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    Compositions and methods for increasing lean-to-fat mass ratio
    1.
    发明授权
    Compositions and methods for increasing lean-to-fat mass ratio 有权

    公开(公告)号：US12186297B2

    公开(公告)日：2025-01-07

    申请号：US17394649

    申请日：2021-08-05

    Applicant: AXCESS GLOBAL SCIENCES, LLC

    Inventor： Gary Millet

    IPC: A61K31/22 ,  A61K31/12 ,  A61K31/19

    Abstract: Disclosed herein are “ketone body-HMB” or “KB-HMB” compositions including a combination of: (1) hydroxymethyl butyrate; (2) a ketone body component such as beta-hydroxybutyrate (BHB) and/or acetoacetate; and (3) optionally a dietetically or pharmaceutically acceptable carrier. Also disclosed herein are methods of using such compositions for producing desired physiological effects, such as fat loss, in a mammal. The compositions beneficially enhance fat loss through ketosis while also reducing or eliminating muscle wasting and/or promoting muscle formation.

    Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate
    2.
    发明授权
    Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate 有权

    公开(公告)号：US11793778B2

    公开(公告)日：2023-10-24

    申请号：US17157000

    申请日：2021-01-25

    Applicant: AXCESS GLOBAL SCIENCES, LLC

    Inventor： Gary Millet

    IPC: A61K31/19 ,  A61K31/121

    CPC classification number: A61K31/19 ,  A61K31/121 ,  A23V2200/3322

    Abstract: Compositions for delivering ketone bodies to a subject include one or more beta-hydroxybutyrate salts, one or more acetoacetate salts, beta-hydroxybutyric acid, and optionally acetoacetic acid. The compositions may optionally include one or more ketone body esters, such as one or more beta-hydroxybutyrate esters and/or one or more acetoacetate esters. An example composition contains about 2% to about 98% on a molar basis of the one or more beta-hydroxybutyrate salts and the one or more acetoacetate salts, about 2% to about 98% on a molar basis of the beta-hydroxybutyrate free acid and optionally the acetoacetate free acid, and optionally about 2% to about 98% on a molar basis of one or more ketone body esters.

    KETONE BODY ESTERS OF S-BETA-HYDROXYBUTYRATE AND/OR S-1,3-BUTANEDIOL FOR MODIFYING METABOLIC FUNCTION
    4.
    发明申请
    KETONE BODY ESTERS OF S-BETA-HYDROXYBUTYRATE AND/OR S-1,3-BUTANEDIOL FOR MODIFYING METABOLIC FUNCTION 有权

    公开(公告)号：US20220133673A1

    公开(公告)日：2022-05-05

    申请号：US17555724

    申请日：2021-12-20

    Applicant: AXCESS GLOBAL SCIENCES, LLC

    Inventor： Gary Millet

    IPC: A61K31/22 ,  A61K31/19 ,  A61K9/00 ,  A61K31/047

    Abstract: Compositions and methods for producing elevated blood levels of ketone bodies and modifying metabolic function in a mammal. Compositions include at least one ester of S-beta-hydroxybutyrate and/or a mono- or di-ester of S-1,3-butanediol and at least one ketone body component. The ketone body component includes beta-hydroxybutyrate, acetoacetate, or both. The beta-hydroxybutyrate is R-beta-hydroxybutyrate, S-beta-hydroxybutyrate, or both. When the ketone body component is S-beta-hydroxybutyrate, the 1,3-butanediol is R-1,3-butanediol, S-1,3-butanediol, or both. Compositions may comprise a keto stack of multiple forms of ketone bodies.

    Compositions and methods for delivering cannabidiol and ketone bodies
    5.
    发明授权
    Compositions and methods for delivering cannabidiol and ketone bodies 有权

    公开(公告)号：US11129802B2

    公开(公告)日：2021-09-28

    申请号：US16551570

    申请日：2019-08-26

    Applicant: AXCESS GLOBAL SCIENCES, LLC

    Inventor： Gary Millet

    IPC: A61K31/19 ,  A61K31/05 ,  A61P3/04 ,  A61K47/14 ,  A61K47/10

    Abstract: Disclosed herein are “ketonnabidiol” or “ketannabidiol” compositions including a combination of: (1) cannabidiol (CBD) and/or cannabidiolic acid (CBDA); (2) a ketone body component such as beta-hydroxybutyrate (BHB) and/or acetoacetate; and (3) a dietetically or pharmaceutically acceptable carrier. Also disclosed herein are methods of using such ketonnabidiol compositions for producing desired physiological effects, such as fat loss, in a mammal. The ketonnabidiol compositions beneficially enhance fat loss through ketosis while also reducing the duration and/or severity of unpleasant “keto flu” symptoms typically associated with ketosis.

