公开(公告)号：US11905237B2

公开(公告)日：2024-02-20

申请号：US17212605

申请日：2021-03-25

Applicant: The Chinese University of Hong Kong

Inventor： Ying-Yeung Yeung ,  Xiaodong Xiong ,  Tianyu Zheng ,  Xinyan Wang ,  Ying-Lung Steve Tse

IPC: C07C37/62 ,  B01J31/24 ,  C07C37/18 ,  C07F9/24 ,  C07C39/367

CPC classification number: C07C37/62 ,  B01J31/2404 ,  C07C37/18 ,  C07C39/367 ,  C07F9/2404 ,  C07B2200/09

Abstract: The subject invention pertains to a method of halogenating phenols, yielding a range of halogenated phenols with enantiomeric ratio of up to 99.5:0.5. In certain embodiments, the subject invention pertains to a method of asymmetric halogenation of bisphenol, yielding a range of chiral bisphenol ligands. The novel chiral bisphenols are potent privileged catalyst cores that can be applied to the preparation of ligands for various catalytic asymmetric reactions. The catalyst library can easily be accessed because late-stage modification of the scaffold can readily be executed through cross-coupling of the halogen handles on the bisphenols.

公开(公告)号：US11738327B2

公开(公告)日：2023-08-29

申请号：US17725830

申请日：2022-04-21

Applicant: The Government of the United States of America, as represented by the Secretary of the Navy

Inventor： R. Andrew McGill ,  Courtney A. Roberts

IPC: B01J20/00 ,  B01J20/22 ,  B01J20/282 ,  B01J20/28 ,  B01J20/34 ,  C08G59/00 ,  C08F14/06 ,  C07C39/367 ,  B01J20/281 ,  C08G64/00 ,  C08G64/10

CPC classification number: B01J20/22 ,  B01J20/281 ,  B01J20/282 ,  B01J20/28023 ,  B01J20/3425 ,  B01J20/3483 ,  C07C39/367 ,  C08F14/06 ,  C08G59/00 ,  C08G64/00 ,  C08G64/10 ,  G01N30/482 ,  B01J2220/54

Abstract: The invention relates to strong hydrogen-bond acidic sorbents. The sorbents may be provided in a form that limits or eliminates intramolecular bonding of the hydrogen-bond acidic site between neighboring sorbent molecules, for example, by providing steric groups adjacent to the hydrogen-bond acidic site. The hydrogen bond site may be a phenolic structure based on a bisphenol architecture. The sorbents of the invention may be used in methods for trapping or detecting hazardous chemicals or explosives.

公开(公告)号：US11648529B2

公开(公告)日：2023-05-16

申请号：US17725840

申请日：2022-04-21

Applicant: The Government of the United States of America, as represented by the Secretary of the Navy

Inventor： R. Andrew McGill ,  Courtney A. Roberts

IPC: B01J20/00 ,  B01J20/22 ,  B01J20/282 ,  B01J20/28 ,  B01J20/34 ,  C08G59/00 ,  C08F14/06 ,  C07C39/367 ,  B01J20/281 ,  C08G64/00 ,  C08G64/10

CPC classification number: B01J20/22 ,  B01J20/281 ,  B01J20/282 ,  B01J20/28023 ,  B01J20/3425 ,  B01J20/3483 ,  C07C39/367 ,  C08F14/06 ,  C08G59/00 ,  C08G64/00 ,  C08G64/10 ,  G01N30/482 ,  B01J2220/54

Abstract: The invention relates to strong hydrogen-bond acidic sorbents. The sorbents may be provided in a form that limits or eliminates intramolecular bonding of the hydrogen-bond acidic site between neighboring sorbent molecules, for example, by providing steric groups adjacent to the hydrogen-bond acidic site. The hydrogen bond site may be a phenolic structure based on a bisphenol architecture. The sorbents of the invention may be used in methods for trapping or detecting hazardous chemicals or explosives.

