公开(公告)号：US12070469B2

公开(公告)日：2024-08-27

申请号：US17192609

申请日：2021-03-04

申请人： SANIFIT THERAPEUTICS S.A.

发明人： Joan Perello Bestard ,  Carolina Salcedo Roca ,  Ana-Zeralda Canals Hamann

IPC分类号： A61K31/7024 ,  A61K9/00 ,  A61K31/661 ,  A61K31/6615 ,  A61K31/7032 ,  A61P9/00 ,  A61P17/02 ,  A61P19/08

CPC分类号： A61K31/7024 ,  A61K9/0014 ,  A61K9/0019 ,  A61K31/6615 ,  A61K31/7032 ,  A61P9/00 ,  A61P17/02 ,  A61P19/08

摘要： The present disclosure related to compositions, methods, dosages, dosage regimens, articles of manufacture and kits for the treatment and/or prevention ectopic calcifications, and in particular cutaneous calcifications such as calciphylaxis calcifications comprising inositol phosphate, inositol phosphate analogs, inositol phosphate derivatives, or combinations thereof. In a particular aspect the disclosure provides a dosage regimen to treat calciphylaxis comprising the administration of 6 mg/kg to 9 mg/kg daily doses of myo-inositol hexaphosphate, three times a week, for at least 1 to 8 months.

公开(公告)号：US12048725B2

公开(公告)日：2024-07-30

申请号：US18495757

申请日：2023-10-27

申请人： TCI CO., LTD.

发明人： Yung-Hsiang Lin ,  Chu-Han Huang

IPC分类号： A61K36/87 ,  A61K31/702 ,  A61K31/7032 ,  A61K31/733 ,  A61P1/14

CPC分类号： A61K36/87 ,  A61K31/702 ,  A61K31/7032 ,  A61K31/733 ,  A61P1/14 ,  A61K2236/19

摘要： Methods for promoting intestinal health of a subject in need thereof and for enhancing antioxidation in a subject in a subject in need thereof are provided. The methods include administering to the subject a prebiotic composition, which includes grape ferment, lactitol, and fructooligosaccharide. The weight ratio of the grape ferment, the lactitol, and the fructooligosaccharide falls within the range of 1-2:1-2:1-2. The grape ferment is obtained by fermenting grape extract with Saccharomyces cerevisiae and Streptococcus thermophilus.

公开(公告)号：US20240189327A1

公开(公告)日：2024-06-13

申请号：US18279974

申请日：2022-03-03

申请人： LONDON PHARMACEUTICALS AND RESEARCH CORPORATION

发明人： Mahmoud Mohamed Abdrabo Moustafa

IPC分类号： A61K31/00 ,  A61K9/06 ,  A61K9/20 ,  A61K9/48 ,  A61K9/50 ,  A61K31/7032 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26

CPC分类号： A61K31/658 ,  A61K9/06 ,  A61K9/2009 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/4858 ,  A61K9/4866 ,  A61K9/50 ,  A61K31/7032 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26

摘要： Cannabinoid esters and their soluble salts with synergistic or additive therapeutic counterparts and stable formulations thereof, as well as their edible, beverage and medicinal applications. The synergistic or additive cannabinoid esters may be used as drugs or prodrugs for treating various conditions related to the modulation or biased modulation of cannabinoid receptors, including but not limited to, pain and inflammation, arthritis, cancer, glaucoma, neurodegenerative disorders, multiple sclerosis, renal fibrosis, fibrotic disorder, mental health disorders, addiction, motor function disorders and gastrointestinal and metabolic disorders.

