公开(公告)号：US20240034780A1

公开(公告)日：2024-02-01

申请号：US18356891

申请日：2023-07-21

申请人： Flagship Pioneering Innovations VI, LLC

发明人： Antonios O. Aliprantis ,  Zachary Kohl Costello ,  Anthony John Coyle ,  Kristen Park Hopson ,  Ryan Terrell Phennicie ,  Alexis Hiram Ramos ,  Adam Reid Root ,  Lana Dinic ,  Karin Alma Frieda Reif

IPC分类号： C07K16/24 ,  A61P11/06

CPC分类号： C07K16/244 ,  A61P11/06 ,  C07K2317/565 ,  C07K2317/24

摘要： The disclosure provides, in various embodiments, polypeptides (e.g., antibodies and antigen binding fragments thereof) that specifically bind to a thymic stromal lymphopoietin (TSLP) (e.g., a full-length human TSLP). The disclosure also provides, in various embodiments, fusion proteins comprising one or more of the polypeptides, polynucleotides encoding the polypeptides, vectors and host cells suitable for expressing the polypeptides, and methods for treating a TSLP-associated disease or condition.

公开(公告)号：US12110324B2

公开(公告)日：2024-10-08

申请号：US18356891

申请日：2023-07-21

申请人： Flagship Pioneering Innovations VI, LLC

发明人： Antonios O. Aliprantis ,  Zachary Kohl Costello ,  Anthony John Coyle ,  Kristen Park Hopson ,  Ryan Terrell Phennicie ,  Alexis Hiram Ramos ,  Adam Reid Root ,  Lana Dinic ,  Karin Alma Frieda Reif

IPC分类号： C07K16/24 ,  A61P11/06

CPC分类号： C07K16/244 ,  A61P11/06 ,  C07K2317/24 ,  C07K2317/565

摘要： The disclosure provides, in various embodiments, polypeptides (e.g., antibodies and antigen binding fragments thereof) that specifically bind to a thymic stromal lymphopoietin (TSLP) (e.g., a full-length human TSLP). The disclosure also provides, in various embodiments, fusion proteins comprising one or more of the polypeptides, polynucleotides encoding the polypeptides, vectors and host cells suitable for expressing the polypeptides, and methods for treating a TSLP-associated disease or condition.