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公开(公告)号：US12194088B2
公开(公告)日：2025-01-14
申请号：US18158940
申请日：2023-01-24
Applicant: Emory University , Indian Institute of Science
Inventor： Rama Rao Amara , Andrew Jones , Raghavan Varadarajan
Abstract: This disclosure relates to methods of promoting immune responses against HIV and compositions related thereto. In certain embodiments, this disclosure relates to methods of vaccinating for HIV comprising administering to the subject a priming composition followed by a boosting composition. In certain embodiments, the priming composition comprises a recombinant virus such as recombinant MVA that encodes an Env protein of HIV or segment thereof. In certain embodiments, the boosting composition comprises a trimeric cyclically permuted gp120 chimeric protein reported herein or DNA encoding the same.
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2.发明授权
公开(公告)号：US12119914B2
公开(公告)日：2024-10-15
申请号：US17726129
申请日：2022-04-21
Inventor： Ashok Kumar Reddy Chavva , Neelesh B Mehta , Shubham Khunteta , Sripada Kadambar , Anirudh Reddy Godala , Chaiman Lim
IPC: H04B7/06 , H04B17/318
CPC classification number: H04B7/0695 , H04B17/318
Abstract: A method is provided. The method includes receiving, by a User Equipment (UE), a plurality of transmit (Tx) beams from a Base Station (BS), on a plurality of receive (Rx) beams. The method includes determining the beam parameters associated with a plurality of Tx and Rx beam pairs changing at a frequency above a first threshold. The method includes deriving a beam selection metric for the plurality of Tx and Rx beam pairs using the associated beam parameters. The method includes identifying a subset of Tx and Rx beam pairs from the plurality of Tx and Rx beam pairs with the beam selection metric above a second threshold. The method includes prioritizing scanning of the identified subset of Tx and Rx beam pairs to select a Tx and Rx beam pair for communication.
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公开(公告)号：US12106679B2
公开(公告)日：2024-10-01
申请号：US16525968
申请日：2019-07-30
Applicant: INDIAN INSTITUTE OF SCIENCE
Inventor： Anirudh Katti , Shanthanu Chakravarthy , Gondi Kondaiah Ananthasuresh
CPC classification number: G09B23/285 , A61B1/00131 , G09B9/00
Abstract: The present disclosure discloses a compliant mechanism (100) for application of radial resistance on a simulation endoscope (101). The mechanism (100) comprises a support plate (102), a ring member (103) rotatably mounted on the support plate (102) and a plurality of flexible beam assemblies (104) configured in an inner circumference of the ring member (103). The plurality of flexible beam assemblies (104) comprises a first beam (104a) connectable to the ring member (103) and a second beam (104b) connectable to the support plate (102), the circular motion of at least one of the support plate (102) and the ring member (103), relative to each other, moves the plurality of flexible beam assemblies (104) radially inward and radially outward to selectively apply radial resistance on the simulation endoscope (101). The complaint mechanism (100) of present disclosure are joint less mechanisms which are free from backlash and friction in joints.
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4.发明公开
公开(公告)号：US20240262869A1
公开(公告)日：2024-08-08
申请号：US18004065
申请日：2021-06-29
Applicant: Indian Institute of Science , MYNVAX PRIVATE LIMITED
Inventor： Raghavan VARADARAJAN , Sameer Kumar MALLADI , Shahbaz AHMED , Suman PANDEY , Randhir SINGH
IPC: C07K14/005 , A61K9/00 , A61K39/215 , A61P31/14
CPC classification number: C07K14/005 , A61K9/0019 , A61K39/215 , A61P31/14 , C12N2770/20022 , C12N2770/20034 , C12N2770/20071
Abstract: The present disclosure discloses the polypeptide fragment having an amino acid sequence with at least 95% identity to the amino acid sequence selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 4, and SEQ ID NO: 6. The present disclosure also discloses nucleic acid fragment encoding the polypeptide fragment as described herein. Moreover, the present disclosure also discloses recombinant construct, recombinant vector and recombinant host cells. Also disclosed herein is an immunogenic composition comprising the polypeptide fragment as described herein, and a method for preparing the said immunogenic composition. The immunogenic composition is in form of vaccine. The polypeptide fragment and/or immunogenic composition is capable of eliciting protection against severe acute respiratory syndrome coronavirus 2. A kit comprising the polypeptide, or the immunogenic composition as described herein is also disclosed.
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公开(公告)号：US20240109777A1
公开(公告)日：2024-04-04
申请号：US18127941
申请日：2023-03-29
Inventor： Navita JAKHAR , Surjeet SINGH
IPC: C01B19/00
CPC classification number: C01B19/007 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2004/30 , C01P2004/64 , C01P2006/10 , C01P2006/32 , C01P2006/40
Abstract: The present disclosure generally relates to an all room-temperature, cost effective and highly-reproducible method for producing phase-pure nanostructured Ag2Te pellets that does not require spark-plasma sintering or high-temperature vacuum furnaces, while produces bulk and dense pellet materials with superior thermoelectric properties.