公开(公告)号：US20240173371A1

公开(公告)日：2024-05-30

申请号：US18515601

申请日：2023-11-21

申请人： NutriScience Innovations LLC

发明人： Michael Lelah ,  David Bom

IPC分类号： A61K36/41 ,  A61K31/7032

CPC分类号： A61K36/41 ,  A61K31/7032 ,  A61K2236/333 ,  A61K2236/51

摘要： The present disclosure relates generally to dietary supplements and compositions containing Rhodiola crenulata administered in therapeutically effective amounts for effecting health in a mammal. Disclosed are compositions containing an improved extract of Rhodiola crenulata containing a higher content level of salidrosides (>5%), and a reduced number of or absence of other flavonoids. In this manner, the resulting novel composition has enhanced bioactivity of salidroside, and therefore, improved treatment and health benefit possibilities.

公开(公告)号：US20240165138A1

公开(公告)日：2024-05-23

申请号：US18548997

申请日：2022-02-18

申请人： TOYOBO CO., LTD.

发明人： Akio KAWAHARA ,  Shuhei YAMAMOTO

IPC分类号： A61K31/7032 ,  A61K8/60 ,  A61P31/16 ,  A61Q17/00 ,  A61Q19/10

CPC分类号： A61K31/7032 ,  A61K8/602 ,  A61P31/16 ,  A61Q17/005 ,  A61Q19/10 ,  A61K2800/74

摘要： Provided is an antiviral agent that is suitable not only for application in articles but also for application in living organisms, and that is safer for living organisms. The antiviral agent contains mannosylerythritol lipids (MELs) as an active ingredient, preferably in an amount of 0.000001 to 100 wt %, and is applicable to living organisms and/or articles.

公开(公告)号：US20230414692A1

公开(公告)日：2023-12-28

申请号：US18248915

申请日：2021-10-11

申请人： UNIVERSIDAD DE GRANADA ,  CELLBITEC, S.L.

发明人： Francisco BERMÚDEZ PÉREZ ,  Jose Carlos PRADOS SALAZAR ,  Consolación MELGUIZO ALONSO ,  Jesús Mª PORRES FOULQUIE ,  Cristina MESAS HERNÁNDEZ ,  Rosario MARTÍNEZ MARTÍNEZ ,  Milagros GALISTEO MOYA ,  Raúl ORTIZ QUESADA ,  Laura CABEZA MONTILLA ,  María LÓPEZ-JURADO ROMERO DE LA CRUZ

IPC分类号： A61K36/81 ,  A61K45/06 ,  A61K31/343 ,  A61K31/7028 ,  A61K31/7048 ,  A61K31/7032 ,  A61P35/00

CPC分类号： A61K36/81 ,  A61K45/06 ,  A61K31/343 ,  A61K31/7028 ,  A61K31/7048 ,  A61K31/7032 ,  A61P35/00 ,  A61K2236/15 ,  A61K2236/333 ,  A61K2236/53 ,  A61K2236/39

摘要： The present invention provides a method for obtaining an ethanolic extract from mature seeds of Solanum melongena, preferably defatted, characterized in that they are extracted with a hydroalcoholic solution containing 50% ethanol, at acid PH, preferably under a nitrogen atmosphere and for short periods of time, no longer than 1-2 h. The extracts obtained from different varieties of Solanum melongena have a high polyphenol content and show potent antitumor activity against colon adenocarcinoma, pancreatic adenocarcinoma and glioblastoma multiforme cell lines, even against chemotherapy-resistant lines, but with low toxicity to human hepatocytes. Therefore, the extracts of the invention are proposed for use in the treatment of colon adenocarcinoma, pancreatic adenocarcinoma and glioblastoma multiforme, including those resistant to currently used chemotherapies.

