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公开(公告)号：US10000502B2
公开(公告)日：2018-06-19
申请号：US15403741
申请日：2017-01-11
发明人： Gilles Bignan , Peter J Connolly , Ian Hickson , Lieven Meerpoel , Vineet Pande , Zhuming Zhang , Jonathan Branch , Christian Rocaboy , Luis B Trabalón Escolar
IPC分类号： C07D491/107 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D409/14 , C07D451/02 , C07D451/06 , C07D487/04 , C07D491/044 , C07D491/048 , A61K9/00 , A61K31/4439 , A61K31/4545 , A61K31/46 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/573 , A61K31/58
CPC分类号： C07D491/107 , A61K9/0053 , A61K31/4439 , A61K31/4545 , A61K31/46 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/573 , A61K31/58 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D451/02 , C07D451/06 , C07D487/04 , C07D491/044 , C07D491/048
摘要： Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1 and G are defined herein.
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公开(公告)号：US20190337924A1
公开(公告)日：2019-11-07
申请号：US16440937
申请日：2019-06-13
发明人： Gilles Bignan , Peter J Connolly , Jan Hickson , Lieven Meerpoel , Vineet Pande , Zhuming Zhang , Jonathan Branch , Christian Rocaboy , Luis B Trabalón Escolar
IPC分类号： C07D401/14 , A61K31/58 , A61K31/4545 , C07D401/12 , A61K31/573 , A61K31/454
摘要： Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1a, R2a, R2b, Z, X, Y, and G are defined herein.
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3.发明授权Benzamide derivative useful as FASN inhibitors for the treatment of cancer 有权苯甲酰胺衍生物可用作治疗癌症的FASN抑制剂公开(公告)号：US09562035B2
公开(公告)日：2017-02-07
申请号：US14550349
申请日：2014-11-21
发明人： Peter J Connolly , Tianbao Lu
IPC分类号： C07D401/14 , C07D487/04 , C07D417/14 , C07D413/14 , C07D401/10 , C07D409/14 , C07D405/14 , A61K31/5377 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/4709 , C07D401/12 , C07D403/10 , C07D471/04 , A61K31/437 , A61K31/454 , A61K31/4545
CPC分类号： C07D401/14 , A61K31/437 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , C07D401/10 , C07D401/12 , C07D403/10 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention is directed to benzamide derivatives, pharmaceutical compositions containing them, and their use as FASN inhibitors, in for example, the treatment of cancer, obesity related disorders, liver related disorders and viral infections. Such compounds are represented by formula (I) as follows: wherein R1, R2, R3, R4, R5, m, n, are defined herein.
摘要翻译： 本发明涉及苯甲酰胺衍生物，含有它们的药物组合物及其作为FASN抑制剂的用途，例如治疗癌症，肥胖相关疾病，肝脏相关病症和病毒感染。 这样的化合物由式（I）表示如下：其中R 1，R 2，R 3，R 4，R 5，m，n在本文中定义。
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公开(公告)号：US10413545B2
公开(公告)日：2019-09-17
申请号：US15631167
申请日：2017-06-23
发明人： Peter J Connolly , Tianbao Lu
IPC分类号： A61K31/517 , C07D417/14 , C07D401/14 , C07D413/14 , C07D405/14 , C07D403/14 , C07D403/06 , A61K31/4178 , A61K31/423 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61P1/16 , A61P3/06 , A61P3/04 , A61P3/10
摘要： The present invention is directed to imidazolin-5-one derivatives, pharmaceutical compositions containing them, and their use as FASN inhibitors, in for example, the treatment of cancer, obesity related disorders, and liver related disorders. Such compounds are represented by formula (I) as follows: wherein R1, R2, R3, R4, R5, m, n, and are defined herein.
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公开(公告)号：US09718813B2
公开(公告)日：2017-08-01
申请号：US14573012
申请日：2014-12-17
发明人： Peter J Connolly , Tianbao Lu
IPC分类号： C07D403/14 , C07D417/14 , C07D401/14 , C07D413/14 , C07D405/14 , C07D403/06
CPC分类号： A61K31/517 , A61K31/4178 , A61K31/423 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/10 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to imidazolin-5-one derivatives, pharmaceutical compositions containing them, and their use as FASN inhibitors, in for example, the treatment of cancer, obesity related disorders, and liver related disorders. Such compounds are represented by formula (I) as follows: wherein R1, R2, R3, R4, R5, m, n, and are defined herein.
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6.发明申请公开(公告)号：US20160009688A1
公开(公告)日：2016-01-14
申请号：US14550349
申请日：2014-11-21
发明人： Peter J Connolly , Tianbao Lu
IPC分类号： C07D401/14 , A61K31/5377 , A61K31/496 , A61K31/506 , C07D487/04 , A61K31/4709 , A61K31/4545 , C07D417/14 , A61K31/454 , C07D413/14 , A61K31/437 , C07D401/10 , C07D409/14 , C07D405/14 , A61K31/4725
CPC分类号： C07D401/14 , A61K31/437 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , C07D401/10 , C07D401/12 , C07D403/10 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention is directed to benzamide derivatives, pharmaceutical compositions containing them, and their use as FASN inhibitors, in for example, the treatment of cancer, obesity related disorders, liver related disorders and viral infections. Such compounds are represented by formula (I) as follows: wherein R1, R2, R3, R4, R5, m, n, are defined herein.
摘要翻译： 本发明涉及苯甲酰胺衍生物，含有它们的药物组合物及其作为FASN抑制剂的用途，例如治疗癌症，肥胖相关疾病，肝脏相关病症和病毒感染。 这样的化合物由式（I）表示如下：其中R 1，R 2，R 3，R 4，R 5，m，n在本文中定义。
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公开(公告)号：US08962607B2
公开(公告)日：2015-02-24
申请号：US13867372
申请日：2013-04-22
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Peter J Connolly , Christopher Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark M McDonnell , Philip M Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/496 , A61K31/55 , A61K31/5377 , A61K31/519 , A61K31/506 , A61K31/541 , C07D405/12 , C07D417/14 , C07D409/14 , C07D411/14 , C07D471/04 , C07D495/04 , C07D491/048 , C07D413/14 , C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D403/12 , C07D403/14 , C07D417/12 , C07D409/06 , C07D417/06 , C07D403/06 , C07D409/12 , C07D401/14 , C07D403/04
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式（I）表示如下：其中Y，Z，R 1和S在本文中定义。
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公开(公告)号：US08722658B2
公开(公告)日：2014-05-13
申请号：US13749846
申请日：2013-01-25
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Peter J Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/496 , C07D295/192 , C07D401/06 , C07D403/12
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
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