公开(公告)号：US12077830B2

公开(公告)日：2024-09-03

申请号：US18097004

申请日：2023-01-13

申请人： Quest Diagnostics Investments LLC

发明人： Peter Lee ,  Raymond Huang ,  Kristin Ramos ,  Jules Chen ,  Michelle Tabb

IPC分类号： C12Q1/70 ,  A61P31/14 ,  C12N7/00 ,  C12Q1/68 ,  C12Q1/686 ,  G01N33/569 ,  A61K39/00

CPC分类号： C12Q1/701 ,  A61P31/14 ,  C12N7/00 ,  C12Q1/68 ,  C12Q1/686 ,  C12Q1/70 ,  G01N33/56983 ,  A61K39/00 ,  C12N2770/16021 ,  C12Q2600/106 ,  C12Q2600/112 ,  G01N2333/08 ,  C12Q1/686 ,  C12Q2521/107 ,  C12Q1/70 ,  C12Q2521/107

摘要： The present disclosure provides methods and compositions for determining whether a patient exhibiting acute gastroenteritis will benefit from treatment with therapeutic agents that inhibit Norovirus genogroup I (GI) or Norovirus genogroup II (GII). The methods disclosed herein are based on detecting Norovirus genogroup I (GI) and Norovirus genogroup II (GII) in a stool sample without extracting viral nucleic acids from a clinical specimen prior to performing real-time reverse transcription PCR. Kits for use in practicing the methods are also provided.

公开(公告)号：US12050214B2

公开(公告)日：2024-07-30

申请号：US18096754

申请日：2023-01-13

申请人： Patient Knowhow, Inc.

发明人： Devabhaktuni Srikrishna

IPC分类号： G01N33/497 ,  C12Q1/6869 ,  G01N1/22 ,  G01N15/06 ,  G01N15/075

CPC分类号： G01N33/497 ,  C12Q1/6869 ,  G01N1/2202 ,  G01N1/2205 ,  G01N1/2273 ,  G01N15/06 ,  G01N2001/2223 ,  G01N2001/2244 ,  G01N15/075 ,  G01N2033/4975 ,  G01N2333/01 ,  G01N2333/08

摘要： A bioaerosol detector is operated in accordance with one or more first inputs. Operating the bioaerosol detector includes filtering pathogens from the air, extracting genetic material from the filtered pathogens, and analyzing the extracted genetic material to identify the filtered pathogens. While operating the bioaerosol detector in accordance with the one or more first inputs, a change is identified in an operating condition for the bioaerosol detector. In response, the bioaerosol detector is operated in accordance with one or more second inputs. At least one input of the one or more second inputs is distinct from a respective input of the one or more first inputs.

公开(公告)号：US20240218055A1

公开(公告)日：2024-07-04

申请号：US18557741

申请日：2022-04-29

申请人： The U.S.A., as represented by the Secretary, Department of Health and Human Services

发明人： Mitchell Ho ,  Peter D. Kwong ,  Zhijian Duan ,  Yaping Sun ,  Sao-Fong Cheung ,  Jason J. Gorman

IPC分类号： C07K16/10 ,  A61K47/68 ,  A61P31/14 ,  G01N33/543 ,  G01N33/569

CPC分类号： C07K16/10 ,  A61K47/6841 ,  A61P31/14 ,  G01N33/543 ,  G01N33/56983 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  G01N2333/08

摘要： Single-domain monoclonal antibodies that specifically bind Lassa virus glycoprotein (GPC) are described. The single-domain antibodies (“nanobodies”) were isolated from camel (VHH) and shark variable new antigen (VNAR) phage display libraries panned against a stabilized form of the GPC trimer. The GPC-specific nanobodies, and conjugates thereof, can be used for the diagnosis and treatment of a Lassa virus infection.

