公开(公告)号：US20230346917A1

公开(公告)日：2023-11-02

申请号：US17918304

申请日：2021-04-03

申请人： NOVOSCOPE IP LIMITED

发明人： Jasper CLUBE

IPC分类号： C12N7/00 ,  A61P31/14 ,  C12N15/86 ,  A61K9/00 ,  A61K39/215

CPC分类号： A61K39/215 ,  A61K9/0078 ,  A61P31/14 ,  C12N7/00 ,  C12N15/86 ,  A61K2039/5258 ,  C12N2770/20022 ,  C12N2770/20023 ,  C12N2770/20034 ,  C12N2770/20043 ,  C12N2770/20051 ,  C12N2770/20062

摘要： The invention provides competitive particles, such as virus-like particles, RNAs and DNAs for the treatment or prevention of viral infections and methods of using such particles for treating or preventing or reducing the risk of viral infections (or symptoms thereof) in a subject, such as a human or animal subject. For example, the method herein is a method of reducing or reducing the establishment of a zoonotic population of a virus in an animal, such as a livestock or wild animal (eg, a bat, camelid or a Pholidota (eg, a pangolin)).

公开(公告)号：US08980281B2

公开(公告)日：2015-03-17

申请号：US12704928

申请日：2010-02-12

申请人： Pei-Wen Hsiao ,  Chia-Ying Wu ,  Yi-Chun Yeh

发明人： Pei-Wen Hsiao ,  Chia-Ying Wu ,  Yi-Chun Yeh

IPC分类号： A61K39/42 ,  C12P21/00 ,  C12N9/26 ,  C07K16/08 ,  C12N5/07 ,  C12N15/00 ,  A61P31/16 ,  A61K39/215 ,  A61K39/145 ,  C07K14/005 ,  A61K39/00

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K39/215 ,  A61K2039/5258 ,  C07K14/005 ,  C07K16/1018 ,  C12N2760/16034 ,  C12N2760/16122 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2770/20022 ,  C12N2770/20023 ,  C12N2770/20034 ,  C12N2830/006 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2469/10 ,  G01N2469/20

摘要： Virus-like particles (VLPs) of mammalian-hosted viruses, such as SARS-CoV and influenza viruses, have been recombinantly produced from Vero cells. The VLPs closely emulate the exterior of authentic virus particles and are highly immunogenic. They can elicit not only humoral but also cellular immune responses in a mammal. Compositions and methods related to the VLPs are also described.

摘要翻译： 从Vero细胞重组产生哺乳动物宿主病毒（如SARS-CoV和流感病毒）的病毒样颗粒（VLP）。 VLP密切模仿真实病毒颗粒的外观，具有高度的免疫原性。 它们可以引起哺乳动物体液，但也可引起细胞免疫反应。 还描述了与VLP相关的组合物和方法。

公开(公告)号：US20130344100A1

公开(公告)日：2013-12-26

申请号：US13992893

申请日：2011-12-22

申请人： Marc-Andre D'Aoust ,  Manon Couture ,  Pierre-Olivier Lavoie ,  Louis-Philippe Vezina

发明人： Marc-Andre D'Aoust ,  Manon Couture ,  Pierre-Olivier Lavoie ,  Louis-Philippe Vezina

IPC分类号： A61K39/295 ,  C07K14/005

CPC分类号： A61K39/295 ,  A61K2039/5258 ,  C07K14/005 ,  C07K2319/03 ,  C12N7/00 ,  C12N15/8257 ,  C12N15/8258 ,  C12N2710/16723 ,  C12N2710/16751 ,  C12N2740/16023 ,  C12N2740/16034 ,  C12N2740/16051 ,  C12N2740/16134 ,  C12N2760/14123 ,  C12N2760/14134 ,  C12N2760/14151 ,  C12N2760/16123 ,  C12N2760/20123 ,  C12N2760/20134 ,  C12N2760/20151 ,  C12N2770/20023 ,  C12N2770/20034 ,  C12N2770/20051

摘要： A method of producing a virus like particle (VLP) in a plant, and compositions comprising VLPs, are provided. The method involves introducing a nucleic acid comprising a regulatory region active in the plant and operatively linked to a chimeric nucleotide sequence encoding, in series, an ectodomain from a virus trimeric surface protein or fragment thereof, fused to an influenza transmembrane domain and cytoplasmic tail, into the plant, or portion of the plant, the ectodomain is from a non-influenza virus trimeric surface protein and heterologous with respect to the influenza transmembrane domain, and the cytoplasmic tail. The plant or portion of the plant are incubated under conditions that permit the expression of the nucleic acid, thereby producing the VLP. A VLP produced by this method are also provided.

