专利检索 ap:("THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA") AND inv:"Naomi Balzer-Haas" 第 1 页

1.

发明公开
COMPOSITIONS AND METHODS COMPRISING CAR T CELLS COMPRISING PRDM1 AND/OR NR4A3 KNOCKOUT 审中-公开

公开(公告)号：US20240325535A1

公开(公告)日：2024-10-03

申请号：US18708529

申请日：2022-11-10

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： Joseph A. Fraietta , Inyoung Jung , Naomi Balzer-Haas , Vivek Narayan

IPC分类号： A61K39/00 , A61P35/00 , C07K14/705 , C07K14/725 , C07K16/30

CPC分类号： A61K39/4644 , A61K39/4611 , A61K39/4631 , A61P35/00 , C07K14/70503 , C07K14/7051 , C07K14/70521 , C07K14/70532 , C07K14/70578 , C07K14/70596 , C07K16/30 , C07K2319/03

摘要： The present disclosure provides modified immune cells or precursors thereof (e.g., gene edited modified T cells) comprising a chimeric antigen receptor (CAR) and wherein PRDM1 and/or NR4A3 and/or PRDM1 are knocked-out. Compositions and methods of treatment are also provided.