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公开(公告)号：US20240359010A1
公开(公告)日：2024-10-31
申请号：US18763996
申请日：2024-07-03
发明人： Daniel Kacy Cullen , James P. Harris , John A. Wolf , Han-Chiao Isaac Chen , Douglas H. Smith , Mijail Serruya
CPC分类号： A61N1/36067 , A61B5/293 , A61B5/6868 , A61N1/05 , A61N1/0536 , A61N1/36182 , A61N5/0601 , A61N5/0622 , A61B5/0059 , A61B5/01 , A61B5/4082 , A61B5/4088 , A61B5/4094 , A61N1/0531
摘要： In one aspect, the invention comprises an implantable living electrode comprising a substantially cylindrical extracellular matrix core; one or more neurons implanted along or within the substantially cylindrical extracellular matrix core, the one or more neurons including one or more optogenetic or magnetogenetic neurons proximal to a first end of the implantable living electrode.
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2.发明公开公开(公告)号：US20240358821A1
公开(公告)日：2024-10-31
申请号：US18577550
申请日：2022-07-06
CPC分类号： A61K39/29 , A61K9/127 , A61K9/5123 , A61P31/14 , C12N7/00 , A61K2039/53 , A61K2039/55555 , C12N2770/24222 , C12N2770/24234
摘要： Described are compositions comprising a nucleoside-modified RNA molecules encoding a HCV p7 protein in combination with at least one additional HCV antigen, adjuvant, or a combination thereof, and their use for inducing an immune response against HCV.
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公开(公告)号：US20240343783A1
公开(公告)日：2024-10-17
申请号：US18420525
申请日：2024-01-23
发明人： Michael C. Milone , Enxiu Wang
IPC分类号： C07K16/18 , C07K14/705 , C07K14/735
CPC分类号： C07K16/18 , C07K14/70503 , C07K14/70535 , C07K2319/03 , C07K2319/33 , C07K2319/70
摘要： The present invention provides compositions and methods for regulating the specificity and activity of T cells. In one embodiment, the invention provides a type of chimeric antigen receptor (CAR) wherein the CAR is termed a “KIR-CAR” which is a CAR design comprising a component of a receptor naturally found on natural killer (NK) cells. In one embodiment, the NK receptor includes but is not limited to a naturally occurring activating and inhibitory receptor of NK cells known as a killer cell immunoglobulin-like receptor (KIR).
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4.发明公开公开(公告)号：US20240335539A1
公开(公告)日：2024-10-10
申请号：US18682232
申请日：2022-08-10
发明人： Marco Ruella , Yong Gu Lee
CPC分类号： A61K39/464412 , A61K39/4631 , A61K39/4637 , A61P35/00 , C07K14/4747 , C07K14/7051 , C07K16/2803 , C12N15/86 , C07K2317/622 , C07K2319/02 , C07K2319/30 , C12N2740/15043
摘要： The present disclosure provides modified cell(s), i.e., immune cell(s) or precursor cell(s) thereof, wherein the cell(s) are engineered to express a) a chimeric antigen receptor (CAR), and b) a variant of a B-cell lymphoma 2 (Bcl-2) family protein, wherein the variant confers resistance to a cytotoxic inhibitor of the Bcl-2 family protein. Also provided are methods and uses of the modified cells, e.g., for treating at least one sign and/or symptom of cancer. Related nucleic acids, vectors, and pharmaceutical compositions are also provided.
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5.发明公开公开(公告)号：US20240325535A1
公开(公告)日：2024-10-03
申请号：US18708529
申请日：2022-11-10
IPC分类号： A61K39/00 , A61P35/00 , C07K14/705 , C07K14/725 , C07K16/30
CPC分类号： A61K39/4644 , A61K39/4611 , A61K39/4631 , A61P35/00 , C07K14/70503 , C07K14/7051 , C07K14/70521 , C07K14/70532 , C07K14/70578 , C07K14/70596 , C07K16/30 , C07K2319/03
摘要： The present disclosure provides modified immune cells or precursors thereof (e.g., gene edited modified T cells) comprising a chimeric antigen receptor (CAR) and wherein PRDM1 and/or NR4A3 and/or PRDM1 are knocked-out. Compositions and methods of treatment are also provided.
