公开(公告)号：US12059493B2

公开(公告)日：2024-08-13

申请号：US18492833

申请日：2023-10-24

申请人： Albert Einstein College of Medicine

发明人： Joel M. Friedman

IPC分类号： A61K31/12 ,  A61K9/00 ,  A61K9/06 ,  A61K31/05 ,  A61K31/121 ,  A61K31/352 ,  A61K31/366 ,  A61K31/4375 ,  A61K31/593 ,  A61K47/10 ,  A61K47/12 ,  A61P7/00 ,  A61P37/06

CPC分类号： A61K9/0014 ,  A61K9/06 ,  A61K31/05 ,  A61K31/12 ,  A61K31/121 ,  A61K31/352 ,  A61K31/366 ,  A61K31/4375 ,  A61K31/593 ,  A61K47/10 ,  A61K47/12 ,  A61P7/00 ,  A61P37/06

摘要： A transdermal formulation for the delivery of one or more active agents to a subject is provided. The formulation can be applied to the treatment of various diseases or conditions associated with an elevated CD38 level.

公开(公告)号：US20240226185A1

公开(公告)日：2024-07-11

申请号：US18513032

申请日：2023-11-17

申请人： Jack T. King

发明人： Jack T. King

IPC分类号： A61K35/644 ,  A61K9/08 ,  A61K31/045 ,  A61K31/121 ,  A61K36/534 ,  A61K47/02 ,  A61K47/10

CPC分类号： A61K35/644 ,  A61K9/08 ,  A61K31/045 ,  A61K31/121 ,  A61K36/534 ,  A61K47/02 ,  A61K47/10

摘要： For the purpose of treating a patient having Covid-19 (or another respiratory illness), a composition is formed from a pair of solutes via batch processing for inhalation by a person suffering from a respiratory illness. A first solute is formed by dissolving menthol crystals into high content ethanol. A second solute is formed by dissolving Manuka honey into normal saline. After mixing the two solutes separately, the two solutes may be mixed together and the final mixture may be administered to a human person via a nebulizer.

公开(公告)号：US20240058292A1

公开(公告)日：2024-02-22

申请号：US18259402

申请日：2021-12-31

申请人： Yaqin DENG

发明人： Yaqin DENG

IPC分类号： A61K31/22 ,  A61K31/045 ,  A61K31/10 ,  A61K31/121 ,  A61P35/00

CPC分类号： A61K31/22 ,  A61K31/045 ,  A61K31/10 ,  A61K31/121 ,  A61P35/00

摘要： Clean version of the Abstract A pharmaceutical composition for treating cancer, and a preparation method and use thereof are provided. The pharmaceutical composition includes an ester compound and dimethylsulfoxide (DMSO), a ketone compound and DMSO, or an alcohol compound and DMSO. The pharmaceutical composition is of a great value for a prevention and a treatment of cancer.

公开(公告)号：US20240033214A1

公开(公告)日：2024-02-01

申请号：US18487668

申请日：2023-10-16

申请人： Albert Einstein College of Medicine

发明人： Joel M. Friedman

IPC分类号： A61K9/00 ,  A61P7/00 ,  A61K47/12 ,  A61K31/366 ,  A61K47/10 ,  A61K31/121 ,  A61P37/06 ,  A61K9/06 ,  A61K31/05 ,  A61K31/12 ,  A61K31/352 ,  A61K31/4375 ,  A61K31/593

CPC分类号： A61K9/0014 ,  A61P7/00 ,  A61K47/12 ,  A61K31/366 ,  A61K47/10 ,  A61K31/121 ,  A61P37/06 ,  A61K9/06 ,  A61K31/05 ,  A61K31/12 ,  A61K31/352 ,  A61K31/4375 ,  A61K31/593

摘要： A transdermal formulation for the delivery of a nitric oxide booster or nitric oxide precursor to a subject is provided. The formulation can be applied to the treatment of various diseases or conditions by enhancing systemic level of nitric oxide.

公开(公告)号：US11826428B2

公开(公告)日：2023-11-28

申请号：US17540802

申请日：2021-12-02

申请人： Infirst Healthcare Limited

发明人： Robin M. Bannister ,  John Brew ,  Richard R. Reiley, III ,  Wilson Caparros Wanderley

IPC分类号： A61K9/08 ,  A61K31/00 ,  A61K47/44 ,  A61K47/14 ,  A61K9/14 ,  A61K31/121 ,  A61K31/137 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/222 ,  A61K31/357 ,  A61K31/366 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/522 ,  A61K31/60 ,  A61K31/616 ,  A61K47/10 ,  A61K47/22 ,  A61K9/20

CPC分类号： A61K47/14 ,  A61K9/08 ,  A61K9/145 ,  A61K31/121 ,  A61K31/137 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/222 ,  A61K31/357 ,  A61K31/366 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/522 ,  A61K31/60 ,  A61K31/616 ,  A61K47/10 ,  A61K47/22 ,  A61K47/44 ,  A61K9/2013 ,  Y02A50/30

摘要： The present specification discloses solid solution pharmaceutical compositions comprising hard fats, liquid lipids, and one or more cannabidiols, including a phytocannabinoid, an endocannabinoid, a synthetic cannabinoid, or a combination thereof, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.

