公开(公告)号：US20240182476A1

公开(公告)日：2024-06-06

申请号：US18450646

申请日：2023-08-16

Applicant: GILEAD SCIENCES, INC. ,  CARNA BIOSCIENCES, INC.

Inventor： Masaaki Sawa ,  Mai Arai ,  Ryoko Nakai ,  Hirokazu Matsumoto ,  Catherine Pugh ,  Eric Hu ,  Juan Guerrero ,  Jesse Jacobsen ,  Jonathan William Medley ,  Jie Xu ,  Latesh Lad ,  Leena Patel ,  Michael Graupe ,  Qingming Zhu ,  Stephen Holmbo ,  Tetsuya Kobayashi ,  Will Watkins ,  Yasamin Moazami ,  Suet C. Yeung ,  Julian A. Codelli ,  Heath A. Weaver

IPC: C07D487/04 ,  A61K31/395 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/55 ,  A61K31/553 ,  A61K31/695 ,  A61K31/704 ,  A61K31/7068 ,  A61K35/15 ,  A61K35/17 ,  A61K39/395 ,  A61K45/06 ,  C07D519/00 ,  C07F7/18

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/55 ,  A61K31/553 ,  A61K31/5545 ,  A61K31/695 ,  A61K31/704 ,  A61K31/7068 ,  A61K35/15 ,  A61K35/17 ,  A61K39/3955 ,  A61K45/06 ,  C07D519/00 ,  C07F7/1804

Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

公开(公告)号：US20220152014A1

公开(公告)日：2022-05-19

申请号：US17508267

申请日：2021-10-22

Applicant: Gilead Sciences, Inc.

Inventor： Peter A. Blomgren ,  Taryn Campbell ,  Jayaraman Chandrasekhar ,  Christopher T. Clark ,  Julian A. Codelli ,  Kevin S. Currie ,  Jeffrey E. Kropf ,  Yasamin Moazami ,  Nicole Nava ,  Leena Patel ,  Stephane Perreault ,  Jason K. Perry ,  Kassandra F. Sedillo ,  Natalie Seeger ,  Kirk L. Stevens ,  Jennifer Anne Treiberg ,  Suet C. Yeung ,  Zhongdong Zhao

IPC: A61K31/47 ,  A61K31/352 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/541 ,  C07D215/14 ,  C07D311/58 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/10 ,  C07D471/04 ,  C07D519/00

Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.

公开(公告)号：US20200163953A1

公开(公告)日：2020-05-28

申请号：US16667572

申请日：2019-10-29

Applicant: Gilead Sciences, Inc.

Inventor： Peter A. Blomgren ,  Taryn Campbell ,  Jayaraman Chandrasekhar ,  Christopher T. Clark ,  Julian A. Codelli ,  Kevin S. Currie ,  Jeffrey E. Kropf ,  Yasamin Moazami ,  Nicole Nava ,  Leena Patel ,  Stephane Perreault ,  Jason K. Perry ,  Kassandra F. Sedillo ,  Natalie Seeger ,  Kirk L. Stevens ,  Jennifer Anne Treiberg ,  Suet C. Yeung ,  Zhongdong Zhao

IPC: A61K31/47 ,  A61K31/541 ,  C07D215/14 ,  C07D413/12 ,  A61K31/5377 ,  A61K31/513 ,  C07D401/10 ,  A61K31/4709 ,  C07D417/10 ,  C07D403/10 ,  A61K31/497 ,  A61K31/501 ,  C07D405/10 ,  C07D413/14 ,  C07D471/04 ,  C07D519/00 ,  C07D311/58 ,  A61K31/352

Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.

公开(公告)号：US10227350B2

公开(公告)日：2019-03-12

申请号：US15711902

申请日：2017-09-21

Applicant: Gilead Sciences, Inc.

Inventor： Jayaraman Chandrasekhar ,  Leena Patel ,  Stephane Perreault ,  Gary Phillips ,  Nicholas Alexander Till ,  Jennifer Anne Treiberg

IPC: A61K31/4709 ,  C07D401/14 ,  C07D487/04 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/4409 ,  A61K31/506 ,  A61K31/519 ,  C07D487/02

Abstract: The present application provides the compounds of formula I or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein s, t, n, R1, R2, R3, R4, R5, and R6 are as described herein.

公开(公告)号：US20180086768A1

公开(公告)日：2018-03-29

申请号：US15711902

申请日：2017-09-21

Applicant: Gilead Sciences, Inc.

Inventor： Jayaraman Chandrasekhar ,  Leena Patel ,  Stephane Perreault ,  Gary Phillips ,  Nicholas Alexander Till ,  Jennifer Anne Treiberg

IPC: C07D487/04 ,  C07D417/14 ,  C07D413/14 ,  C07D403/14

CPC classification number: C07D487/04 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/4409 ,  A61K31/4709 ,  A61K31/506 ,  A61K31/519 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/02

Abstract: The present application provides the compounds of formula I or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein s, t, n, R1, R2, R3, R4, R5, and R6 are as described herein.