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公开(公告)号：US12097500B2
公开(公告)日：2024-09-24
申请号：US16852113
申请日：2020-04-17
发明人： Pengfei Xie , Mehdi Javanmard , Mark George Allen , Wen Shen , Naixin Song
CPC分类号： B01L3/5085 , G01N27/02 , G01N33/6863 , B01L2300/0636 , B01L2300/0645 , B01L2300/0893 , B01L2300/123
摘要： A sensor for detecting a target analyte in a sample includes a pair of conducting electrodes that are separated by a gap. An insulator is disposed in the gap between the electrodes. Plural wells are defined by one of the electrodes and the insulator, to expose the other of the electrodes. The wells are configured to receive a sample including a target analyte. The target analyte, when present in the sample received in the wells, modulates an impedance between the electrodes. The modulated impedance, which is measurable with an applied electrical voltage, is indicative of the concentration of the target analyte in the sample. The wells can include antibodies immobilized inside the wells, to bind the target analyte, which can be a cytokine. Also provided are a method for label-free sensing of a target analyte in a sample, and a transcutaneous impedance sensor for label-free, in-situ biomarker detection.
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公开(公告)号：US12097267B2
公开(公告)日：2024-09-24
申请号：US17099421
申请日：2020-11-16
发明人： Jeannette Bennicelli , Jean Bennett , Junwei Sun
CPC分类号： A61K48/005 , A61K38/44 , A61K48/00 , A61K48/0075 , A61P27/02 , C12N9/0036 , C12N9/0051 , C12N15/86 , C12N2750/14143 , C12N2800/22 , C12N2830/001
摘要： Codon optimized nucleic acid sequences for the long form and short form of RdCVF are provided, as well as recombinant viral vectors, such as AAV, expression cassettes, proviral plasmids or other plasmids containing the codon optimized sequences. Recombinant vectors are provided that express the codon optimized RdCVFL and RdCVF individually, or express two copies of a codon optimized RdCVF or RdCVFL nucleic acid sequence, or both RdCVFL and RdCVF in a single vector or virus. Compositions containing these codon optimized sequences are useful in methods for treating, retarding or halting certain blinding diseases resulting from the absence or inappropriate expression of RdCVF and RdCVFL.
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8.发明公开公开(公告)号：US20240307527A1
公开(公告)日：2024-09-19
申请号：US18659530
申请日：2024-05-09
发明人： David B. Weiner , Matthew Morrow
IPC分类号： A61K39/285 , A61K38/20 , C07K14/54 , C12N7/00
CPC分类号： A61K39/285 , A61K38/20 , C07K14/54 , C12N7/00 , Y02A50/30
摘要： Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes IL-28 or a functional fragment thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.
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公开(公告)号：US12082845B2
公开(公告)日：2024-09-10
申请号：US18162036
申请日：2023-01-31
申请人： The Trustees of the University of Pennsylvania , The Children's Hospital of Philadelphia , Onocor LLC
CPC分类号： A61B17/50 , A61B17/22031 , A61B17/221 , A61F2/962 , A61B2017/00367 , A61B2017/00778 , A61B2017/22034 , A61B2017/22035 , A61B2017/2215 , A61F2/2427 , A61F2002/9528 , A61F2002/9623
摘要： Disclosed are systems, methods, and devices for percutaneous retrieval of objects, such as endovascular devices, from an internal body space. The present inventions have vascular, non-vascular (gastrointestinal), and surgical (laproscopic) applications. The inventions include a a wire woven distal end that is formed from wires and includes a substantially cylindrical main body section comprising a leading end, a trailing end, and a middle portion extending between the leading end and the trailing end and defining a longitudinal axis of the main body section, and a flare defining a mouth of the wire woven distal end that projects circumferentially from the leading end of the main body section, wherein when at least a portion of the retrieval end is transitioned to a compressed state following capture of an object, the retrieval end exerts an inward force that at least partially collapses or compresses the object.
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10.发明公开公开(公告)号：US20240285757A1
公开(公告)日：2024-08-29
申请号：US18292247
申请日：2022-08-05
IPC分类号： A61K39/00 , A61P35/00 , C07K16/28 , C12N5/0783 , C12N9/24
CPC分类号： A61K39/4611 , A61K39/4631 , A61K39/4637 , A61K39/464404 , A61P35/00 , C07K16/2863 , C12N5/0636 , C12N9/2402 , C12Y302/01018 , A61K2239/39 , C07K2319/03 , C12N2510/00
摘要： The present invention provides compositions and methods comprising CAR T cells that secrete neuraminidase (e.g., C. perfringens neuraminidase (CpNA)). Compositions and methods of treatment are also provided.
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