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公开(公告)号：US10961293B2
公开(公告)日：2021-03-30
申请号：US16344141
申请日：2017-10-26
Applicant: Janssen Pharmaceutica NV
Inventor： Mark Macielag , Raymond J. Patch , Rui Zhang , Martin A. Case , Mark J. Wall , Yue-Mei Zhang
IPC: C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00 , A61K38/00 , A61K39/00
Abstract: The present invention comprises compounds of Formula I. wherein: Z4, Z7, Z9, Z11, Z22, Z23, Z26, Z30, Z34, Z35, p, m, n, q, and BRIDGE are defined in the specification. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel compounds are useful for preventing, treating or ameliorating diseases and disorders, such as obesity, type 2 diabetes, the metabolic syndrome, insulin resistance, and dyslipidemia, among others.
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公开(公告)号：US10858413B2
公开(公告)日：2020-12-08
申请号：US16344263
申请日：2017-10-26
Applicant: Janssen Pharmaceutica NV
Inventor： Mark Macielag , Raymond J. Patch , Rui Zhang , Martin A. Case , Mark J. Wall , Yue-Mei Zhang , Shamina M. Rangwala , James N. Leonard , Raul C. Camacho , Michael J. Hunter , Katharine E. D'Aquino , Wilson Edwards , Ronald V. Swanson , Wenying Jian , Ellen Chi
IPC: C07K14/575 , A61K47/68 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , C07K16/24 , A61K9/00 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61K45/06 , C07K16/00 , A61K38/00 , A61K39/00
Abstract: The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.
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公开(公告)号：US11591379B2
公开(公告)日：2023-02-28
申请号：US16820174
申请日：2020-03-16
Applicant: Janssen Pharmaceutica NV
Inventor： Mark Macielag , Raymond J. Patch , Rui Zhang , Martin A. Case , Shamina M. Rangwala , James N. Leonard , Raul C. Camacho , Michael J. Hunter , Katharine E. D'Aquino , Wilson Edwards , Ronald V. Swanson , Wenying Jian , Yue-Mei Zhang , Mark J. Wall , Ellen Chi
IPC: C07K14/575 , A61K47/68 , C07K16/24 , A61K38/17 , A61K38/26 , A61K47/64 , A61P3/10 , A61K47/60 , A61P3/08 , A61P3/04 , A61P3/06 , A61K38/22 , A61K9/00 , C07K1/06 , C07K1/107 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61P3/00 , A61K45/06 , C07K16/00 , A61K38/00 , A61K39/00
Abstract: The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.
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公开(公告)号：US20180127476A1
公开(公告)日：2018-05-10
申请号：US15794231
申请日：2017-10-26
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： Mark Macielag , Raymond J. Patch , Rui Zhang , Martin A. Case , Yue-Mei Zhang , Mark Wall
Abstract: The present invention comprises compounds of Formula I. wherein: Z4, Z7, Z9, Z11, Z22, Z23, Z26, Z30, Z34, Z35, p, m, n, q, and BRIDGE are defined in the specification. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel compounds are useful for preventing, treating or ameliorating diseases and disorders, such as obesity, type 2 diabetes, the metabolic syndrome, insulin resistance, and dyslipidemia, among others.
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公开(公告)号：US11732019B2
公开(公告)日：2023-08-22
申请号：US17168325
申请日：2021-02-05
Applicant: Janssen Pharmaceutica NV
Inventor： Mark Macielag , Raymond J. Patch , Rui Zhang , Martin A. Case , Mark J. Wall , Yue-Mei Zhang
IPC: C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00 , A61K38/00 , A61K39/00
CPC classification number: C07K14/575 , A61K9/0019 , A61K38/17 , A61K38/1709 , A61K38/22 , A61K38/26 , A61K45/06 , A61K47/60 , A61K47/64 , A61K47/68 , A61K47/6811 , A61K47/6845 , A61K47/6883 , A61K49/0032 , A61K49/0052 , A61K49/0056 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , C07K1/061 , C07K1/1072 , C07K1/12 , C07K1/18 , C07K5/0205 , C07K14/57545 , C07K16/00 , C07K16/24 , A61K38/00 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/92 , C07K2317/94 , C07K2319/30
Abstract: The present invention comprises compounds of Formula I.
