙烯基醚亚磺酸盐的方法，包括：a）提供全氟乙烯基醚磺酰卤; 和（b）在有机质子溶剂中用还原剂还原全氟乙烯基醚磺酰卤。

公开(公告)号：US20090203904A1

公开(公告)日：2009-08-13

申请号：US12428634

申请日：2009-04-23

Applicant: Rajdeep S. Kalgutkar ,  Michael C. Palazzotto

Inventor： Rajdeep S. Kalgutkar ,  Michael C. Palazzotto

IPC: C07D265/30 ,  C07D241/36 ,  C07D263/54 ,  C07D213/57 ,  C07C255/50

CPC classification number: A61K6/083 ,  A61K6/0017 ,  A61K6/0023 ,  A61K6/0052 ,  B33Y70/00 ,  C07C313/02 ,  C08F2/50 ,  G03F7/029 ,  C08L33/04

Abstract: Compositions are provided that include an electron donor and a sensitizing compound. More specifically, the electron donor is an arylsulfinate salt. Methods of polymerization are also provided that can be used to prepare polymeric material from a photopolymerizable composition that includes ethylenically unsaturated monomers and a photoinitiator system. The photoinitiator system includes an electron donor and a sensitizing compound.

Abstract translation: 提供了包括电子给体和敏化化合物的组合物。 更具体地，电子给体是芳基亚磺酸盐。 还提供聚合方法，其可用于由包含烯属不饱和单体和光引发剂体系的可光聚合组合物制备聚合物材料。 光引发剂体系包括电子给体和增感化合物。

公开(公告)号：US07297724B2

公开(公告)日：2007-11-20

申请号：US11275831

申请日：2006-01-31

Applicant: Rajdeep S. Kalgutkar

Inventor： Rajdeep S. Kalgutkar

IPC: C08F2/46

CPC classification number: C08F2/46 ,  A61K6/0017 ,  A61K6/0023 ,  A61K6/0052 ,  A61K6/083 ,  B33Y70/00 ,  C07C313/02 ,  C07C381/12 ,  C08F2/50 ,  G03F7/029 ,  C08L33/00

Abstract: Compositions are provided that include a photoinitiator system for free radical polymerization reactions. More specifically, the photoinitiator includes an arylsulfinate ion and a triarylsulfonium ion. Polymerization methods are also provided those include the photoinitiator in a photopolymerizable composition. Additionally, triarylsulfonium arylsulfinate salts are disclosed.

Abstract translation: 提供了包括用于自由基聚合反应的光引发剂体系的组合物。 更具体地说，光引发剂包括芳基亚磺酸根离子和三芳基锍离子。 还提供了包括光引发剂在可光聚合组合物中的聚合方法。 另外，公开了三芳基锍芳基亚磺酸盐。