公开(公告)号：US11730778B2

公开(公告)日：2023-08-22

申请号：US17028490

申请日：2020-09-22

申请人： ACCESS BUSINESS GROUP INTERNATIONAL LLC

发明人： Brandon C. Iker ,  Matthew K. Runyon

IPC分类号： A61K35/747 ,  A61K31/7048 ,  A61K35/745 ,  A61P3/02 ,  A61K31/7032 ,  A61K31/352 ,  A61K31/353

CPC分类号： A61K35/747 ,  A61K31/352 ,  A61K31/353 ,  A61K31/7032 ,  A61K31/7048 ,  A61K35/745 ,  A61P3/02

摘要： A method useful for providing a phytonutrient to a subject via mediation of the subject's microbiome is disclosed. The method includes administering a phytofunctional composition to a subject change the phytonutrient producer status of the subject. The method may also include identifying a phytonutrient producer status of the subject by assessing a level of at least one of a preselected phytonutrient and a preselected phytonutrient precursor compound within the subject. A phytofunctional composition useful in the method is also disclosed, and comprises a phytonutrient precursor compound and an active agent. The active agent comprises a probiotic and/or a prebiotic, and is adapted to mediate production of the preselected phytonutrient in the gastrointestinal tract of the subject, thereby changing the phytonutrient producer status of the subject.

公开(公告)号：US11608353B2

公开(公告)日：2023-03-21

申请号：US16675535

申请日：2019-11-06

申请人： THE UNIVERSITY OF BRITISH COLUMBIA

发明人： Stephen G. Withers ,  Gary D. Brayer ,  Leslie Karen Williams ,  Xiaohua Zhang

IPC分类号： A61K31/7034 ,  A61K31/7048 ,  A61K31/7032 ,  C07H15/26 ,  C07C33/26 ,  C07D311/30 ,  C07H15/203 ,  A23G4/12 ,  A23L33/105 ,  C07H1/06

摘要： There are provided compounds of Formula I: various compositions thereof and methods for their use in the inhibition of α-amylase.

公开(公告)号：US20230071924A1

公开(公告)日：2023-03-09

申请号：US17818591

申请日：2022-08-09

申请人： GINA SLOAN

发明人： GINA SLOAN

IPC分类号： A61K35/745 ,  A61K35/747 ,  A61K38/47 ,  A61K38/46 ,  A61K31/717 ,  A61K31/719 ,  A61K31/7016 ,  A61K31/715 ,  A61K31/7032 ,  A61K47/14 ,  A61K47/12 ,  A61K47/18 ,  A61K47/24 ,  A61P1/14 ,  A61K9/00 ,  A61P31/04 ,  A23K10/18 ,  A23K20/189 ,  A23K50/75

摘要： A probiotic composition comprised of a probiotic, a prebiotic, a complex-starch reducing enzyme, an enzymatic co-factor, and a pH modifier. The probiotic composition facilitates the creation of a biofilm within the GI tract of poultry that outcompetes and excludes pathogens. The probiotic composition can be incorporated into an eggwash and sprayed onto an egg, the sprayed egg developing a stable probiotic population within the GI tract of the pre-hatched chick. The probiotic composition can also be incorporated into poultry feed by applying the probiotic composition as a mash prior to pelleting. The probiotic composition can also be applied post-pelleting as a wet or dry spray, directly onto the pellets. In some instances, the probiotic composition can be added a drinking water source used by poultry as a water additive. Poultry that consume feed or water that contain the probiotic composition develop a stable probiotic population within their GI tracts.

公开(公告)号：US20220395520A1

公开(公告)日：2022-12-15

申请号：US17821282

申请日：2022-08-22

申请人： GLYCOM A/S

发明人： Nikolay KHANZHIN ,  Markus JONDELIUS HEDEROS ,  Louise Kristine VIGSNÆS ,  Bruce MCCONNELL

IPC分类号： A61K31/702 ,  C12P19/04 ,  C12P1/04 ,  C12N9/10 ,  A61K31/716 ,  A61P31/04 ,  A61K31/7016 ,  A61K31/7032 ,  C07H1/00

摘要： A mixture of human milk oligosaccharides that comprises or consists essentially of a) LNTri II, LNT, pLNH II and optionally lactose, or b) LNTri II, LNnT, pLNnH and optionally lactose, and is useful for preventing or treating viral or bacterial, intestinal and respiratory infections and for modulating the human gastrointestinal microbiota to increase Bifidobacterium abundance. A process for preparing the mixture and methods of crystallizing LNnT and LNT is also described.