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公开(公告)号：US20240062161A1
公开(公告)日：2024-02-22
申请号：US18385288
申请日：2023-10-30
Applicant: INDIAN INSTITUTE OF SCIENCE (IISC)
Inventor： Balan GURUMOORTHY , Moothedath Chandran KUMARI
IPC: G06Q10/10 , G06Q10/101
CPC classification number: G06Q10/103 , G06Q10/101
Abstract: In one example, a system for product designing includes a storage unit and an interaction system communicably coupled with the storage unit. The interaction system includes at least one processor and a memory. The interaction system operates by provisioning an access to a at least one user and receive a communication from the at least one user for designing a product. The interaction system receives a reply from the at least one user and facilitates interaction among the at least one user based on the reply received from the at least one user to create a group of users. The group of users are provided with at least one designing tool for designing the product.
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7.发明公开
公开(公告)号：US20240046133A1
公开(公告)日：2024-02-08
申请号：US18258691
申请日：2022-05-27
Inventor： Shouvik DATTA , Amit BHUNIA , Mohamed HENINI , Maryam Al HUWAYZ , Mohit Kumar SINGH
CPC classification number: G06N10/40 , H03K17/92 , H01L31/035218
Abstract: The present disclosure provides method and system, which use multiple of excitonic BEC(s) and/or excitonic matter-wave(s) and/or excitonic superfluid(s) as a platform to generate multiple (from a few to even millions or more) long-lived Qubits in any conceivable multi-dimensional hybrid nano structure(s), mostly using semiconductor material(s) and/or device structure(s) at any temperature in between 0-500K, and that can sustain any quantum coherence for a much longer time scales of microseconds or milliseconds or even more, but not limited to these time scales for any conceivable faster device operation(s) as well. The macroscopic quantum states of the generated Qubits are easily controllable with applied voltage(s) (dc and/or ac) and/or electrical power, and/or light beam(s), and are easily integrated with semiconductor fabrication techniques for quicker and wider adaptation of Quantum technologies.
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公开(公告)号：US11872212B2
公开(公告)日：2024-01-16
申请号：US17873246
申请日：2022-07-26
Inventor： Chilla Malla Reddy , Surojit Bhunia , Rituparno Chowdhury , Ishita Ghosh
IPC: C07D403/06 , C07C229/60 , A61K31/417
CPC classification number: A61K31/417
Abstract: The invention provides non-centrosymmetric organic crystals which show exceptional self-healing properties. More particularly, the present invention provides non-centrosymmetric substituted imidazole and Dialkyl 4,4′-methylenebis(azanediyl)dibenzoate Crystals and a process for preparation thereof. These highly crystalline materials, when broken into pieces, can self-propel and re-join in the blink of an eye and repair themselves so precisely that they become indistinguishable from the undisturbed materials.
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公开(公告)号：US20240003921A1
公开(公告)日：2024-01-04
申请号：US18032196
申请日：2021-12-15
Applicant: INDIAN INSTITUTE OF SCIENCE
Inventor： Siva UMAPATHY , Venkatesh KALIAPERUMAL , Ria MUKHERJEE
IPC: G01N33/92 , G01N21/65 , G01N21/3577
CPC classification number: G01N33/92 , G01N21/65 , G01N21/3577 , G01N2800/32
Abstract: The invention provides a method for rapid detection of the viability of microorganisms. The method includes capturing a first unique signature with respect to a first lipid component, capturing a second unique signature with respect to a second lipid component, transforming each of the first lipid signatures and second lipid signatures to obtain amplified signatures, comparing the amplified signatures to obtain a first ratio and repeating the abovementioned steps at least one more time to obtain a second ratio. The alteration in the first ratio and the second ratio provides the indication for cardiovascular disorder.
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公开(公告)号：US11707738B2
公开(公告)日：2023-07-25
申请号：US16954140
申请日：2018-12-14
Applicant: Indian Institute of Science
Inventor： Jatin Panwar , Rahul Roy , Usama Ahmed Abbasi , Prakhar Jain , Viswanathan Kumaran
CPC classification number: B01L3/502715 , B01L3/502707 , B01L3/502761 , B81B1/006 , B81C1/00119 , G01N15/1031 , G01N15/1056 , B01L2200/0647 , B01L2200/12 , B01L2300/0645 , B01L2300/0887 , B81B2201/057 , B81B2203/0338 , B81B2203/04
Abstract: The present disclosure provides a microfluidic device comprising a set of micro-structured electrodes. The electrodes are made of a fusible alloy such as Field's Metal and are patterned on a layer of PDMS. The molten fusible alloy is poured over the patterned PDMA layer and a suction force is applied to ensure uniformity of flow of the molten metal. A second layer comprising a flow channel orthogonal to the direction of the micro-structured electrodes is disposed under the first layer to form the microfluidic device. The device shows enhanced sensitivity to RBC detection at high frequencies that are also bio-compatible (above 2 MHz). Multiple layers of the micro-structures electrodes can be sandwiched between layers of flow channels to provide a 3D microfluidic device.
