公开(公告)号：US12077503B2

公开(公告)日：2024-09-03

申请号：US18239978

申请日：2023-08-30

申请人： FMC CORPORATION

发明人： Andrew Duncan Satterfield ,  Matthew James Campbell

IPC分类号： C07D211/40 ,  A01N43/36 ,  A01N43/40 ,  A01N43/46 ,  C07D207/277 ,  C07D207/46 ,  C07D211/94 ,  C07D401/04 ,  C07D401/12 ,  C07D407/04 ,  C07D409/04 ,  C07D409/12 ,  C07D413/12 ,  C07D417/04 ,  C07D471/04 ,  C07D495/04

CPC分类号： C07D211/40 ,  A01N43/36 ,  A01N43/40 ,  C07D207/277 ,  C07D207/46 ,  C07D211/94 ,  C07D401/04 ,  C07D401/12 ,  C07D407/04 ,  C07D409/12 ,  C07D413/12 ,  C07D417/04 ,  C07D471/04 ,  C07D495/04

摘要： Disclosed are compounds of Formula 1, N-oxides of the compounds and salts of the compounds and N-oxides:






wherein R1, R2, R3, R4, R5, R6, Q1, Q2, J, Y1, and Y2 are as defined in the disclosure.




Also disclosed are compositions containing the compounds, N-oxides and salts, and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of such a compound. N-oxide, salt or composition.

公开(公告)号：US20230301974A1

公开(公告)日：2023-09-28

申请号：US18313428

申请日：2023-05-08

申请人： AMGEN INC.

发明人： Matthew BIO ,  Sebastien CAILLE ,  Brian COCHRAN ,  Yuanqing FANG ,  Brian M. FOX ,  Brian S. LUCAS ,  Lawrence R. MCGEE ,  Filisaty VOUNATSOS ,  Sean H. WIEDEMANN ,  Sarah WORTMAN

IPC分类号： A61K31/451 ,  C07D211/94 ,  C07D491/048 ,  C07C309/25 ,  C07C309/04 ,  C07C313/02 ,  C07C309/35 ,  C07D498/04 ,  C07D211/76

CPC分类号： A61K31/451 ,  C07D211/94 ,  C07D491/048 ,  C07C309/25 ,  C07C309/04 ,  C07C313/02 ,  C07C309/35 ,  C07D498/04 ,  C07D211/76 ,  C07B2200/13

摘要： The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.

公开(公告)号：US20230192649A1

公开(公告)日：2023-06-22

申请号：US17986325

申请日：2022-11-14

申请人： OHIO STATE INNOVATION FOUNDATION

发明人： Daniel W. Conroy ,  Christopher P. Jaroniec

IPC分类号： C07D401/12 ,  C07D211/94 ,  C07D221/20 ,  C07D491/20 ,  G01N24/12 ,  G01R33/62

CPC分类号： C07D401/12 ,  C07D211/94 ,  C07D221/20 ,  C07D491/20 ,  G01N24/12 ,  G01R33/62

摘要： Disclosed are methods for performing dynamic nuclear polarization using the polarizing agents described herein. In general, the methods involve (a) providing a frozen sample in a magnetic field, wherein the frozen sample includes a polarizing agent described herein and an analyte with at least one spin half nucleus; (b) polarizing the at least one spin half nucleus of the analyte by irradiating the frozen sample with radiation having a frequency that excites electron spin transitions in the polarizing agent; (c) optionally melting the sample to produce a molten sample; and (d) detecting nuclear spin transitions in the at least one spin half nucleus of the analyte in the frozen or molten sample. In certain embodiments, the polarizing agents can be peptide-based. In these embodiments, the polarizing agents can be readily prepared by solid-phase peptide synthesis.

公开(公告)号：US11680046B2

公开(公告)日：2023-06-20

申请号：US17338182

申请日：2021-06-03

申请人： Celgene Corporation ,  Lundbeck La Jolla Research Center, Inc.

发明人： Lianfeng Huang ,  Nancy Tsou ,  Nicole Suzanne White ,  Jun Xu ,  Qun Zhang

IPC分类号： C07D211/94 ,  A61P35/00

CPC分类号： C07D211/94 ,  A61P35/00 ,  C07B2200/13

摘要： Provided herein are crystalline forms of (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate. Pharmaceutical compositions comprising crystalline forms of (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate are also disclosed.

公开(公告)号：US20180230127A1

公开(公告)日：2018-08-16

申请号：US15751310

申请日：2016-07-29

申请人： PFIZER INC.

发明人： DAVID RANDOLPH ANDERSON ,  Kevin Joseph CURRAN ,  Lori Krim GAVRIN ,  Joel Adam GOLDBERG ,  Arthur LEE ,  Michael Dennis LOWE ,  Akshay Patny ,  Betsy Susan PIERCE ,  Eddine SAIAH ,  John David TRZUPEK

IPC分类号： C07D401/12 ,  C07D211/94

CPC分类号： C07D401/12 ,  A61K31/437 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/519 ,  A61K2300/00 ,  C07D211/94 ,  C07D451/06

摘要： Compounds, tautomers and pharmaceutically acceptable salts of the compounds of Formula (Ia) are disclosed which are inhibitors of Interleukin-1 receptor associated kinase (IRAK4). Methods of treatment, methods of synthesis, and intermediates are also disclosed as defined in the specification.