wherein:
Z4, Z7, Z9, Z11, Z22, Z23, Z26, Z30, Z34, Z35, p, m, n, q, and BRIDGE are defined in the specification. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel compounds are useful for preventing, treating or ameliorating diseases and disorders, such as obesity, type 2 diabetes, the metabolic syndrome, insulin resistance, and dyslipidemia, among others.-
Patent Agency Ranking
公开(公告)号：US09193736B2
公开(公告)日：2015-11-24
申请号：US14299451
申请日：2014-06-09
Applicant: Janssen Pharmaceutica, NV
Inventor： Mark R. Player , Sanath K. Meegalla , Carl R. Illig , Jinsheng Chen , Kenneth J. Wilson , Yu-Kai Lee , Daniel J. Parks , Wing S. Cheung , Hui Huang , Raymond J. Patch
IPC: C07D487/04
CPC classification number: C07D487/04
Abstract: Disclosed are compounds, compositions and methods for treating Type II diabetes. Such compounds are represented by Formula (I) as follows: wherein R1, R2, L, and Q are defined herein.
Abstract translation: 公开了用于治疗II型糖尿病的化合物，组合物和方法。 这样的化合物由式（I）表示如下：其中R1，R2，L和Q在本文中定义。
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公开(公告)号：US10787495B2
公开(公告)日：2020-09-29
申请号：US16542751
申请日：2019-08-16
Applicant: Janssen Pharmaceutica NV
Inventor： Mark Macielag , Raymond J. Patch , Rui Zhang , Martin A. Case , Shamina M. Rangwala , James N. Leonard , Raul C. Camacho , Michael J. Hunter , Katharine E. D'Aquino , Wilson Edwards , Ronald V. Swanson , Wenying Jian , Yue-Mei Zhang , Mark J. Wall , Ellen Chi
IPC: A61K47/00 , A61K47/60 , C07K16/00 , A61K39/00 , A61K39/395 , A61K38/12 , A61K38/26 , C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , A61K38/00
Abstract: The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.
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公开(公告)号：US12134636B2
公开(公告)日：2024-11-05
申请号：US17085128
申请日：2020-10-30
Applicant: Janssen Pharmaceutica NV
Inventor： Mark Macielag , Raymond J. Patch , Rui Zhang , Martin A. Case , Mark J. Wall , Yue-Mei Zhang , Shamina M. Rangwala , James N. Leonard , Raul C. Camacho , Michael J. Hunter , Katharine E. D'Aquino , Wilson Edwards , Ronald V. Swanson , Wenying Jian , Ellen Chi
IPC: A61K39/395 , A61K9/00 , A61K38/17 , A61K38/22 , A61K38/26 , A61K45/06 , A61K47/60 , A61K47/64 , A61K47/68 , A61K49/00 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , C07K1/06 , C07K1/107 , C07K1/12 , C07K1/18 , C07K5/02 , C07K14/575 , C07K16/00 , C07K16/24 , A61K38/00 , A61K39/00
Abstract: The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.
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公开(公告)号：US11767354B2
公开(公告)日：2023-09-26
申请号：US17168503
申请日：2021-02-05
Applicant: Janssen Pharmaceutica NV
Inventor： Mark Macielag , Raymond J. Patch , Rui Zhang , Martin A. Case , Shamina M. Rangwala , James N. Leonard , Raul C. Camacho , Michael J. Hunter , Katharine E. D'Aquino , Wilson Edwards , Ronald V. Swanson , Wenying Jian , Yue-Mei Zhang , Mark J. Wall , Ellen Chi
IPC: C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00 , A61K38/00 , A61K39/00
CPC classification number: C07K14/575 , A61K9/0019 , A61K38/17 , A61K38/1709 , A61K38/22 , A61K38/26 , A61K45/06 , A61K47/60 , A61K47/64 , A61K47/68 , A61K47/6811 , A61K47/6845 , A61K47/6883 , A61K49/0032 , A61K49/0052 , A61K49/0056 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , C07K1/061 , C07K1/1072 , C07K1/12 , C07K1/18 , C07K5/0205 , C07K14/57545 , C07K16/00 , C07K16/24 , A61K38/00 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/92 , C07K2317/94 , C07K2319/30
Abstract: The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.
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10.发明授权公开(公告)号：US10968265B2
公开(公告)日：2021-04-06
申请号：US16344174
申请日：2017-10-26
Applicant: Janssen Pharmaceutica NV
Inventor： Mark Macielag , Raymond J. Patch , Rui Zhang , Martin A. Case , Shamina M. Rangwala , James N. Leonard , Raul C. Camacho , Michael J. Hunter , Katharine E. D'Aquino , Wilson Edwards , Ronald V. Swanson , Wenying Jian , Yue-Mei Zhang , Mark J. Wall , Ellen Chi
IPC: C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00 , A61K38/00 , A61K39/00
Abstract: The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.
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