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公开(公告)号：US12110324B2
公开(公告)日：2024-10-08
申请号：US18356891
申请日：2023-07-21
发明人： Antonios O. Aliprantis , Zachary Kohl Costello , Anthony John Coyle , Kristen Park Hopson , Ryan Terrell Phennicie , Alexis Hiram Ramos , Adam Reid Root , Lana Dinic , Karin Alma Frieda Reif
CPC分类号： C07K16/244 , A61P11/06 , C07K2317/24 , C07K2317/565
摘要： The disclosure provides, in various embodiments, polypeptides (e.g., antibodies and antigen binding fragments thereof) that specifically bind to a thymic stromal lymphopoietin (TSLP) (e.g., a full-length human TSLP). The disclosure also provides, in various embodiments, fusion proteins comprising one or more of the polypeptides, polynucleotides encoding the polypeptides, vectors and host cells suitable for expressing the polypeptides, and methods for treating a TSLP-associated disease or condition.
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公开(公告)号：US20240285798A1
公开(公告)日：2024-08-29
申请号：US18461021
申请日：2023-09-05
申请人： TranscripTx, Inc.
IPC分类号： A61K48/00 , A61K9/127 , A61K31/7105 , A61K31/7115 , A61K47/69 , A61P11/00 , A61P11/06 , C12N15/113
CPC分类号： A61K48/005 , A61K9/1271 , A61K31/7105 , A61K31/7115 , A61K47/6925 , A61K48/0041 , A61P11/00 , A61P11/06 , C12N15/113
摘要： Polynucleotides encoding peptides, proteins, enzymes, and functional fragments thereof are disclosed. The polynucleotides of the disclosure can be effectively delivered to an organ, such as the lung, and expressed within cells of the organ. The polyribonucleotides of the disclosure can be used to treat a disease or condition associated with cilia maintenance and function, impaired function of the axoneme, such as DNAI1 or DNAH5.
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公开(公告)号：US20240261364A1
公开(公告)日：2024-08-08
申请号：US18454013
申请日：2023-08-22
申请人： SERPIN PHARMA, LLC
发明人： Dana AUSTIN , Cohava GELBER
IPC分类号： A61K38/10 , A61P1/00 , A61P11/00 , A61P11/06 , A61P17/00 , A61P25/04 , A61P25/28 , A61P29/00 , A61P31/14 , A61P31/18 , A61P37/08
CPC分类号： A61K38/10 , A61P1/00 , A61P11/00 , A61P11/06 , A61P17/00 , A61P25/04 , A61P25/28 , A61P29/00 , A61P31/14 , A61P31/18 , A61P37/08
摘要： Disclosed herein are SERPIN peptides, and analogues and derivatives thereof, and uses of the same for treating various conditions associated with LRP1 mediation or TSLP-mediation.
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公开(公告)号：US20240261224A1
公开(公告)日：2024-08-08
申请号：US18526352
申请日：2023-12-01
发明人： Frazer Giles Morgan , Rebecca Annabel Louise Greenan , Martin James Oliver , Christopher D. O’Brien
IPC分类号： A61K9/14 , A61K9/00 , A61K9/48 , A61K31/4545 , A61P11/06
CPC分类号： A61K9/145 , A61K9/0075 , A61K9/143 , A61K9/485 , A61K9/4858 , A61K31/4545 , A61P11/06
摘要： The present disclosure relates to formulations comprising (S)-3-(3-(1-methyl-2-oxo-5-(pyrazolo[1,5-a]pyridin-3-yl)-1,2-dihydro-3H-imidazo[4,5-b]pyridin-3-yl)piperidin-1-yl)-3-oxopropanenitrile and methods of preparation.
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公开(公告)号：US20240209102A1
公开(公告)日：2024-06-27
申请号：US18523048
申请日：2023-11-29
IPC分类号： C07K16/28 , A61K38/17 , A61K39/00 , A61K39/395 , A61K45/06 , A61P1/00 , A61P1/04 , A61P9/14 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/08 , C07K14/715 , C07K16/24
CPC分类号： C07K16/2866 , A61K38/1793 , A61K39/3955 , A61K45/06 , A61P1/00 , A61P1/04 , A61P9/14 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/08 , C07K14/7155 , C07K16/244 , A61K2039/507 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2319/00
摘要： The present invention provides methods for treating inflammatory diseases, or conditions associated with, or resulting in part from, elevated levels of IL-33 and IL-4, in particular inflammatory lung disorders. The methods of the present invention comprise administering to a subject in need thereof one or more therapeutically effective doses of an IL-33 antagonist alone or in combination with one or more therapeutically effective doses of an IL-4R antagonist. In certain embodiments, the methods of the present invention include use of the antagonists to treat any inflammatory disease or condition mediated in part by enhanced IL-33-mediated signaling and IL-4-mediated signaling.