公开(公告)号：US20180092898A1

公开(公告)日：2018-04-05

申请号：US15820830

申请日：2017-11-22

申请人： AMGEN INC.

发明人： Matthew BIO ,  Sebastien CAILLE ,  Brian COCHRAN ,  Yuanqing FANG ,  Brian M. FOX ,  Brian S. LUCAS ,  Lawrence R. MCGEE ,  Filisaty VOUNATSOS ,  Sean H. WIEDEMANN ,  Sarah WORTMAN

IPC分类号： A61K31/451 ,  C07C309/35 ,  C07C309/25 ,  C07C309/04 ,  C07C313/02 ,  C07D211/76 ,  C07D211/94 ,  C07D491/048 ,  C07D498/04

CPC分类号： A61K31/451 ,  C07B2200/13 ,  C07C309/04 ,  C07C309/25 ,  C07C309/35 ,  C07C313/02 ,  C07D211/76 ,  C07D211/94 ,  C07D491/048 ,  C07D498/04

摘要： The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.

公开(公告)号：US20180078541A1

公开(公告)日：2018-03-22

申请号：US15710249

申请日：2017-09-20

申请人： GRÜNENTHAL GMBH

发明人： FLORIAN JAKOB ,  SONJA NORDHOFF ,  DAVID RIDER ,  MARKUS WAGENER ,  GREGOR BAHRENBERG ,  TORSTEN DUNKERN

IPC分类号： A61K31/451 ,  A61K31/17 ,  A61K31/085 ,  A61K31/03

CPC分类号： A61K31/451 ,  A61K31/03 ,  A61K31/085 ,  A61K31/17 ,  A61K31/445 ,  A61K31/45 ,  A61K31/4545 ,  C07D211/16 ,  C07D211/56 ,  C07D211/94 ,  C07D401/12

摘要： The present invention relates to a compound according to general formula (I) which acts as a modulator of FPR2 and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by FPR2.

公开(公告)号：US20180072669A1

公开(公告)日：2018-03-15

申请号：US15659593

申请日：2017-07-25

申请人： Tianbiao Liu ,  Bo Hu ,  Camden DeBruler ,  Jian Luo

发明人： Tianbiao Liu ,  Bo Hu ,  Camden DeBruler ,  Jian Luo

IPC分类号： C07D213/22 ,  C07D211/94 ,  H01M8/18 ,  H01M8/04276 ,  H01M8/04746

CPC分类号： C07D213/22 ,  C07D211/94 ,  H01M8/04276 ,  H01M8/04746 ,  H01M8/188 ,  Y02E60/528

摘要： Described herein are aqueous organic redox flow batteries that include a first redox active material that can include a metallocene or a salt thereof, and a second redox active material that can include a viologen or a salt thereof. The aqueous organic redox flow batteries may further include a first aqueous electrolyte, a second aqueous electrolyte, and a separator between the first and second aqueous electrolytes. In addition, disclosed herein are methods of making the metallocene and viologen compounds.

公开(公告)号：US20170327466A1

公开(公告)日：2017-11-16

申请号：US15470739

申请日：2017-03-27

申请人： RADIKAL THERAPEUTICS INC.

发明人： Andrew Lurie Salzman ,  Prakash Jagtap ,  Garry John Southan

IPC分类号： C07D223/04 ,  C07D211/94 ,  C07D207/46

CPC分类号： C07D223/04 ,  C07D207/46 ,  C07D211/94

摘要： A method reduces oxidative stress or endothelial dysfunction in a mammal. The method includes administering to the mammal a compound of formula I: or an enantiomer, diastereomer, racemate, or a pharmaceutically acceptable salt of the compound.

公开(公告)号：US09790428B2

公开(公告)日：2017-10-17

申请号：US15364475

申请日：2016-11-30

申请人： JNC CORPORATION ,  JNC PETROCHEMICAL CORPORATION

发明人： Yasuyuki Gotoh ,  Takahiro Kobayashi

IPC分类号： G02F1/1333 ,  C09K19/54 ,  C07D211/42 ,  C07D211/94 ,  C09K19/30 ,  C09K19/34 ,  G02F1/1337

CPC分类号： C09K19/54 ,  C07D211/42 ,  C07D211/94 ,  C09K19/30 ,  C09K19/3001 ,  C09K19/3003 ,  C09K19/3068 ,  C09K19/3402 ,  C09K2019/3004 ,  C09K2019/3009 ,  C09K2019/301 ,  C09K2019/3016 ,  C09K2019/3077 ,  C09K2019/308 ,  C09K2019/3083 ,  C09K2019/3422 ,  G02F1/133365 ,  G02F1/133723 ,  G02F2001/133302 ,  G02F2202/022

摘要： Provided is a compound having an effect on preventing photolysis of a liquid crystal composition and having a high solubility in the liquid crystal composition, a liquid crystal composition containing the compound and a liquid crystal display device including the composition. The compound is represented by formula (1), the liquid crystal composition contains the compound, and the liquid crystal display device uses the composition: wherein in formula (1), R1, R2, R3 and R4 are independently hydrogen or alkyl having 1 to 4 carbons; R5 is hydrogen, hydroxy, oxy radical, alkyl having 1 to 10 carbons or alkoxy having 1 to 10 carbons; ring A1 is 1,4-cyclohexylene, 1,4-cyclohexenylene or the like; Z1 and Z2 are independently a single bond or alkylene having 1 to 10 carbons; and a is 0, 1, 2 or 3.