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公开(公告)号：US20140243305A1
公开(公告)日：2014-08-28
申请号：US13867372
申请日：2013-04-22
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Peter J. Connolly , Christopher Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark M. McDonnell , Philip M. Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： C07D417/12 , C07D405/12 , C07D417/14 , C07D401/12 , C07D409/12 , C07D205/04 , C07D403/12
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式（I）表示如下：其中Y，Z，R 1和S在本文中定义。
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2.发明授权Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitors 有权作为单酰基甘油脂肪酶抑制剂的杂芳族和芳族哌嗪基氮杂环丁烷基酰胺公开(公告)号：US08815839B2
公开(公告)日：2014-08-26
申请号：US13784036
申请日：2013-03-04
发明人： Kristen Chevalier , Jose Clemente , Scott L Dax , Chris Flores , Li Liu , Mark J Macielag , Mark McDonnell , Marina Nelen , Erica Nulton , Stephen Prouty , Matthew Todd , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/496 , A61K31/551 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12
CPC分类号： C07D403/12 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Disclosed are compounds, compositions and methods for treating diseases, syndromes, conditions and disorders that are affected by the inhibition of MGL, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, r, R2 and Z are defined herein.
摘要翻译： 公开了用于治疗受到抑制MGL（包括疼痛）的疾病，综合征，病症和障碍的化合物，组合物和方法。 这样的化合物由式（I）表示如下：其中Y，r，R 2和Z如本文所定义。
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公开(公告)号：US08741887B2
公开(公告)日：2014-06-03
申请号：US13718056
申请日：2012-12-18
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/496 , C07D401/12 , C07D403/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D495/04
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
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公开(公告)号：US08691805B2
公开(公告)日：2014-04-08
申请号：US13874835
申请日：2013-05-01
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/517 , A61K31/506 , A61K31/496 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
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公开(公告)号：US20130137674A1
公开(公告)日：2013-05-30
申请号：US13749846
申请日：2013-01-25
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Peter Connolly , Christopher Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： C07D417/14 , C07D403/14 , C07D409/14 , C07D403/04 , C07D401/14
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
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公开(公告)号：US08962607B2
公开(公告)日：2015-02-24
申请号：US13867372
申请日：2013-04-22
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Peter J Connolly , Christopher Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark M McDonnell , Philip M Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/496 , A61K31/55 , A61K31/5377 , A61K31/519 , A61K31/506 , A61K31/541 , C07D405/12 , C07D417/14 , C07D409/14 , C07D411/14 , C07D471/04 , C07D495/04 , C07D491/048 , C07D413/14 , C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D403/12 , C07D403/14 , C07D417/12 , C07D409/06 , C07D417/06 , C07D403/06 , C07D409/12 , C07D401/14 , C07D403/04
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式（I）表示如下：其中Y，Z，R 1和S在本文中定义。
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公开(公告)号：US08895573B2
公开(公告)日：2014-11-25
申请号：US13766046
申请日：2013-02-13
发明人： Steven J Coats , Yue-Mei Zhang , Shu-Chen Lin , Li Liu , Tamara A Miskowski , Scott L. Dax , Henry J Breslin , Bart L. De Corte , Wei He
IPC分类号： A01N43/54 , A61K31/505 , C07D401/12 , A61K31/506 , C07D417/12 , C07D403/12 , C07D413/12 , C07D239/28 , C07D239/52 , C07D239/34
CPC分类号： C07D239/52 , A61K31/506 , C07D239/28 , C07D239/34 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, Y, R2, R3, and Ra are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，Y，R2，R3和Ra在本文中定义。
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公开(公告)号：US08722658B2
公开(公告)日：2014-05-13
申请号：US13749846
申请日：2013-01-25
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Peter J Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/496 , C07D295/192 , C07D401/06 , C07D403/12
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
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公开(公告)号：US08685990B2
公开(公告)日：2014-04-01
申请号：US13950952
申请日：2013-07-25
发明人： Steven J. Coats , Haiyan Bian , Peter J. Connolly , Gilles Bignan , Chaozhong Cai , Scott L. Dax , Bart L. DeCorte , Shu-Chen Lin , Li Liu , Mark J. Macielag , Philip M. Pitis , Yue-Mei Zhang , Bin Zhu , Wei He
IPC分类号： A01N43/54
CPC分类号： C07D239/47 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, and L, A, and Ra are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，R2，R3和L，A和Ra在本文中定义。
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公开(公告)号：US20140066422A1
公开(公告)日：2014-03-06
申请号：US13766046
申请日：2013-02-13
发明人： Steven J. Coats , Yue-Mei Zhang , Shu-Chen Lin , Li Liu , Tamara A. Miskowski , Scott L. Dax , Henry J Breslin , Bart L. De Corte , Wei He
IPC分类号： C07D239/52 , C07D403/12 , C07D417/12 , C07D401/12
CPC分类号： C07D239/52 , A61K31/506 , C07D239/28 , C07D239/34 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, Y, R2, R3, and Ra are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，Y，R2，R3和Ra在本文中定义。
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