摘要翻译： 提供了一种在植物中生产病毒样颗粒（VLP）的方法，以及包含VLP的组合物。 该方法包括引入包含在植物中有活性的调节区的核酸，并可操作地连接到嵌合核苷酸序列，该嵌合核苷酸序列串联编码融合到流感跨膜结构域和细胞质尾的病毒三聚体表面蛋白或其片段的胞外域， 进入植物或植物的一部分，胞外域是非流感病毒三聚体表面蛋白，并且与流感跨膜结构域和细胞质尾部是异源的。 植物或植物的一部分在允许核酸表达的条件下温育，从而产生VLP。 还提供了通过该方法生产的VLP。

公开(公告)号：US08551756B2

公开(公告)日：2013-10-08

申请号：US12689826

申请日：2010-01-19

申请人： Gale Smith ,  Peter Pushko

发明人： Gale Smith ,  Peter Pushko

IPC分类号： C12N7/00 ,  C12N7/04

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K2039/5258 ,  C07H21/04 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/14143 ,  C12N2760/16011 ,  C12N2760/16122 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2760/16222 ,  C12N2760/16223 ,  C12N2760/16234 ,  C12N2760/18522 ,  C12N2760/18523 ,  C12N2770/20022 ,  C12N2770/20023 ,  C12N2770/20034 ,  Y02A50/386 ,  Y02A50/388

摘要： This invention discloses a method of increasing production of virus-like particles comprising expressing an avian influenza matrix protein. The invention also comprises methods of making and using said VLPs.

摘要翻译： 本发明公开了一种增加包含表达禽流感基因蛋白质的病毒样颗粒的生产的方法。 本发明还包括制备和使用所述VLP的方法。

公开(公告)号：US20100184192A1

公开(公告)日：2010-07-22

申请号：US12689826

申请日：2010-01-19

申请人： Gale Smith ,  Peter Pushko

发明人： Gale Smith ,  Peter Pushko

IPC分类号： C12N7/00

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K2039/5258 ,  C07H21/04 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/14143 ,  C12N2760/16011 ,  C12N2760/16122 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2760/16222 ,  C12N2760/16223 ,  C12N2760/16234 ,  C12N2760/18522 ,  C12N2760/18523 ,  C12N2770/20022 ,  C12N2770/20023 ,  C12N2770/20034 ,  Y02A50/386 ,  Y02A50/388

摘要： This invention discloses a method of increasing production of virus-like particles comprising expressing an avian influenza matrix protein. The invention also comprises methods of making and using said VLPs

摘要翻译： 本发明公开了一种增加包含表达禽流感基因蛋白质的病毒样颗粒的生产的方法。 本发明还包括制备和使用所述VLP的方法

公开(公告)号：US20050002953A1

公开(公告)日：2005-01-06

申请号：US10839729

申请日：2004-05-04

申请人： Jens Herold

发明人： Jens Herold

IPC分类号： A61K39/215 ,  C07K14/165 ,  C12N7/00 ,  C12N7/04 ,  C12Q1/70 ,  A61K39/12

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/215 ,  A61K2039/523 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/542 ,  A61K2039/585 ,  C07K14/005 ,  C12N2770/20022 ,  C12N2770/20023 ,  C12N2770/20034 ,  C12Q1/70

摘要： The present disclosure describes a system for making SARS-CoV-virus-like particles (SARS-CoV-VLPs) comprising one or more recombinant vectors which express the SARS-CoV E-protein, the SARS-CoV M-protein, and the SARS-CoV S-protein. Additionally, the present disclosure describes methods of inducing an immune response in a subject comprising administering to the subject a nucleic acid encoding the SARS-CoV E-protein, the SARS-CoV M-protein, and the SARS-CoV S-protein. Methods of inducing an immune response in a subject comprising administering to the subject SARS-CoV-VLPs are also disclosed.