公开(公告)号：US20230041518A1

公开(公告)日：2023-02-09

申请号：US17379175

申请日：2021-07-19

Applicant: Gilead Sciences, Inc.

Inventor： Peter A. Blomgren ,  Taryn Campbell ,  Jayaraman Chandrasekhar ,  Christopher T. Clark ,  Julian A. Codelli ,  Kevin S. Currie ,  Jeffrey E. Kropf ,  Yasamin Moazami ,  Nicole Nava ,  Leena Patel ,  Stephane Perreault ,  Jason K. Perry ,  Kassandra F. Sedillo ,  Natalie Seeger ,  Kirk L. Stevens ,  Jennifer Anne Treiberg ,  Suet C. Yeung ,  Zhongdong Zhao

IPC: A61K31/47 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/501 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5355 ,  A61K31/541 ,  A61K45/06 ,  C07D215/14 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.

公开(公告)号：US11116760B2

公开(公告)日：2021-09-14

申请号：US16667306

申请日：2019-10-29

Applicant: Gilead Sciences, Inc.

Inventor： Peter A. Blomgren ,  Taryn Campbell ,  Jayaraman Chandrasekhar ,  Christopher T. Clark ,  Julian A. Codelli ,  Kevin S. Currie ,  Jeffrey E. Kropf ,  Yasamin Moazami ,  Nicole Nava ,  Leena Patel ,  Stephane Perreault ,  Jason K. Perry ,  Kassandra F. Sedillo ,  Natalie Seeger ,  Kirk L. Stevens ,  Jennifer Anne Treiberg ,  Suet C. Yeung ,  Zhongdong Zhao

IPC: C07D413/14 ,  A61K31/5377 ,  A61K31/47 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/501 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5355 ,  A61K31/541 ,  A61K45/06 ,  C07D215/14 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.

公开(公告)号：US10214519B2

公开(公告)日：2019-02-26

申请号：US15711957

申请日：2017-09-21

Applicant: Gilead Sciences, Inc.

Inventor： Jayaraman Chandrasekhar ,  Julian Andrew Codelli ,  Devan Naduthambi ,  Leena Patel ,  Stephane Perreault ,  Gary Phillips ,  Kassandra F. Sedillo ,  Jennifer Anne Treiberg ,  Joshua Van Veldhuizen ,  William J. Watkins

IPC: C07D413/14 ,  A61K31/5377 ,  C07D417/14 ,  C07D405/14 ,  C07D409/14 ,  A61K45/06

Abstract: The present application provides the compounds of formula I or IA or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein s, t, m, n, R1, R2, R3, R4, R5, R6 and R7 are as described herein.

公开(公告)号：US20180086747A1

公开(公告)日：2018-03-29

申请号：US15711957

申请日：2017-09-21

Applicant: Gilead Sciences, Inc.

Inventor： Jayaraman Chandrasekhar ,  Julian Andrew Codelli ,  Devan Naduthambi ,  Leena Patel ,  Stephane Perreault ,  Gary Phillips ,  Kassandra F. Sedillo ,  Jennifer Anne Treiberg ,  Joshua Van Veldhuizen ,  William J. Watkins

IPC: C07D413/14 ,  C07D417/14 ,  C07D409/14 ,  C07D405/14 ,  A61K31/5377

CPC classification number: C07D413/14 ,  A61K31/5377 ,  A61K45/06 ,  A61K2300/00 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14

Abstract: The present application provides the compounds of formula I or IA or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein s, t, m, n, R1, R2, R3, R4, R5, R6 and R7 are as described herein.

公开(公告)号：US20180065953A1

公开(公告)日：2018-03-08

申请号：US15680045

申请日：2017-08-17

Applicant: Gilead Sciences, Inc.

Inventor： Jerry Evarts ,  Joshua A. Kaplan ,  Musong Kim ,  Devan Naduthambi ,  Leena Patel ,  Stephane Perreault ,  Gary Phillips ,  Lafe J. Purvis, II ,  Kirk L. Stevens ,  Jennifer Anne Treiberg

IPC: C07D403/12 ,  C07D491/107 ,  C07D409/14 ,  C07D413/14 ,  C07D401/14 ,  C07D403/14

CPC classification number: C07D403/12 ,  C07D401/14 ,  C07D403/14 ,  C07D409/14 ,  C07D413/14 ,  C07D491/107

Abstract: The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors of formula (J), or pharmaceutically acceptable salts thereof, in which A, n, m, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. These compounds are useful for treatment of conditions mediated by one or more PI3K isoforms. The present disclosure further provides pharmaceutical compositions that include a compound of formula (J), or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by one or more PI3K isoforms.