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公开(公告)号：US20220267298A1
公开(公告)日：2022-08-25
申请号：US17630537
申请日：2020-07-29
发明人： Guozhang Xu , Micheal D. Gaul
IPC分类号： C07D401/10 , C07D403/10 , C07D405/14 , C07D401/14 , C07D413/14 , C07D409/14 , C07D471/04
摘要： The present invention is directed to quinazolin-4-one derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by GRK2, including the treatment of for example, cardiac failure, cardiac hypertrophy, hypertension, Type II diabetes Mellitus, NASH, NAFLD, End-stage kidney disease, kidney failure, etc.
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公开(公告)号：US20220009906A1
公开(公告)日：2022-01-13
申请号：US17356575
申请日：2021-06-24
发明人： Guozhang Xu , Eugene B. Grant , Gee-Hong Kuo , Micheal D. Gaul
IPC分类号： C07D403/04 , C07D409/14 , C07D403/14 , C07D405/14 , C07D401/14 , C07D471/10 , C07D491/107 , C07D498/10
摘要： The present invention is directed to isoindolin-1-one derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by GRK2, including, but not limited to, cardiac failure, cardiac hypertrophy, hypertension, Type II diabetes Mellitus, NASH, NAFLD, end stage chronic kidney disease, kidney failure, etc.
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公开(公告)号：US20220306632A1
公开(公告)日：2022-09-29
申请号：US17696925
申请日：2022-03-17
发明人： Guozhang Xu , Zhijie Liu , Micheal D. Gaul
IPC分类号： C07D471/14 , C07D471/04
摘要： The present invention is directed to bicyclic pyridine N-oxide derivatives, stereoisomers, isotopologues, isotopomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.
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4.发明授权Substituted piperidinyl-carboxamide derivatives useful as SCD 1 inhibitors 有权用作SCD 1抑制剂的取代的哌啶基 - 甲酰胺衍生物公开(公告)号：US09238658B2
公开(公告)日：2016-01-19
申请号：US14363033
申请日：2012-12-05
发明人： Shyh-Ming Yang , Gee-Hong Kuo , Micheal D. Gaul , Thomas A. Rano
IPC分类号： C07D513/04 , C07D231/56 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D261/20 , C07D487/04 , C07D209/08 , C07D209/34 , C07D401/04 , C07D401/14 , C07D407/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04
CPC分类号： C07D513/04 , C07D209/08 , C07D209/34 , C07D231/56 , C07D261/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D407/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention is directed to novel piperidinyl-carboxamide derivatives, pharmaceutical compositions containing them and their use as inhibitors of SCD1, useful in the treatment of obesity, type-II diabetes and other related metabolic disorders.
摘要翻译： 本发明涉及新颖的哌啶基 - 甲酰胺衍生物，含有它们的药物组合物及其作为SCD1抑制剂的用途，可用于治疗肥胖症，II型糖尿病和其它相关的代谢紊乱。
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5.发明申请公开(公告)号：US20140371220A1
公开(公告)日：2014-12-18
申请号：US14363051
申请日：2012-12-05
发明人： Shyh-Ming Yang , Gee-Hong Kuo , Micheal D. Gaul , Thomas A. Rano
IPC分类号： C07D417/14 , C07D409/14 , C07D413/14 , C07D401/14
CPC分类号： C07D417/14 , C07D401/14 , C07D409/14 , C07D413/14
摘要： The present invention is directed to novel piperidinyl-pyridazinyl derivatives, pharmaceutical compositions containing them and their use as inhibitors of SCD1, useful in the treatment of obesity, type-II diabetes and other related metabolic disorders.
摘要翻译： 本发明涉及新颖的哌啶基 - 哒嗪衍生物，含有它们的药物组合物及其作为SCD1抑制剂的用途，可用于治疗肥胖症，II型糖尿病和其它相关的代谢紊乱。
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6.发明公开公开(公告)号：US20230183233A1
公开(公告)日：2023-06-15
申请号：US17870165
申请日：2022-07-21
发明人： Guozhang Xu , Mark J. Macielag , Micheal D. Gaul , Zhijie Liu
IPC分类号： C07D471/04 , C07D471/10 , C07D487/04
CPC分类号： C07D471/04 , C07D471/10 , C07D487/04
摘要： The present invention is directed to bicyclic pyridinon-2-one and pyrimidin-4-one derivatives, stereoisomers, isotopologues, and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.
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公开(公告)号：US20230097157A1
公开(公告)日：2023-03-30
申请号：US17870156
申请日：2022-07-21
发明人： Guozhang Xu , Mark J. Macielag , Micheal D. Gaul , Tho V. Thieu , Zhijie Liu
IPC分类号： C07D471/04
摘要： The present invention is directed to bicyclic pyridinon-2-one and pyrimidin-4-one derivatives, stereoisomers, isotopologues, and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.
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公开(公告)号：US20220315561A1
公开(公告)日：2022-10-06
申请号：US17696922
申请日：2022-03-17
发明人： Guozhang Xu , Tho V. Thieu , Zhijie Liu , Micheal D. Gaul
IPC分类号： C07D401/14
摘要： The present invention provides imidazole substituted pyridine N-oxide derivatives, stereoisomers, isotopologues, isotopomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.
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9.发明授权Substituted piperidinyl-pyridazinyl derivatives useful as SCD 1 inhibitors 有权用作SCD 1抑制剂的取代的哌啶基 - 哒嗪衍生物公开(公告)号：US09102669B2
公开(公告)日：2015-08-11
申请号：US14363051
申请日：2012-12-05
发明人： Shyh-Ming Yang , Gee-Hong Kuo , Micheal D. Gaul , Thomas A. Rano
IPC分类号： C07D295/00 , C07D417/14 , C07D401/14 , C07D413/14 , C07D409/14
CPC分类号： C07D417/14 , C07D401/14 , C07D409/14 , C07D413/14
摘要： The present invention is directed to novel piperidinyl-pyridazinyl derivatives, pharmaceutical compositions containing them and their use as inhibitors of SCD1, useful in the treatment of obesity, type-II diabetes and other related metabolic disorders.
摘要翻译： 本发明涉及新颖的哌啶基 - 哒嗪衍生物，含有它们的药物组合物及其作为SCD1抑制剂的用途，可用于治疗肥胖症，II型糖尿病和其它相关的代谢紊乱。
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公开(公告)号：US20240228465A1
公开(公告)日：2024-07-11
申请号：US18428046
申请日：2024-01-31
发明人： Guozhang Xu , Tho V. Thieu , Zhijie Liu , Micheal D. Gaul
IPC分类号： C07D401/14
CPC分类号： C07D401/14
摘要： The present invention provides imidazole substituted pyridine N-oxide derivatives, stereoisomers, isotopologues, isotopomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.
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