公开(公告)号：US20240182479A1

公开(公告)日：2024-06-06

申请号：US18500155

申请日：2023-11-02

Applicant: AstraZeneca AB

Inventor： Ina TERSTIEGE ,  Stefan SCHIESSER ,  Yafeng XUE ,  Hui-Fang CHANG ,  Anna Ingrid Kristina BERGGREN

IPC: C07D487/04 ,  A61P11/06 ,  A61P37/06

CPC classification number: C07D487/04 ,  A61P11/06 ,  A61P37/06

Abstract: The present application relates to chemical compounds of Formula (I), and pharmaceutically acceptable salts thereof, that inhibit IRAK4 and consequently have potential utility in medicine.

公开(公告)号：US20240374588A1

公开(公告)日：2024-11-14

申请号：US18625479

申请日：2024-04-03

Applicant: AstraZeneca AB

Inventor： Ina TERSTIEGE ,  Aaron Thomas GARRISON ,  John Joseph MURPHY ,  Karolina KWAPIEN

IPC: A61K31/5025 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/513 ,  C07D401/14 ,  C07D487/04

Abstract: This specification relates to compounds according to Formula (I), which are of PROTACs of IRAK4, to pharmaceutical compositions containing them, and to their use in therapy for the treatment of IRAK4-mediated and/or IRAK-4 directed diseases and disorders.

公开(公告)号：US20240300923A1

公开(公告)日：2024-09-12

申请号：US18612156

申请日：2024-03-21

Applicant: ASTRAZENECA AB

Inventor： Ina TERSTIEGE ,  Stefan SCHIESSER

IPC: C07D401/14 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/501 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14

CPC classification number: C07D401/14 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/501 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14

Abstract: The present application relates to chemical compounds of Formula (1), and pharmaceutically acceptable salts thereof, that inhibit IRAK4 and consequently have potential utility in medicine.

公开(公告)号：US20220185817A1

公开(公告)日：2022-06-16

申请号：US17457249

申请日：2021-12-01

Applicant: AstraZeneca AB

Inventor： Ina TERSTIEGE ,  Stefan SCHIESSER ,  Yafeng XUE ,  Hui-Fang CHANG ,  Anna Ingrid Kristina BERGGREN

IPC: C07D487/04 ,  A61P11/06 ,  A61P37/06

Abstract: The present application relates to chemical compounds of Formula (I), and pharmaceutically acceptable salts thereof, that inhibit IRAK4 and consequently have potential utility in medicine.