公开(公告)号：US20240148850A1

公开(公告)日：2024-05-09

申请号：US17997749

申请日：2022-03-17

申请人： Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

发明人： Jing ZHANG ,  Zengjun LU ,  Kun LI ,  Pu SUN ,  Jian WANG ,  Yimei CAO ,  Huifang BAO ,  Zhixun ZHAO ,  Pinghua LI ,  Yuanfang FU ,  Xueqing MA ,  Hong YUAN ,  Xingwen BAI ,  Qiang ZHANG ,  Dong LI ,  Zaixin LIU

IPC分类号： A61K39/12 ,  A61K39/00 ,  C07K14/005 ,  G01N33/569

CPC分类号： A61K39/12 ,  C07K14/005 ,  G01N33/56983 ,  A61K2039/5252 ,  A61K2039/5254 ,  C12N2770/10022 ,  C12N2770/10034 ,  G01N2333/08

摘要： The present disclosure provides an N protein epitope mutation marker for preparing an epitope deletion-marked vaccine strain of type II porcine reproductive and respiratory syndrome virus (PRRSV) and use thereof, belonging to the technical field of biological products. In the mutation marker, one or more amino acids are mutated based on an epitope sequence at positions 92 to 103 of a C-terminal of an N protein of the type II PRRSV; and the epitope mutation marker has an amino acid sequence shown in SEQ ID NO: 1, where X1 is selected from the group consisting of T, P, and A; and X2 is selected from the group consisting of V and A.

公开(公告)号：US20230160883A1

公开(公告)日：2023-05-25

申请号：US17947411

申请日：2022-09-19

申请人： Yunnan Academy of Tobacco Agricultural Sciences

发明人： Ning JIANG ,  Zhenyuan XIA ,  Xiaotong GAI ,  Zhonglong LIN ,  Canhua LU ,  Changjun HUANG ,  Junhong MA ,  Xiaohan MO ,  Wei WU ,  Chunming LIU ,  Qiuqiang HOU ,  Jian GUO

IPC分类号： G01N33/531 ,  C12N5/12 ,  G01N33/543 ,  G01N33/569

CPC分类号： G01N33/531 ,  C12N5/12 ,  G01N33/54388 ,  G01N33/56983 ,  C12N2510/02 ,  G01N2333/08

摘要： This invention provides a tomato zonate spot virus detection reagent. Optimized gene encoding N protein of TZSV is expressed and purified to obtain N protein of TZSV, and two specific hybridoma cell lines are obtained, from which specific anti-TZSV monoclonal antibody could be obtained, respectively. Test strip for detecting tomato zonate spot virus is prepared with the monoclonal antibody. It is proven by experiments that the test strip of this invention is specific for TZSV, and can realize rapid detection of TZSV in leaves and other samples, with high sensitivity and convenient operation.

公开(公告)号：US20180291088A1

公开(公告)日：2018-10-11

申请号：US15526661

申请日：2015-11-13

申请人： The USA, as represented by the Secretary, Department of Health and Human Services ,  Institute for Research in Biomedicine ,  The Government of the United States as represented by the Secretary of the Army, Ft Detrick,Md ,  Humabs BioMed SA

发明人： Nancy Sullivan ,  Sabue Mulangu ,  Davide Corti ,  Antonio Lanzavecchia ,  Barney Graham ,  Jean-Jacques Muyembe-Tamfun ,  John Trefry ,  Julie Ledgerwood ,  Daphne Stanley

IPC分类号： C07K16/10 ,  G01N33/569

CPC分类号： C07K16/10 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56983 ,  G01N2333/08 ,  G01N2800/26

摘要： Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virususing the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virusinfection in a subject.