    Compositions and methods for delivering tetrahydrocannabinol and ketone bodies
    7.
    发明授权
    Compositions and methods for delivering tetrahydrocannabinol and ketone bodies 有权

    公开(公告)号：US10980772B2

    公开(公告)日：2021-04-20

    申请号：US16272328

    申请日：2019-02-11

    Applicant: AXCESS GLOBAL SCIENCES, LLC

    Inventor： Gary Millet

    IPC: A61K31/352 ,  A61K47/10 ,  A61K47/14 ,  A61P25/04 ,  A61P29/00 ,  A61P35/00 ,  A61P25/24 ,  A61K31/19

    Abstract: Disclosed herein are “ketannabis” (or “ketonnabis”) compositions including a combination of: (1) tetrahydrocannabinol (THC); (2) a ketone body component such as beta-hydroxybutyrate (BHB) and/or acetoacetate; and (3) a dietetically or pharmaceutically acceptable carrier. Also disclosed herein are methods of using such ketannabis compositions for producing desired physiological effects. The ketannabis compositions beneficially enhance the euphoric effects of THC without aggravating common side effects or even acting to reduce common side effects such as anxiety, disruption of short-term memory, appetite increases, heart rate increases, and blood pressure changes.

    COMPOSITIONS AND METHODS FOR DELIVERING TETRAHYDROCANNABINOL AND KETONE BODIES
    8.
    发明申请
    COMPOSITIONS AND METHODS FOR DELIVERING TETRAHYDROCANNABINOL AND KETONE BODIES 审中-公开

    公开(公告)号：US20200061021A1

    公开(公告)日：2020-02-27

    申请号：US16272328

    申请日：2019-02-11

    Applicant: AXCESS GLOBAL SCIENCES, LLC

    Inventor： Gary Millet

    IPC: A61K31/352 ,  A61K47/10 ,  A61K47/14 ,  A61P25/24 ,  A61P25/04 ,  A61P29/00 ,  A61P35/00

    Abstract: Disclosed herein are “ketannabis” (or “ketonnabis”) compositions including a combination of: (1) tetrahydrocannabinol (THC); (2) a ketone body component such as beta-hydroxybutyrate (BHB) and/or acetoacetate; and (3) a dietetically or pharmaceutically acceptable carrier. Also disclosed herein are methods of using such ketannabis compositions for producing desired physiological effects. The ketannabis compositions beneficially enhance the euphoric effects of THC without aggravating common side effects or even acting to reduce common side effects such as anxiety, disruption of short-term memory, appetite increases, heart rate increases, and blood pressure changes.

    NON-RACEMIC BETA-HYDROXYBUTYRATE COMPOUNDS AND COMPOSITIONS ENRICHED WITH THE R-ENANTIOMER AND METHODS OF USE
    9.
    发明申请
    NON-RACEMIC BETA-HYDROXYBUTYRATE COMPOUNDS AND COMPOSITIONS ENRICHED WITH THE R-ENANTIOMER AND METHODS OF USE 审中-公开

    公开(公告)号：US20190151267A1

    公开(公告)日：2019-05-23

    申请号：US16224408

    申请日：2018-12-18

    Applicant: AXCESS GLOBAL SCIENCES, LLC

    Inventor： Gary Millet

    IPC: A61K31/19 ,  A61K31/047 ,  A61K9/00

    CPC classification number: A61K31/19 ,  A61K9/0053 ,  A61K31/047

    Abstract: Ketogenic compositions including a non-racemic mixture of beta-hydroxybutyrate (BHB) enriched with the R-enantiomer are formulated to increase ketone body level in a subject. The non-racemic mixture of BHB is enriched with the R-enantiomer to elevate ketone bodies and increase the rate at which ketosis is achieved yet contains an amount of the S-enantiomer sufficient to provide alternative benefits as discussed herein. In some aspects a composition for increasing ketone body level in a subject contains a dietetically or pharmaceutically acceptable carrier and a non-racemic mixture of R-beta-hydroxybutyrate and S-beta-hydroxybutyrate, wherein the non-racemic mixture of R-beta-hydroxybutyrate and S-beta-hydroxybutyrate contains from about 55% to 98% by enantiomeric equivalents of the R-beta-hydroxybutyrate and from about 45% to about 2% by enantiomeric equivalents of S-beta-hydroxybutyrate enantiomer.

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