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公开(公告)号：US12024498B2
公开(公告)日：2024-07-02
申请号：US17986325
申请日：2022-11-14
IPC分类号： C07D401/12 , C07D211/94 , C07D221/20 , C07D491/20 , G01N24/12 , G01R33/62
CPC分类号： C07D401/12 , C07D211/94 , C07D221/20 , C07D491/20 , G01N24/12 , G01R33/62
摘要： Disclosed are methods for performing dynamic nuclear polarization using the polarizing agents described herein. In general, the methods involve (a) providing a frozen sample in a magnetic field, wherein the frozen sample includes a polarizing agent described herein and an analyte with at least one spin half nucleus; (b) polarizing the at least one spin half nucleus of the analyte by irradiating the frozen sample with radiation having a frequency that excites electron spin transitions in the polarizing agent; (c) optionally melting the sample to produce a molten sample; and (d) detecting nuclear spin transitions in the at least one spin half nucleus of the analyte in the frozen or molten sample. In certain embodiments, the polarizing agents can be peptide-based. In these embodiments, the polarizing agents can be readily prepared by solid-phase peptide synthesis.
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公开(公告)号：US20230192649A1
公开(公告)日：2023-06-22
申请号：US17986325
申请日：2022-11-14
IPC分类号： C07D401/12 , C07D211/94 , C07D221/20 , C07D491/20 , G01N24/12 , G01R33/62
CPC分类号： C07D401/12 , C07D211/94 , C07D221/20 , C07D491/20 , G01N24/12 , G01R33/62
摘要： Disclosed are methods for performing dynamic nuclear polarization using the polarizing agents described herein. In general, the methods involve (a) providing a frozen sample in a magnetic field, wherein the frozen sample includes a polarizing agent described herein and an analyte with at least one spin half nucleus; (b) polarizing the at least one spin half nucleus of the analyte by irradiating the frozen sample with radiation having a frequency that excites electron spin transitions in the polarizing agent; (c) optionally melting the sample to produce a molten sample; and (d) detecting nuclear spin transitions in the at least one spin half nucleus of the analyte in the frozen or molten sample. In certain embodiments, the polarizing agents can be peptide-based. In these embodiments, the polarizing agents can be readily prepared by solid-phase peptide synthesis.
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公开(公告)号：US11498912B2
公开(公告)日：2022-11-15
申请号：US16636530
申请日：2018-08-06
IPC分类号： C07D401/12 , C07D211/94 , C07D221/20 , C07D491/20 , G01N24/12 , G01R33/62
摘要： Disclosed are methods for performing dynamic nuclear polarization using the polarizing agents described herein. In general, the methods involve (a) providing a frozen sample in a magnetic field, wherein the frozen sample includes a polarizing agent described herein and an analyte with at least one spin half nucleus; (b) polarizing the at least one spin half nucleus of the analyte by irradiating the frozen sample with radiation having a frequency that excites electron spin transitions in the polarizing agent; (c) optionally melting the sample to produce a molten sample; and (d) detecting nuclear spin transitions in the at least one spin half nucleus of the analyte in the frozen or molten sample. In certain embodiments, the polarizing agents can be peptide-based. In these embodiments, the polarizing agents can be readily prepared by solid-phase peptide synthesis.
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