公开(公告)号：US11905237B2

公开(公告)日：2024-02-20

申请号：US17212605

申请日：2021-03-25

Applicant: The Chinese University of Hong Kong

Inventor： Ying-Yeung Yeung ,  Xiaodong Xiong ,  Tianyu Zheng ,  Xinyan Wang ,  Ying-Lung Steve Tse

IPC: C07C37/62 ,  B01J31/24 ,  C07C37/18 ,  C07F9/24 ,  C07C39/367

CPC classification number: C07C37/62 ,  B01J31/2404 ,  C07C37/18 ,  C07C39/367 ,  C07F9/2404 ,  C07B2200/09

Abstract: The subject invention pertains to a method of halogenating phenols, yielding a range of halogenated phenols with enantiomeric ratio of up to 99.5:0.5. In certain embodiments, the subject invention pertains to a method of asymmetric halogenation of bisphenol, yielding a range of chiral bisphenol ligands. The novel chiral bisphenols are potent privileged catalyst cores that can be applied to the preparation of ligands for various catalytic asymmetric reactions. The catalyst library can easily be accessed because late-stage modification of the scaffold can readily be executed through cross-coupling of the halogen handles on the bisphenols.