公开(公告)号：US09695135B2

公开(公告)日：2017-07-04

申请号：US14709108

申请日：2015-05-11

Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

Inventor： Edmond J. LaVoie ,  Eddy Arnold ,  Joseph D. Bauman ,  John E. Kerrigan ,  Ajit K. Parhi ,  Kalyan Das ,  Cody Kelley ,  Dishaben V. Patel

IPC: C07D257/04 ,  C07C205/22 ,  C07C255/53 ,  C07C39/15 ,  C07C39/367 ,  C07C205/26

CPC classification number: C07D257/04 ,  C07C39/15 ,  C07C39/367 ,  C07C205/22 ,  C07C205/26 ,  C07C255/53

Abstract: The invention provides compounds of formula I: and salts thereof wherein R1-R4 have any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts, and methods for their use in therapy. The compounds have useful antiviral properties.

公开(公告)号：US20170121261A1

公开(公告)日：2017-05-04

申请号：US15287483

申请日：2016-10-06

Applicant: British Columbia Cancer Agency Branch ,  The University of British Columbia

Inventor： Marianne Dorothy SADAR ,  Jun WANG ,  Nasrin R. MAWJI ,  Raymond John ANDERSEN ,  David E. WILLIAMS ,  Mike LEBLANC

IPC: C07C43/23 ,  C07C229/12

CPC classification number: C07C39/367 ,  A61K31/09 ,  A61K31/225 ,  C07B2200/07 ,  C07C43/23 ,  C07C229/12

Abstract: This invention provides compound having a structure of Formula I or Formula II. Uses of such compounds for treatment of various indications, including prostrate cancer as well as methods of treatment involving such compounds are also provided.

公开(公告)号：US09193751B2

公开(公告)日：2015-11-24

申请号：US13889980

申请日：2013-05-08

Applicant: Theracos, Inc.

Inventor： Baihua Xu ,  Binhua Lv ,  Ge Xu ,  Brian Seed ,  Jacques Y. Roberge

IPC: C07H15/04 ,  C07H7/04 ,  C07C37/00 ,  C07C41/01 ,  C07C37/16 ,  C07C41/16 ,  C07H23/00 ,  C07D309/10

CPC classification number: C07H7/04 ,  C07C37/00 ,  C07C37/16 ,  C07C41/01 ,  C07C41/16 ,  C07C2601/02 ,  C07D309/10 ,  C07H15/04 ,  C07H23/00 ,  C07C39/367 ,  C07C43/225

Abstract: Provided are methods of making compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides synthetic intermediates useful for preparing such compounds.

Abstract translation: 提供制备对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物的方法。 本发明还提供了可用于制备这些化合物的合成中间体。

公开(公告)号：US20150210634A1

公开(公告)日：2015-07-30

申请号：US14511725

申请日：2014-10-10

Applicant: Theracos, Inc.

Inventor： Jacques Roberge ,  Carine Vaxelaire ,  Baohu Liu ,  Ge Xu ,  Jian Zhang ,  Xinxing Tang ,  Baihua Xu

IPC: C07C309/75 ,  C07C41/09 ,  C07C37/50

CPC classification number: C07C309/73 ,  C07B2200/05 ,  C07B2200/13 ,  C07C37/055 ,  C07C37/50 ,  C07C41/09 ,  C07C41/16 ,  C07C41/24 ,  C07C41/26 ,  C07C41/40 ,  C07C303/28 ,  C07C309/75 ,  C07C2601/02 ,  C07C39/367 ,  C07C43/225 ,  C07C43/196

Abstract: Methods for preparing intermediates of SGLT2 inhibitors are provided, including crystalline forms and methods of crystallizing intermediates.

Abstract translation: 提供了制备SGLT2抑制剂中间体的方法，包括结晶形式和中间体结晶方法。

公开(公告)号：US20140256830A1

公开(公告)日：2014-09-11

申请号：US14199873

申请日：2014-03-06

Applicant: Ampere Life Sciences, Inc.

Inventor： Andrew W. HINMAN ,  Dana Davis ,  Viktoria Kheifets

IPC: C07C39/17 ,  C07C39/10 ,  C07C39/15

CPC classification number: A61K8/347 ,  A61K8/37 ,  A61K8/69 ,  A61K8/70 ,  A61K2800/522 ,  A61Q17/04 ,  A61Q19/02 ,  A61Q19/08 ,  C07C39/08 ,  C07C39/15 ,  C07C39/17 ,  C07C39/24 ,  C07C39/367 ,  C07C39/42 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14

Abstract: Provided herein are methods and compositions comprising resorcinol derivatives for the use of treating, regulating or preventing a skin condition characterized by oxidative stress or a degenerative process. Methods of preventing, lightening or reducing the appearance of visible discontinuities of the skin resulting from skin pigmentation, skin aging, or other disorders are also disclosed.

