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公开(公告)号：US20130137674A1
公开(公告)日：2013-05-30
申请号：US13749846
申请日：2013-01-25
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Peter Connolly , Christopher Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： C07D417/14 , C07D403/14 , C07D409/14 , C07D403/04 , C07D401/14
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
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公开(公告)号：US20140162997A1
公开(公告)日：2014-06-12
申请号：US13968465
申请日：2013-08-16
发明人： Mark Wall , Nalin Subasinghe , Zhihua Sui , Christopher Flores
IPC分类号： C07D231/22 , C07D413/14 , C07D409/12 , C07D403/12 , C07D401/12 , C07D405/12
CPC分类号： C07D231/22 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, ring A, and G are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，R2，环A和G如本文所定义。
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公开(公告)号：US20130217669A1
公开(公告)日：2013-08-22
申请号：US13845982
申请日：2013-03-18
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Christopher Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： C07D417/14 , C07D403/10 , C07D409/06 , C07D401/10 , C07D205/04 , C07D417/06
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
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公开(公告)号：US20180161312A1
公开(公告)日：2018-06-14
申请号：US15892846
申请日：2018-02-09
发明人： Ishtiyaque Ahmad , Rajagopal Bakthavatchalam , Sivaramakrishna Battula , Henricus Jacobus Maria Gijsen , Saravanan Vadivelu , Mark Wall , Christopher Flores
IPC分类号： A61K31/4178 , A61K31/506 , A61K31/497 , A61K31/444 , C07D405/14 , A61K31/4196 , C07D405/04 , A61K31/4439
CPC分类号： A61K31/4178 , A61K31/4196 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , C07D405/04 , C07D405/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, and G are defined herein.
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公开(公告)号：US08962607B2
公开(公告)日：2015-02-24
申请号：US13867372
申请日：2013-04-22
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Peter J Connolly , Christopher Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark M McDonnell , Philip M Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/496 , A61K31/55 , A61K31/5377 , A61K31/519 , A61K31/506 , A61K31/541 , C07D405/12 , C07D417/14 , C07D409/14 , C07D411/14 , C07D471/04 , C07D495/04 , C07D491/048 , C07D413/14 , C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D403/12 , C07D403/14 , C07D417/12 , C07D409/06 , C07D417/06 , C07D403/06 , C07D409/12 , C07D401/14 , C07D403/04
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式（I）表示如下：其中Y，Z，R 1和S在本文中定义。
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公开(公告)号：US08853418B2
公开(公告)日：2014-10-07
申请号：US13968470
申请日：2013-08-16
发明人： Michael Winters , Zhihua Sui , Christopher Flores
IPC分类号： A61K31/695 , C07D231/56 , C07D401/12 , C07D231/54 , C07D405/12 , C07F7/18 , C07D405/04 , C07D401/04 , C07D403/04 , C07D491/113 , A61K31/416
CPC分类号： C07D231/54 , A61K31/416 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/12 , C07D491/113 , C07F7/1804
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, Q, and G are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式（I）表示如下：其中R1，R2，R3，Q和G如本文所定义。
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公开(公告)号：US10653673B2
公开(公告)日：2020-05-19
申请号：US15892846
申请日：2018-02-09
发明人： Ishtiyaque Ahmad , Rajagopal Bakthavatchalam , Sivaramakrishna Battula , Henricus Jacobus Maria Gijsen , Saravanan Vadivelu , Mark Wall , Christopher Flores
IPC分类号： A61K31/4178 , C07D405/14 , C07D405/04 , A61K31/4196 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, and G are defined herein.
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公开(公告)号：US20140243305A1
公开(公告)日：2014-08-28
申请号：US13867372
申请日：2013-04-22
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Peter J. Connolly , Christopher Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark M. McDonnell , Philip M. Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： C07D417/12 , C07D405/12 , C07D417/14 , C07D401/12 , C07D409/12 , C07D205/04 , C07D403/12
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式（I）表示如下：其中Y，Z，R 1和S在本文中定义。
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公开(公告)号：US09974775B2
公开(公告)日：2018-05-22
申请号：US15202600
申请日：2016-07-06
发明人： Ishtiyaque Ahmad , Rajagopal Bakthavatchalam , Sivaramakrishna Battula , Henricus Jacobus Maria Gijsen , Saravanan Vadivelu , Mark Wall , Christopher Flores
IPC分类号： A61K31/4178 , C07D405/14 , C07D405/04 , A61K31/4196 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506
CPC分类号： A61K31/4178 , A61K31/4196 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , C07D405/04 , C07D405/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, and G are defined herein.
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公开(公告)号：US09434693B2
公开(公告)日：2016-09-06
申请号：US13968465
申请日：2013-08-16
发明人： Mark Wall , Nalin Subasinghe , Zhihua Sui , Christopher Flores
IPC分类号： A61K31/00 , A61K31/415 , A61K31/445 , A61K31/42 , C07D401/00 , C07D231/00 , C07D403/00 , C07D403/02 , C07D261/00 , C07D413/00 , C07D231/22 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/14
CPC分类号： C07D231/22 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, ring A, and G are defined herein.
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