发明公开
- 专利标题： USE OF A PERIOSTIN ANTIBODY FOR TREATING INFLAMMATION, FIBROSIS AND LUNG DISEASES
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申请号： US18548850申请日： 2022-03-04
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公开(公告)号： US20240141026A1公开(公告)日： 2024-05-02
- 发明人: Magdiel PEREZ-CRUZ , Bernhard RYFFEL
- 申请人： Centre National de la Recherche Scientifique , Université d'Orléans
- 申请人地址： FR PARIS
- 专利权人： Centre National de la Recherche Scientifique,Université d'Orléans
- 当前专利权人： Centre National de la Recherche Scientifique,Université d'Orléans
- 当前专利权人地址： FR PARIS
- 优先权： EP 305260.8 2021.03.04
- 国际申请： PCT/EP2022/055605 2022.03.04
- 进入国家日期： 2023-09-01
- 主分类号： C07K16/18
- IPC分类号： C07K16/18 ; A61P11/06 ; A61P29/00 ; A61K39/00
摘要：
The present invention is based on the surprising finding that the MPC5B4 anti-periostin monoclonal antibody can effectively prevent and treat inflammation, fibrosis and worsening of pulmonary inflammation and respiratory diseases in various animal models. The MPC5B4 anti-periostin monoclonal antibody recognizes specifically the peptide sequence of SEQ ID NO:1, corresponding to the amino acid sequence 136-151 located within the fasciclin (FAS)1-1 domain of the periostin protein (POSTN), inhibiting its binding to the αvβ3 integrin.
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