公开(公告)号：US11344587B2

公开(公告)日：2022-05-31

申请号：US16692265

申请日：2019-11-22

申请人： TCI CO., LTD.

发明人： Yung-Hsiang Lin ,  Chu-Han Huang ,  Cheng-Yu Ho

IPC分类号： A61K35/747 ,  A61P31/10 ,  A61P31/04 ,  A61P13/02

摘要： Provided is a method of improving urogenital health, including administering to a subject a composition including an effective amount of a Lactobacillus johnsonii strain deposited under the accession number of DSM 33288 or a metabolite thereof. The Lactobacillus johnsonii strain, which is a probiotic, and metabolites thereof inhibit the growth of common pathogenic bacteria and fungi causing genitourinary tract infections, thereby reducing the risk of genitourinary tract infections or alleviating symptoms thereof. Also provided is a composition for improving urogenital health which includes the Lactobacillus johnsonii strain.

公开(公告)号：US20210000893A1

公开(公告)日：2021-01-07

申请号：US16693758

申请日：2019-11-25

申请人： TCI CO., LTD.

发明人： Yung-Hsiang Lin ,  Chu-Han Huang ,  Cheng-Yu Ho

IPC分类号： A61K35/747 ,  C12R1/25 ,  A61P19/06

摘要： The present disclosure provides a Lactobacillus plantarum strain and a method for regulating expression of IL-1β gene, TNF-α gene, MMP1α gene and TIMP1 gene, and treating gout using the Lactobacillus plantarum strain.

公开(公告)号：US12048725B2

公开(公告)日：2024-07-30

申请号：US18495757

申请日：2023-10-27

申请人： TCI CO., LTD.

发明人： Yung-Hsiang Lin ,  Chu-Han Huang

IPC分类号： A61K36/87 ,  A61K31/702 ,  A61K31/7032 ,  A61K31/733 ,  A61P1/14

CPC分类号： A61K36/87 ,  A61K31/702 ,  A61K31/7032 ,  A61K31/733 ,  A61P1/14 ,  A61K2236/19

摘要： Methods for promoting intestinal health of a subject in need thereof and for enhancing antioxidation in a subject in a subject in need thereof are provided. The methods include administering to the subject a prebiotic composition, which includes grape ferment, lactitol, and fructooligosaccharide. The weight ratio of the grape ferment, the lactitol, and the fructooligosaccharide falls within the range of 1-2:1-2:1-2. The grape ferment is obtained by fermenting grape extract with Saccharomyces cerevisiae and Streptococcus thermophilus.

公开(公告)号：US20200306324A1

公开(公告)日：2020-10-01

申请号：US16731305

申请日：2019-12-31

申请人： TCI CO., LTD.

发明人： Yung-Hsiang Lin ,  Chu-Han Huang ,  Cheng-Yu Ho

IPC分类号： A61K35/747 ,  A23L33/135

摘要： The present invention provides a method of reducing body fat, comprising administering a composition comprising an effective amount of Lactobacillus paracasei or a metabolite thereof to a subject in need thereof. The Lactobacillus paracasei or the metabolite thereof can effectively convert the fatty acid into conjugated linoleic acid, inhibit the accumulation of fat and promote the decomposition of fat in fat cells, and can effectively reduce the percentage of body fat, waist circumference, and hip circumference, and simultaneously increase the muscle mass of the subject.

公开(公告)号：US20220088095A1

公开(公告)日：2022-03-24

申请号：US17543752

申请日：2021-12-07

申请人： TCI CO., LTD.

发明人： YUNG-HSIANG LIN ,  Chu-Han Huang ,  Cheng-Yu Ho

IPC分类号： A61K35/747 ,  A61P19/06 ,  C12N1/20

摘要： The present disclosure provides a method for regulating expression of IL-1β gene, MMP1a gene and TIMP1 gene of chondrocytes using a Lactobacillus plantarum strain TCI227.

公开(公告)号：US11202812B2

公开(公告)日：2021-12-21

申请号：US16731305

申请日：2019-12-31

申请人： TCI CO., LTD.