Abstract translation: 本文提供包含间苯二酚衍生物的方法和组合物，其用于治疗，调节或预防以氧化应激或退行过程为特征的皮肤状况。 还公开了防止，减轻或减少由皮肤色素沉着，皮肤老化或其它疾病引起的皮肤可见不连续性的外观的方法。

公开(公告)号：US20140194655A1

公开(公告)日：2014-07-10

申请号：US14237651

申请日：2012-08-08

Applicant: Junya Nakatsuji ,  Makoto Matsuura ,  Kazuhiro Yamanaka

Inventor： Junya Nakatsuji ,  Makoto Matsuura ,  Kazuhiro Yamanaka

IPC: C07C39/19 ,  C07C37/20

CPC classification number: C07C39/19 ,  C07C37/20 ,  C07C39/24 ,  C07C39/367

Abstract: Disclosed is a fluorine-containing aromatic compound represented by the following general formula (1) and its production method. In the formula (1), R1 is a hydroxyl group or amino group, each of R2 to R5 is independently a hydrogen atom, or a C1-4 straight chain or a C3 or C4 branched chain alkyl group, hydrogen atoms of the alkyl group may partially or totally be replaced with fluorine atoms, n is an integer of 0 to 2, and each of m and l is independently 0 or 1. A polymer derived from this fluorine-containing aromatic compound contains —C(CF3)2OH group at a position away from the polymer main chain. Therefore, it is useful for resist use.

Abstract translation: 公开了由以下通式（1）表示的含氟芳族化合物及其制备方法。 在式（1）中，R 1为羟基或氨基，R 2〜R 5各自独立地为氢原子或C 1-4直链或C 3或C 4支链烷基，烷基的氢原子 可以部分或全部被氟原子取代，n为0〜2的整数，m和l各自独立地为0或1.由该含氟芳香族化合物衍生的聚合物含有-C（CF 3）2 OH基， 远离聚合物主链的位置。 因此，抗蚀剂使用是有用的。

公开(公告)号：US08729136B2

公开(公告)日：2014-05-20

申请号：US13707270

申请日：2012-12-06

Applicant: Unigen, Inc.

Inventor： Qi Jia ,  Ji-Fu Zhao

IPC: A61K31/75

CPC classification number: A61K8/347 ,  A61K8/31 ,  A61K8/4973 ,  A61K8/97 ,  A61K31/015 ,  A61K31/05 ,  A61K31/085 ,  A61K31/09 ,  A61K31/357 ,  A61K31/40 ,  A61K31/704 ,  A61K2800/782 ,  A61Q19/02 ,  C07C39/15 ,  C07C39/367 ,  C07C41/26 ,  C07C41/32 ,  C07C43/23 ,  C07C45/673 ,  C07C49/835 ,  C07C215/74 ,  C07D321/12 ,  Y02A50/406 ,  Y02A50/411

Abstract: The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

Abstract translation: 本发明实现了一种将酶抑制测定与化学去除方法结合以鉴别活性植物提取物和特异性抑制双核酶功能的那些提取物中的二芳基烷烃和/或二芳基链烷醇的策略。 包括在本发明中的是由一种或多种二芳基烷烃和/或二芳基链烷醇组成的物质组合物，其抑制双核酶，特别是酪氨酸酶的活性，并且其防止黑色素过量产生。 本发明还提供了抑制双核酶，特别是酪氨酸酶的活性的方法，以及用于预防和治疗与双核酶功能相关的疾病和病症的方法。 本发明还包括一种预防和治疗与其相关的黑色素过量产生及其疾病和病症的方法。 用于预防和治疗与双核酶功能和黑色素过量产生相关的疾病和病症的方法包括向有需要的宿主施用有效量的包含一种或多种二芳基烷烃和/或二芳基链烷醇的组合物，所述二芳基烷烃和/或二芳基链烷醇合成和/或分离自 更多的植物和药学上可接受的载体。