公开(公告)号：US11591379B2

公开(公告)日：2023-02-28

申请号：US16820174

申请日：2020-03-16

Applicant: Janssen Pharmaceutica NV

Inventor： Mark Macielag ,  Raymond J. Patch ,  Rui Zhang ,  Martin A. Case ,  Shamina M. Rangwala ,  James N. Leonard ,  Raul C. Camacho ,  Michael J. Hunter ,  Katharine E. D'Aquino ,  Wilson Edwards ,  Ronald V. Swanson ,  Wenying Jian ,  Yue-Mei Zhang ,  Mark J. Wall ,  Ellen Chi

IPC: C07K14/575 ,  A61K47/68 ,  C07K16/24 ,  A61K38/17 ,  A61K38/26 ,  A61K47/64 ,  A61P3/10 ,  A61K47/60 ,  A61P3/08 ,  A61P3/04 ,  A61P3/06 ,  A61K38/22 ,  A61K9/00 ,  C07K1/06 ,  C07K1/107 ,  A61K49/00 ,  C07K1/12 ,  C07K1/18 ,  C07K5/02 ,  A61P3/00 ,  A61K45/06 ,  C07K16/00 ,  A61K38/00 ,  A61K39/00

Abstract: The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.

公开(公告)号：US10858413B2

公开(公告)日：2020-12-08

申请号：US16344263

申请日：2017-10-26

Applicant: Janssen Pharmaceutica NV

Inventor： Mark Macielag ,  Raymond J. Patch ,  Rui Zhang ,  Martin A. Case ,  Mark J. Wall ,  Yue-Mei Zhang ,  Shamina M. Rangwala ,  James N. Leonard ,  Raul C. Camacho ,  Michael J. Hunter ,  Katharine E. D'Aquino ,  Wilson Edwards ,  Ronald V. Swanson ,  Wenying Jian ,  Ellen Chi

IPC: C07K14/575 ,  A61K47/68 ,  A61K38/17 ,  A61K38/26 ,  C07K1/06 ,  C07K1/107 ,  A61K47/64 ,  A61P3/10 ,  A61P3/08 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61K38/22 ,  C07K16/24 ,  A61K9/00 ,  A61K49/00 ,  C07K1/12 ,  C07K1/18 ,  C07K5/02 ,  A61K47/60 ,  A61K45/06 ,  C07K16/00 ,  A61K38/00 ,  A61K39/00

Abstract: The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.

公开(公告)号：US10787495B2

公开(公告)日：2020-09-29

申请号：US16542751

申请日：2019-08-16

Applicant: Janssen Pharmaceutica NV

Inventor： Mark Macielag ,  Raymond J. Patch ,  Rui Zhang ,  Martin A. Case ,  Shamina M. Rangwala ,  James N. Leonard ,  Raul C. Camacho ,  Michael J. Hunter ,  Katharine E. D'Aquino ,  Wilson Edwards ,  Ronald V. Swanson ,  Wenying Jian ,  Yue-Mei Zhang ,  Mark J. Wall ,  Ellen Chi

IPC: A61K47/00 ,  A61K47/60 ,  C07K16/00 ,  A61K39/00 ,  A61K39/395 ,  A61K38/12 ,  A61K38/26 ,  C07K14/575 ,  A61K47/68 ,  C07K16/24 ,  A61K9/00 ,  A61K38/17 ,  C07K1/06 ,  C07K1/107 ,  A61K47/64 ,  A61P3/10 ,  A61K49/00 ,  C07K1/12 ,  C07K1/18 ,  C07K5/02 ,  A61P3/08 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61K38/22 ,  A61K45/06 ,  A61K38/00

Abstract: The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.

公开(公告)号：US12134636B2

公开(公告)日：2024-11-05

申请号：US17085128

申请日：2020-10-30

Applicant: Janssen Pharmaceutica NV

Inventor： Mark Macielag ,  Raymond J. Patch ,  Rui Zhang ,  Martin A. Case ,  Mark J. Wall ,  Yue-Mei Zhang ,  Shamina M. Rangwala ,  James N. Leonard ,  Raul C. Camacho ,  Michael J. Hunter ,  Katharine E. D'Aquino ,  Wilson Edwards ,  Ronald V. Swanson ,  Wenying Jian ,  Ellen Chi

IPC: A61K39/395 ,  A61K9/00 ,  A61K38/17 ,  A61K38/22 ,  A61K38/26 ,  A61K45/06 ,  A61K47/60 ,  A61K47/64 ,  A61K47/68 ,  A61K49/00 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/08 ,  A61P3/10 ,  C07K1/06 ,  C07K1/107 ,  C07K1/12 ,  C07K1/18 ,  C07K5/02 ,  C07K14/575 ,  C07K16/00 ,  C07K16/24 ,  A61K38/00 ,  A61K39/00

Abstract: The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.

