公开(公告)号：US20190112321A1

公开(公告)日：2019-04-18

申请号：US16088695

申请日：2017-03-30

Applicant: Council of Scientific & Industrial Research

Inventor： Dumbala Srinivasa Reddy ,  Dhanasekaran Shanmugam ,  Remya Ramesh ,  Anurag Shukla ,  Meenakshi Anil Belekar

IPC: C07F7/08 ,  C07D413/10 ,  A61P33/06

CPC classification number: C07F7/0816 ,  A61K31/695 ,  A61K45/06 ,  A61P33/06 ,  C07D413/10 ,  Y02A50/411

Abstract: The present invention discloses a silicon incorporated quinoline of formula (I) wherein, X, Y, A, R1 and R2 are as described. The present invention further discloses a process for the preparation of silicon incorporated quinolines of formula I; a pharmaceutical composition comprising silicon incorporated quinolines of formula (I) or pharmaceutically acceptable salt thereof. The present invention also discloses a method for treating diseases caused by Plasmodium falciparum or other coccidian parasites using the silicon incorporated quinolines of formula I or pharmaceutically acceptable salt thereof.

公开(公告)号：US10550135B2

公开(公告)日：2020-02-04

申请号：US16088695

申请日：2017-03-30

Applicant: Council of Scientific & Industrial Research

Inventor： Dumbala Srinivasa Reddy ,  Dhanasekaran Shanmugam ,  Remya Ramesh ,  Anurag Shukla ,  Meenakshi Anil Belekar

IPC: A61K31/695 ,  C07F7/08 ,  A61P33/06 ,  C07D413/10

Abstract: The present invention discloses a silicon incorporated quinoline of formula (I) wherein, X, Y, A, R1 and R2 are as described. The present invention further discloses a process for the preparation of silicon incorporated quinolines of formula I; a pharmaceutical composition comprising silicon incorporated quinolines of formula (I) or pharmaceutically acceptable salt thereof. The present invention also discloses a method for treating diseases caused by Plasmodium falciparum or other coccidian parasites using the silicon incorporated quinolines of formula I or pharmaceutically acceptable salt thereof.