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公开(公告)号：US12077830B2
公开(公告)日：2024-09-03
申请号：US18097004
申请日：2023-01-13
发明人： Peter Lee , Raymond Huang , Kristin Ramos , Jules Chen , Michelle Tabb
CPC分类号： C12Q1/701 , A61P31/14 , C12N7/00 , C12Q1/68 , C12Q1/686 , C12Q1/70 , G01N33/56983 , A61K39/00 , C12N2770/16021 , C12Q2600/106 , C12Q2600/112 , G01N2333/08 , C12Q1/686 , C12Q2521/107 , C12Q1/70 , C12Q2521/107
摘要： The present disclosure provides methods and compositions for determining whether a patient exhibiting acute gastroenteritis will benefit from treatment with therapeutic agents that inhibit Norovirus genogroup I (GI) or Norovirus genogroup II (GII). The methods disclosed herein are based on detecting Norovirus genogroup I (GI) and Norovirus genogroup II (GII) in a stool sample without extracting viral nucleic acids from a clinical specimen prior to performing real-time reverse transcription PCR. Kits for use in practicing the methods are also provided.
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公开(公告)号：US10793924B2
公开(公告)日：2020-10-06
申请号：US16306203
申请日：2017-06-02
发明人： Peter Lee , Raymond Huang , Kristin Ramos , Jules Chen , Michelle Tabb
摘要： The present disclosure provides methods and compositions for determining whether a patient exhibiting acute gastroenteritis will benefit from treatment with therapeutic agents that inhibit Norovirus genogroup I (GI) or Norovirus genogroup II (GII). The methods disclosed herein are based on detecting Norovirus genogroup I (GI) and Norovirus genogroup II (GII) in a stool sample without extracting viral nucleic acids from a clinical specimen prior to performing real-time reverse transcription PCR. Kits for use in practicing the methods are also provided.
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公开(公告)号：US10316372B2
公开(公告)日：2019-06-11
申请号：US16124534
申请日：2018-09-07
发明人： Peter Lee , Lakshmi Nair , Albert Castro , Maria Vestal , Michelle Tabb
摘要： Provided herein are methods for determining the presence or absence of an enteroviruses and parechoviruses in a biological sample. The methods involve identifying the presence or absence of a target nucleic acids from the viruses using direct amplification from a biological sample without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids. Also provided are methods of diagnosis using the methods provided and compositions and kits for the practice of the methods.
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公开(公告)号：US20190062850A1
公开(公告)日：2019-02-28
申请号：US16124534
申请日：2018-09-07
发明人： Peter Lee , Lakshmi Nair , Albert Castro , Maria Vestal , Michelle Tabb
IPC分类号： C12Q1/70
摘要： Provided herein are methods for determining the presence or absence of an enteroviruses and parechoviruses in a biological sample. The methods involve identifying the presence or absence of a target nucleic acids from the viruses using direct amplification from a biological sample without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids. Also provided are methods of diagnosis using the methods provided and compositions and kits for the practice of the methods.
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公开(公告)号：US20230279513A1
公开(公告)日：2023-09-07
申请号：US18097004
申请日：2023-01-13
发明人： Peter Lee , Raymond Huang , Kristin Ramos , Jules Chen , Michelle Tabb
CPC分类号： C12Q1/701 , A61P31/14 , C12N7/00 , C12Q1/68 , C12Q1/70 , C12Q1/686 , G01N33/56983 , A61K39/00 , C12N2770/16021
摘要： The present disclosure provides methods and compositions for determining whether a patient exhibiting acute gastroenteritis will benefit from treatment with therapeutic agents that inhibit Norovirus genogroup I (GI) or Norovirus genogroup II (GII). The methods disclosed herein are based on detecting Norovirus genogroup I (GI) and Norovirus genogroup II (GII) in a stool sample without extracting viral nucleic acids from a clinical specimen prior to performing real-time reverse transcription PCR. Kits for use in practicing the methods are also provided.
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公开(公告)号：US11555223B2
公开(公告)日：2023-01-17
申请号：US17063078
申请日：2020-10-05
发明人： Peter Lee , Raymond Huang , Kristin Ramos , Jules Chen , Michelle Tabb
IPC分类号： A61K39/00 , A61K39/12 , A61K39/125 , C12N7/00 , C07K16/10 , C12Q1/70 , A61P31/14 , C12Q1/68 , C12Q1/686 , G01N33/569
摘要： The present disclosure provides methods and compositions for determining whether a patient exhibiting acute gastroenteritis will benefit from treatment with therapeutic agents that inhibit Norovirus genogroup I (GI) or Norovirus genogroup II (GII). The methods disclosed herein are based on detecting Norovirus genogroup I (GI) and Norovirus genogroup II (GII) in a stool sample without extracting viral nucleic acids from a clinical specimen prior to performing real-time reverse transcription PCR. Kits for use in practicing the methods are also provided.
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公开(公告)号：US20210095352A1
公开(公告)日：2021-04-01
申请号：US17063078
申请日：2020-10-05
发明人： Peter Lee , Raymond Huang , Kristin Ramos , Jules Chen , Michelle Tabb
摘要： The present disclosure provides methods and compositions for determining whether a patient exhibiting acute gastroenteritis will benefit from treatment with therapeutic agents that inhibit Norovirus genogroup I (GI) or Norovirus genogroup II (GII). The methods disclosed herein are based on detecting Norovirus genogroup I (GI) and Norovirus genogroup II (GII) in a stool sample without extracting viral nucleic acids from a clinical specimen prior to performing real-time reverse transcription PCR. Kits for use in practicing the methods are also provided.
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公开(公告)号：US10724111B2
公开(公告)日：2020-07-28
申请号：US16436709
申请日：2019-06-10
发明人： Peter Lee , Lakshmi Nair , Albert Castro , Maria Vestal , Michelle Tabb
IPC分类号： C12Q1/68 , C12P19/34 , C12Q1/70 , C07H21/04 , C12Q1/6874
摘要： Provided herein are methods for determining the presence or absence of an enteroviruses and parechoviruses in a biological sample. The methods involve identifying the presence or absence of a target nucleic acids from the viruses using direct amplification from a biological sample without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids. Also provided are methods of diagnosis using the methods provided and compositions and kits for the practice of the methods.
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公开(公告)号：US20190211408A1
公开(公告)日：2019-07-11
申请号：US16306203
申请日：2017-06-02
申请人： Peter Lee , Raymond Huang , Kristin Ramos , Jules Chen , Michelle Tabb , Quest Diagnostics Investments LLC
发明人： Peter Lee , Raymond Huang , Kristin Ramos , Jules Chen , Michelle Tabb
IPC分类号： C12Q1/70
摘要： The present disclosure provides methods and compositions for determining whether a patient exhibiting acute gastroenteritis will benefit from treatment with therapeutic agents that inhibit Norovirus genogroup I (GI) or Norovirus genogroup II (GII). The methods disclosed herein are based on detecting Norovirus genogroup I (GI) and Norovirus genogroup II (GII) in a stool sample without extracting viral nucleic acids from a clinical specimen prior to performing real-time reverse transcription PCR. Kits for use in practicing the methods are also provided.
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