公开(公告)号：US11472785B2

公开(公告)日：2022-10-18

申请号：US17261531

申请日：2019-05-22

申请人： AL&AM PHARMACHEM LTD.

发明人： Alexander Aizikovich

IPC分类号： C07D311/80 ,  C07C37/50 ,  C07C51/47

摘要： The present invention relates to a highly economic process for the purification of a cannabinoid acid, more specifically THCA or CBDA, from either a crude cannabis plant material or a cell culture of said cannabis plant, using ion exchange resins. The purified cannabinoid acid obtained may then be decarboxylated to yield the corresponding cannabinoid, i.e., THC or CBD, respectively.

公开(公告)号：US11407724B2

公开(公告)日：2022-08-09

申请号：US17269722

申请日：2019-08-20

申请人： Bessor Pharma, LLC

发明人： Barry A. Berkowitz ,  Anthony G. Barrett ,  Daniel Elliott

IPC分类号： C07D311/78 ,  C07C37/50 ,  C07C39/23 ,  C07D319/08 ,  C07D493/04 ,  A61K31/05 ,  A61K31/352

摘要： A process for the preparation of substantially pure diverse known and novel cannabinoids 1 and 2, which include Δ9-tetrahydrocannabinol (7), tetrahydrocannabivarin (9), cannabidiol (11), cannabidivarin (12) and other naturally occurring tetracyclic and tricyclic cannabinoids and other synthetic tetracyclic and tricyclic analogues, via intermediates 3, 6, 4 and 5, using a cascade sequence of allylic rearrangement, aromatization and, for the tetracyclic cannabinoids, further highly stereoselective and regioselective cyclization. These synthesized cannabinoids can more easily be obtained at high purity levels than cannabinoids isolated or synthesized via known methods. The cannabinoids 2, including Δ9-tetrahydrocannabinol (7), tetrahydrocannabivarin (9), are obtained containing very low levels of isomeric cannabinoids such as the undesirable Δ8-tetrahydrocannabinol. The known and novel analogues with variation in aromatic ring substituents, whilst easily synthesized with the new methodology, would be much more difficult to make from any of the components of cannabis or cannabis oil.

公开(公告)号：US11230520B2

公开(公告)日：2022-01-25

申请号：US17142751

申请日：2021-01-06

申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： Robert H. Grubbs ,  Alexey Fedorov ,  Anton Toutov ,  Kerry N. Betz

IPC分类号： C07C209/28 ,  C07C209/62 ,  C07C37/50 ,  C07C37/055 ,  C07C1/22 ,  C07C319/06 ,  C07F7/08

摘要： The present disclosure describes methods for silylating aromatic organic substrates, and associated chemical systems, said methods comprising or consisting essentially of contacting the aromatic organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate.

公开(公告)号：US20220017441A1

公开(公告)日：2022-01-20

申请号：US17294934

申请日：2019-12-02

申请人： Covestro Intellectual Property GmbH & Co. KG

发明人： Natalie Bittner ,  Jens Langanke ,  Niklas Meine ,  Jan Heijl

IPC分类号： C07C37/50 ,  C07C37/20 ,  B01J29/08 ,  C07C68/04 ,  C08G64/06

摘要： The invention relates to a process for preparing a specific hydroxy compound by means of decarboxylation of a specific carboxylic acid compound or a salt of said carboxylic acid compound, to a method for preparing a diaryl carbonate, a bisphenol or a polycarbonate, a diaryl carbonate or bisphenol, a polycarbonate, and to a method for adjusting the isotope ratio of C14 to C12 in a polymer. A specific solvent is used during decarboxylation.

公开(公告)号：US20210395176A1

公开(公告)日：2021-12-23

申请号：US17141119

申请日：2021-01-04

申请人： CV Sciences, Inc.

发明人： Michael J. Mona, III ,  Joshua A. Hartsel ,  Greg Waterbury

IPC分类号： C07C37/50 ,  C07C37/70 ,  C11B3/00 ,  C11B3/12 ,  B01D3/10 ,  B01D3/14 ,  C07C37/74 ,  C07D311/80

摘要： A method for producing hemp oil, comprising decarboxylation of CBDA in hemp oil; short-path evaporation of CBD from the decarboxylated hemp oil to produce CBD oil; selective THC to CBN conversion performed on the decarboxylated hemp oil.