公开(公告)号：US20180251861A1

公开(公告)日：2018-09-06

申请号：US15759831

申请日：2017-04-12

申请人： REPUBLIC OF KOREA (NATIONAL FISHERIES RESEARCH AND DEVELOPMENT INSTITUTE)

发明人： Jae Hun CHEONG ,  Hyun Kook CHO ,  Mi So SEONG ,  Mi Young CHO ,  Myoung Ae PARK ,  Bo-Young JEE ,  Seong Don HWANG ,  Jee Youn HWANG

IPC分类号： C12Q1/70

CPC分类号： C12Q1/701 ,  G01N21/00 ,  G01N33/56983 ,  G01N2333/08

摘要： A biomarker composition includes, as an active ingredient, one or at least two polypeptides having 5 to 120 consecutive amino acids that are selected from the group consisting of an amino acid in which serine (S) at the 56th position is substituted with leucine (L), an amino acid in which serine (S) at the 8th position is substituted with asparagines (N), an amino acid in which threonine (T) at the 81st position is substituted with alanine (A), an amino acid in which valine (V) at the 88th position is substituted with alanine (A), an amino acid in which glycine (G) at the 117th position is substituted with asparatic acid (D), and an amino acid in which glutamic acid (E) at the 119th position is substituted with lysine (K), within an amino acid sequence of VHSV represented by SEQ ID NO: 1.

公开(公告)号：US10053494B2

公开(公告)日：2018-08-21

申请号：US15312582

申请日：2015-05-18

申请人： The Regents of the University of California

发明人： R. Holland Cheng ,  Li Xing ,  Chun Chieh Chen ,  Marie Stark

IPC分类号： C07K14/00 ,  C07K14/005 ,  A61K9/51

CPC分类号： C07K14/005 ,  A61K9/5169 ,  A61K2039/5258 ,  C12N2770/28122 ,  C12N2770/28123 ,  C12N2770/28142 ,  C12N2810/40 ,  G01N2333/08

摘要： Modified capsid proteins containing at least a portion of hepatitis E virus (HEV) open reading frame 2 (ORF2) having one or more cysteine residues in a surface variable loop or the C-terminus of HEV ORF2, or a portion thereof, are provided. The modified capsid proteins can be used to form hepatitis E virus (HEV) virus like particles (VLPs) having cysteine functional groups exposed on the outer-surface. The exposed cysteine functional groups can be modified via their thiol reactive group. For example, a bioactive agent, such as a cell-targeting ligand, can be conjugated to the one or more cysteines for targeted delivery of chemically activated nanocapsids.

公开(公告)号：US09975923B2

公开(公告)日：2018-05-22

申请号：US14213469

申请日：2014-03-14

申请人： The University of North Carolina at Chapel Hill

发明人： Ralph Steven Baric ,  Lisa Chon Lindesmith ,  Kari Moore Debbink ,  Eric Francis Donaldson ,  Jesica Anne Swanstrom

IPC分类号： A61K39/12 ,  A61K39/00 ,  C07K14/005 ,  G01N33/569

CPC分类号： C07K14/005 ,  C12N2770/16022 ,  C12N2770/16034 ,  C12N2770/36143 ,  G01N33/56983 ,  G01N2333/08

摘要： The present invention provides methods and compositions comprising a chimeric norovirus capsid protein comprising a norovirus VP1 major capsid protein backbone comprising a norovirus epitope selected from the group consisting of: a) Epitope A; b) Epitope B; c) Epitope C; d) Epitope D; e) Epitope E; f) Epitope F; and g) any combination of (a) through (f) above, wherein the norovirus epitope is from a norovirus strain that is different from the norovirus VP1 major capsid protein backbone.

公开(公告)号：US20180016322A1

公开(公告)日：2018-01-18

申请号：US15548883

申请日：2016-02-08

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITÉ CLAUDE BERNARD - LYON 1 ,  ENS - ECOLE NORMALE SUPÉRIEURE DE LYON ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： Olivier REYNARD ,  Viktor VOLCHKOV

IPC分类号： C07K16/10 ,  G01N33/569

CPC分类号： C07K16/10 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  G01N33/56983 ,  G01N2333/08

摘要： The present invention relates to antibodies or fragments thereof that specifically bind to glycoprotein (GP) of Ebola virus, and to their use for treating and diagnosing Ebola virus disease.