公开(公告)号：US11767354B2

公开(公告)日：2023-09-26

申请号：US17168503

申请日：2021-02-05

Applicant: Janssen Pharmaceutica NV

Inventor： Mark Macielag ,  Raymond J. Patch ,  Rui Zhang ,  Martin A. Case ,  Shamina M. Rangwala ,  James N. Leonard ,  Raul C. Camacho ,  Michael J. Hunter ,  Katharine E. D'Aquino ,  Wilson Edwards ,  Ronald V. Swanson ,  Wenying Jian ,  Yue-Mei Zhang ,  Mark J. Wall ,  Ellen Chi

IPC: C07K14/575 ,  A61K47/68 ,  C07K16/24 ,  A61K9/00 ,  A61K38/17 ,  A61K38/26 ,  C07K1/06 ,  C07K1/107 ,  A61K47/64 ,  A61P3/10 ,  A61K49/00 ,  C07K1/12 ,  C07K1/18 ,  C07K5/02 ,  A61K47/60 ,  A61P3/08 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61K38/22 ,  A61K45/06 ,  C07K16/00 ,  A61K38/00 ,  A61K39/00

CPC classification number: C07K14/575 ,  A61K9/0019 ,  A61K38/17 ,  A61K38/1709 ,  A61K38/22 ,  A61K38/26 ,  A61K45/06 ,  A61K47/60 ,  A61K47/64 ,  A61K47/68 ,  A61K47/6811 ,  A61K47/6845 ,  A61K47/6883 ,  A61K49/0032 ,  A61K49/0052 ,  A61K49/0056 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/08 ,  A61P3/10 ,  C07K1/061 ,  C07K1/1072 ,  C07K1/12 ,  C07K1/18 ,  C07K5/0205 ,  C07K14/57545 ,  C07K16/00 ,  C07K16/24 ,  A61K38/00 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/71 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/30

Abstract: The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.

公开(公告)号：US10968265B2

公开(公告)日：2021-04-06

申请号：US16344174

申请日：2017-10-26

Applicant: Janssen Pharmaceutica NV

Inventor： Mark Macielag ,  Raymond J. Patch ,  Rui Zhang ,  Martin A. Case ,  Shamina M. Rangwala ,  James N. Leonard ,  Raul C. Camacho ,  Michael J. Hunter ,  Katharine E. D'Aquino ,  Wilson Edwards ,  Ronald V. Swanson ,  Wenying Jian ,  Yue-Mei Zhang ,  Mark J. Wall ,  Ellen Chi

IPC: C07K14/575 ,  A61K47/68 ,  C07K16/24 ,  A61K9/00 ,  A61K38/17 ,  A61K38/26 ,  C07K1/06 ,  C07K1/107 ,  A61K47/64 ,  A61P3/10 ,  A61K49/00 ,  C07K1/12 ,  C07K1/18 ,  C07K5/02 ,  A61K47/60 ,  A61P3/08 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61K38/22 ,  A61K45/06 ,  C07K16/00 ,  A61K38/00 ,  A61K39/00

Abstract: The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.

公开(公告)号：US20180125998A1

公开(公告)日：2018-05-10

申请号：US15794250

申请日：2017-10-26

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： Mark Macielag ,  Raymond J. Patch ,  Rui Zhang ,  Martin A. Case ,  Shamina M. Rangwala ,  James N. Leonard ,  Raul C. Camacho ,  Michael J. Hunter ,  Katharine E. D'Aquino ,  Wilson Edwards ,  Ronald V. Swanson ,  Wenying Jian ,  Yue-Mei Zhang ,  Mark Wall ,  Ellen Chi

IPC: A61K47/68 ,  C07K16/00 ,  A61K47/60 ,  A61K38/22 ,  A61P3/04

Abstract: The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.