发明人： Yung-Hsiang Lin ,  Chu-Han Huang ,  Cheng-Yu Ho

IPC分类号： A61K35/747 ,  A23L33/135 ,  A61P3/04

摘要： The present invention provides a method of reducing body fat, comprising administering a composition comprising an effective amount of Lactobacillus paracasei or a metabolite thereof to a subject in need thereof. The Lactobacillus paracasei or the metabolite thereof can effectively convert the fatty acid into conjugated linoleic acid, inhibit the accumulation of fat and promote the decomposition of fat in fat cells, and can effectively reduce the percentage of body fat, waist circumference, and hip circumference, and simultaneously increase the muscle mass of the subject.

公开(公告)号：US20210023159A1

公开(公告)日：2021-01-28

申请号：US16727389

申请日：2019-12-26

申请人： TCI CO., LTD.

发明人： Yung-Hsiang Lin ,  Chu-Han Huang ,  Cheng-Yu Ho

IPC分类号： A61K36/88 ,  C12N1/20 ,  A61P3/06 ,  A61K31/702

摘要： Provided is a method of promoting the growth of Akkermansia muciniphila, including contacting A. muciniphila with an effective amount of a prebiotic composition including a Musa ferment. Also provided is a prebiotic composition including a Musa ferment. The prebiotic composition promotes the growth of A. muciniphila in the intestine, and reduces the body weight, fat percentage, waist circumference, and hip circumference of obese individuals.

公开(公告)号：US11712413B2

公开(公告)日：2023-08-01

申请号：US16932867

申请日：2020-07-20

申请人： TCI CO., LTD.

发明人： Chu-Han Huang ,  Yung-Hsiang Lin

IPC分类号： A61Q19/00 ,  A61Q19/08 ,  A23L33/135 ,  A61K35/747 ,  A61P17/00 ,  C12N1/20 ,  A61K8/99

CPC分类号： A61K8/99 ,  A61Q19/007

摘要： A Halobacillus trueperi TCI66207 strain, deposited in the Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures (Accession number DSM 33381). The H. trueperi TCI66207 strain has one or more of the following function: improving skin cell mitochondrion activity, promoting skin cell proliferation, maintaining skin corneum layer completeness, increasing expression of keratin (Keratin14) and/or hyaluronic acid synthase (HAS3) genes and promoting hyaluronic acid production.

公开(公告)号：US11478525B2

公开(公告)日：2022-10-25

申请号：US16727389

申请日：2019-12-26

申请人： TCI CO., LTD.

发明人： Yung-Hsiang Lin ,  Chu-Han Huang ,  Cheng-Yu Ho

IPC分类号： A61K36/88 ,  A61K31/702 ,  A61P3/06 ,  C12N1/20

摘要： Provided is a method of promoting the growth of Akkermansia muciniphila, including contacting A. muciniphila with an effective amount of a prebiotic composition including a Musa ferment. Also provided is a prebiotic composition including a Musa ferment. The prebiotic composition promotes the growth of A. muciniphila in the intestine, and reduces the body weight, fat percentage, waist circumference, and hip circumference of obese individuals.

公开(公告)号：US11938157B2

公开(公告)日：2024-03-26

申请号：US17812182

申请日：2022-07-13

申请人： TCI CO., LTD.

发明人： Yung-Hsiang Lin ,  Chu-Han Huang

IPC分类号： A61K35/747 ,  A61K8/9789 ,  A61K36/746 ,  A61P3/04 ,  A61P17/16 ,  A61P17/18 ,  A61P19/08 ,  A61Q19/00 ,  C12N1/20 ,  C12N9/16 ,  C12R1/225

CPC分类号： A61K35/747 ,  A61P19/08 ,  C12N1/205 ,  C12N9/16 ,  C12R2001/225

摘要： Provided is Lactobacillus paracasei TCI727, deposited in the Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSMZ) with a deposit number of DSM 33756. A method for improving calcium absorption of a subject in need thereof by using the Lactobacillus paracasei TCI727 or metabolites thereof is also provided. The method includes administering to the subject an effective amount of a composition comprising the Lactobacillus paracasei TCI727 or the metabolites thereof.