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6.发明公开公开(公告)号：US20240190979A1
公开(公告)日：2024-06-13
申请号：US18583713
申请日：2024-02-21
发明人： Chenghai Zhang , Jinlin Guo , Yujing Yuan
IPC分类号： C07K16/28 , A61K39/00 , A61K39/395 , A61P11/06 , C12N5/16
CPC分类号： C07K16/2866 , A61K39/3955 , A61P11/06 , C07K16/2896 , C12N5/16 , A61K39/00 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2510/02
摘要： The present invention discloses an antibody capable of binding to human interleukin 4 receptor alpha (hIL-4R alpha) and a preparation method and application thereof. The anti-hIL-4R alpha antibody can specifically bind to hIL-4R alpha, has good effects for inhibiting IL-4 and IL-13-induced cell line proliferation and the like, and can be applied to treatment of IL-4R alpha related diseases, such as immune-mediated inflammatory diseases.
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公开(公告)号：US20240182479A1
公开(公告)日：2024-06-06
申请号：US18500155
申请日：2023-11-02
申请人： AstraZeneca AB
IPC分类号： C07D487/04 , A61P11/06 , A61P37/06
CPC分类号： C07D487/04 , A61P11/06 , A61P37/06
摘要： The present application relates to chemical compounds of Formula (I), and pharmaceutically acceptable salts thereof, that inhibit IRAK4 and consequently have potential utility in medicine.
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公开(公告)号：US20240173342A1
公开(公告)日：2024-05-30
申请号：US17549584
申请日：2021-12-13
IPC分类号： A61K31/7032 , A61K9/00 , A61P11/06 , A61P39/00
CPC分类号： A61K31/7032 , A61K9/0053 , A61P11/06 , A61P39/00
摘要： The invention provides compositions and methods for treating asthma in a subject in need thereof comprising administering chemically synthesized secoisolaricirecinol diglucoside (SDG), and in particular, a racemic mixture of the SDG (LGM2605), stereoisomers thereof, metabolites thereof, and analogs thereof. Also provided are methods for treating or preventing ozone-induced damage in a subject in need thereof.
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公开(公告)号：US20240141026A1
公开(公告)日：2024-05-02
申请号：US18548850
申请日：2022-03-04
CPC分类号： C07K16/18 , A61P11/06 , A61P29/00 , A61K2039/505 , C07K2317/24 , C07K2317/92
摘要： The present invention is based on the surprising finding that the MPC5B4 anti-periostin monoclonal antibody can effectively prevent and treat inflammation, fibrosis and worsening of pulmonary inflammation and respiratory diseases in various animal models. The MPC5B4 anti-periostin monoclonal antibody recognizes specifically the peptide sequence of SEQ ID NO:1, corresponding to the amino acid sequence 136-151 located within the fasciclin (FAS)1-1 domain of the periostin protein (POSTN), inhibiting its binding to the αvβ3 integrin.
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公开(公告)号：US20240139158A1
公开(公告)日：2024-05-02
申请号：US18542018
申请日：2023-12-15
发明人： John Miller , Cecilia M. Bastos , Benito Munoz
IPC分类号： A61K31/422 , A61K9/00 , A61K31/341 , A61K31/404 , A61K31/4192 , A61K31/4245 , A61K31/433 , A61K31/443 , A61K31/454 , A61K31/47 , A61K31/5377 , A61K31/7036 , A61K45/06 , A61P11/06 , A61P11/08
CPC分类号： A61K31/422 , A61K9/0053 , A61K9/0073 , A61K31/341 , A61K31/404 , A61K31/4192 , A61K31/4245 , A61K31/433 , A61K31/443 , A61K31/454 , A61K31/47 , A61K31/5377 , A61K31/7036 , A61K45/06 , A61P11/06 , A61P11/08 , A61K31/191
摘要： The present disclosure features disclosed method of treating disorders such as COPD, bronchitis and/or asthma using disclosed compounds, optionally together with one or more additional active agents. Contemplated methods include administrating orally or by inhalation to a patient one or more disclosed compounds.
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