- 专利标题： SUBSTITUTED 2-PYRIDONE TRICYCLIC COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME
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申请号： US16978117申请日： 2019-03-11
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公开(公告)号： US20210017186A1公开(公告)日： 2021-01-21
- 发明人: Shuai Chen , Bruce D. Dorsey , Yi Fan , Dimitar B. Gotchev , Jorge Quintero
- 申请人： Arbutus Biopharma Corporation
- 申请人地址： CA Burnaby
- 专利权人： Arbutus Biopharma Corporation
- 当前专利权人： Arbutus Biopharma Corporation
- 当前专利权人地址： CA Burnaby
- 国际申请： PCT/US2019/021557 WO 20190311
- 主分类号： C07D493/04
- IPC分类号： C07D493/04 ; C07D493/14 ; C07D471/04 ; C07D215/02 ; C07D221/04
摘要：
The present invention includes in one aspect substituted 2-oxo-1,2,5,6-tetrahydrobenzo[h]quinoline-3-carboxylic acids, analogues thereof, and compositions comprising the same, which can be used to treat and/or prevent hepatitis B virus (HBV) infection and/or hepatitis D virus (HDV) in a patient. In certain embodiments, the invention provides a compound of formula (I), or a salt, solvate, geometric isomer, stereoisomer, tautomer, and any mixtures thereof:
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