公开(公告)号：US11793778B2

公开(公告)日：2023-10-24

申请号：US17157000

申请日：2021-01-25

申请人： AXCESS GLOBAL SCIENCES, LLC

发明人： Gary Millet

IPC分类号： A61K31/19 ,  A61K31/121

CPC分类号： A61K31/19 ,  A61K31/121 ,  A23V2200/3322

摘要： Compositions for delivering ketone bodies to a subject include one or more beta-hydroxybutyrate salts, one or more acetoacetate salts, beta-hydroxybutyric acid, and optionally acetoacetic acid. The compositions may optionally include one or more ketone body esters, such as one or more beta-hydroxybutyrate esters and/or one or more acetoacetate esters. An example composition contains about 2% to about 98% on a molar basis of the one or more beta-hydroxybutyrate salts and the one or more acetoacetate salts, about 2% to about 98% on a molar basis of the beta-hydroxybutyrate free acid and optionally the acetoacetate free acid, and optionally about 2% to about 98% on a molar basis of one or more ketone body esters.

公开(公告)号：US11786456B2

公开(公告)日：2023-10-17

申请号：US18306951

申请日：2023-04-25

申请人： Albert Einstein College of Medicine

发明人： Joel M. Friedman

IPC分类号： A61K31/12 ,  A61K9/00 ,  A61P7/00 ,  A61K47/12 ,  A61K31/366 ,  A61K47/10 ,  A61K31/121 ,  A61P37/06 ,  A61K9/06 ,  A61K31/05 ,  A61K31/352 ,  A61K31/4375 ,  A61K31/593

CPC分类号： A61K9/0014 ,  A61K9/06 ,  A61K31/05 ,  A61K31/12 ,  A61K31/121 ,  A61K31/352 ,  A61K31/366 ,  A61K31/4375 ,  A61K31/593 ,  A61K47/10 ,  A61K47/12 ,  A61P7/00 ,  A61P37/06

摘要： A transdermal formulation for the delivery of a nitric oxide booster or nitric oxide precursor to a subject is provided. The formulation can be applied to the treatment of various diseases or conditions by enhancing systemic level of nitric oxide.

公开(公告)号：US20190240271A1

公开(公告)日：2019-08-08

申请号：US16264993

申请日：2019-02-01

申请人： INFINITEC ACTIVOS, S.L.

发明人： Marisabel MOURELLE ,  Aimée VASCONCELOS ,  Ramona GALATOLA

IPC分类号： A61K36/15 ,  A61K31/121 ,  A61K9/127 ,  A61P17/00

CPC分类号： A61K36/15 ,  A61K9/0014 ,  A61K9/5123 ,  A61K31/12 ,  A61K31/121 ,  A61K36/9066 ,  A61K47/24 ,  A61K47/44 ,  A61P17/00 ,  A61K2300/00

摘要： The present invention provides topical compositions comprising pinus pinaster bark extract and curcumin, particularly in microcapsules and/or nanocapsules comprising phospholipids, and to their pharmaceutical use for the prevention and/or treatment of atopic dermatitis.

公开(公告)号：US20190231742A1

公开(公告)日：2019-08-01

申请号：US15952157

申请日：2018-04-12

申请人： Theodore B. VANITALLIE

发明人： Theodore B. VANITALLIE

IPC分类号： A61K31/381 ,  A61P37/08 ,  A61K9/00 ,  A61K31/12 ,  A61K31/22 ,  A61K31/045

CPC分类号： A61K31/381 ,  A61K9/0053 ,  A61K31/045 ,  A61K31/12 ,  A61K31/121 ,  A61K31/19 ,  A61K31/22 ,  A61P37/08

摘要： A nutritional agent that orally delivers a therapeutically effective amount of a ketone body selected from the group consisting of D-β-hydroxybutyrate (D-βOHB), acetoacetate (AcAc), acetone and any of their isoforms, in a carrier vehicle, to prevent and treat hypersensitivity and allergic disorders.

公开(公告)号：US20190083624A9

公开(公告)日：2019-03-21

申请号：US14155167

申请日：2014-01-14

申请人： Infirst Healthcare Limited

发明人： Robin M. Bannister ,  John Brew ,  Richard R. Reiley, III ,  Wilson Caparros Wanderley

IPC分类号： A61K47/14 ,  A61K31/192 ,  A61K47/10 ,  A61K31/357 ,  A61K31/616 ,  A61K47/22 ,  A61K31/4178 ,  A61K31/196 ,  A61K31/222 ,  A61K31/167 ,  A61K31/121 ,  A61K31/522 ,  A61K31/137 ,  A61K31/366 ,  A61K31/4184

CPC分类号： A61K47/14 ,  A61K9/08 ,  A61K31/121 ,  A61K31/137 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/222 ,  A61K31/357 ,  A61K31/366 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/522 ,  A61K31/60 ,  A61K31/616 ,  A61K47/10 ,  A61K47/22 ,  A61K47/44 ,  Y02A50/411

摘要： The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a severe pain in an individual using such pharmaceutical compositions.