公开(公告)号：US10927065B2

公开(公告)日：2021-02-23

申请号：US15889295

申请日：2018-02-06

申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： Robert H. Grubbs ,  Alexey Fedorov ,  Anton Toutov ,  Kerry N. Betz

IPC分类号： C07C209/28 ,  C07C209/62 ,  C07C1/22 ,  C07C37/055 ,  C07C319/06 ,  C07C37/50 ,  C07F7/08

摘要： The present disclosure describes methods for silylating aromatic organic substrates, and associated chemical systems, said methods comprising or consisting essentially of contacting the aromatic organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate.

公开(公告)号：US10882808B2

公开(公告)日：2021-01-05

申请号：US16512082

申请日：2019-07-15

申请人： CV SCIENCES, INC.

发明人： Michael J. Mona, III ,  Joshua A. Hartsel ,  Greg Waterbury

IPC分类号： C07C37/50 ,  C07C37/70 ,  C11B3/00 ,  C11B3/12 ,  B01D3/10 ,  B01D3/14 ,  C07C37/74 ,  C07D311/80 ,  B65D75/36 ,  B65D73/00

摘要： A method for producing hemp oil, comprising decarboxylation of CBDA in hemp oil; short-path evaporation of CBD from the decarboxylated hemp oil to produce CBD oil; selective THC to CBN conversion performed on the decarboxylated hemp oil.

公开(公告)号：US10351498B2

公开(公告)日：2019-07-16

申请号：US15141553

申请日：2016-04-28

申请人： CV SCIENCES, INC.

发明人： Michael J. Mona ,  Joshua A. Hartsel ,  Greg Waterbury

IPC分类号： B01D3/10 ,  B01D3/14 ,  C11B3/00 ,  C11B3/12 ,  B65D73/00 ,  B65D75/36 ,  C07C37/50 ,  C07C37/70 ,  C07C37/74 ,  C07D311/80

摘要： A method for producing hemp oil, comprising decarboxylation of CBDA in hemp oil; short-path evaporation of CBD from the decarboxylated hemp oil to produce CBD oil; selective THC to CBN conversion performed on the decarboxylated hemp oil.

公开(公告)号：US09908826B2

公开(公告)日：2018-03-06

申请号：US15115591

申请日：2015-01-28

申请人： University Court of the University of St. Andrews

发明人： Jennifer Julis ,  Stuart Bartlett ,  David John Cole-Hamilton

IPC分类号： C07C6/02 ,  C07C67/333 ,  C07C1/20 ,  B01J31/22 ,  C07C37/50 ,  C07C6/06 ,  C07C6/04

CPC分类号： C07C6/02 ,  B01J31/00 ,  B01J31/2226 ,  B01J31/2265 ,  B01J31/2278 ,  B01J2531/821 ,  C07C1/20 ,  C07C6/04 ,  C07C6/06 ,  C07C37/001 ,  C07C37/003 ,  C07C37/50 ,  C07C67/333 ,  C07C2531/24 ,  Y02P30/42 ,  C07C11/02 ,  C07C39/06

摘要： The invention relates to a method of alkene metathesis. In the method, at least one monoalkene is subjected to ethenolysis in the presence of a diene. The invention also relates to the use of a diene to promote an ethenolysis reaction conducted on a monoalkene.

公开(公告)号：US09670133B2

公开(公告)日：2017-06-06

申请号：US14653044

申请日：2014-06-30

申请人： SYMRISE AG

发明人： Oskar Koch ,  Marcus Rudolf Götz ,  Jan Looft ,  Tobias Vössing

IPC分类号： C07C69/94 ,  A61K31/05 ,  C07C67/29 ,  C07C37/50 ,  A61K31/235 ,  A61K31/352

CPC分类号： C07C69/94 ,  A61K31/05 ,  A61K31/235 ,  A61K31/352 ,  C07C37/50 ,  C07C67/29 ,  C07C2601/16 ,  A61K2300/00

摘要： Specific compositions comprising one or multiple (cannabinoid) compound(s) of formula (A) and/or one or multiple salt(s) thereof are described as well as methods for their manufacture. A compound of formula (A), a salt of formula (A) and a respective composition for use as medicine and for use in a method for the therapeutic treatment of the human or animal body, respectively, are also described.Furthermore, corresponding pharmaceutical formulations, cosmetic preparations and foodstuff and/or gourmet or snack preparations fit for consumption as well as a method for the manufacture of delta-9-tetrahydrocannabinol are described.