摘要翻译： 本公开描述了一种制备包含一种或多种表达SARS-CoV E蛋白，SARS-CoV M蛋白和SARS的重组载体的SARS-CoV病毒样颗粒（SARS-CoV-VLP）的系统 -CoV S-蛋白。 此外，本公开描述了在受试者中诱导免疫应答的方法，包括向受试者施用编码SARS-CoV E蛋白，SARS-CoV M-蛋白和SARS-CoV S-蛋白的核酸。 还公开了在受试者中诱导免疫应答的方法，包括给予受试者SARS-CoV-VLP。

公开(公告)号：US20240316169A1

公开(公告)日：2024-09-26

申请号：US18576623

申请日：2022-07-01

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Andrew J. Murphy ,  Christos KYRATSOUS ,  Alina BAUM ,  Christopher PETRO

IPC分类号： A61K39/00 ,  A61K39/145 ,  A61K39/215 ,  A61K39/42 ,  A61P37/04

CPC分类号： A61K39/0008 ,  A61K39/145 ,  A61K39/215 ,  A61K39/42 ,  A61P37/04 ,  A61K2039/53 ,  A61K2039/545 ,  C12N2770/20023 ,  C12N2770/20052

摘要： Described herein are methods and compositions for directing an antibody response in a subject away from one or more first epitopes of an antigen (e.g., immunodominant epitopes of a vaccine antigen) and towards one or more second epitopes of the antigen by administering one or more antibodies targeting the one or more first epitopes of the antigen.

公开(公告)号：US11952400B2

公开(公告)日：2024-04-09

申请号：US17232952

申请日：2021-04-16

申请人： TECON BIOPHARMACEUTICAL CO., LTD.

发明人： Sun He ,  Yiping Pan ,  Guoqing Zhang ,  Pengxian Yan ,  Na Xi ,  Miaomiao Guo ,  Shengdong Xiao ,  Tianzeng Li ,  Rui Han ,  Yumeng Wang ,  Jiubin Du ,  Pei Zheng ,  Jian Cao

IPC分类号： C07K14/005 ,  A61K39/108 ,  A61K39/15 ,  C07K14/245 ,  C12N7/00 ,  A61K39/00

CPC分类号： C07K14/005 ,  A61K39/0258 ,  A61K39/15 ,  C07K14/245 ,  C12N7/00 ,  A61K2039/5258 ,  A61K2039/552 ,  A61K2039/70 ,  C07K2319/40 ,  C12N2720/12322 ,  C12N2720/12323 ,  C12N2720/12334 ,  C12N2720/12352 ,  C12N2770/20022 ,  C12N2770/20023 ,  C12N2770/20034 ,  C12N2770/20052

摘要： Provided are a bovine rotavirus fusion protein and calf diarrhea multivalent vaccine. The bovine rotavirus fusion protein contains a VP6 fragment, wherein the VP6 fragment contains an amino acid sequence as represented by SEQ ID NO. 4, and at least one loop region of the following (a)˜(c) is substituted with an antigenic epitope derived from bovine coronavirus and/or an antigenic epitope derived from E. coli: (a) amino acid residues of sites 168-177; with an amino acid sequence as represented by SEQ ID NO. 1; (b) amino acid residues of sites 194-205; with an amino acid sequence as represented by SEQ ID NO. 2; and (a) amino acid residues of sites 296-316, with an amino acid sequence as represented by SEQ ID NO. 3, The bovine rotavirus fusion protein contains a plurality of antigenic epitopes, and can enable a host to generate a plurality of antibodies after immunizing the host.

公开(公告)号：US20230340028A1

公开(公告)日：2023-10-26

申请号：US18059171

申请日：2022-11-28

申请人： Boehringer Ingelheim Vetmedica GmbH

发明人： Annika KRAEMER-KUEHL ,  Thomas Min STEPHAN ,  Hans-Christian PHILIPP

IPC分类号： C07K14/005 ,  C12N7/00 ,  C12N15/85 ,  A61P31/14 ,  A61K39/215

CPC分类号： C07K14/005 ,  C12N7/00 ,  C12N15/85 ,  A61P31/14 ,  A61K39/215 ,  C12N2770/20023 ,  C12N2770/20022 ,  C12N2800/10

摘要： The present invention relates i.a. to a recombinant avian coronavirus spike protein or fragment thereof comprising a mutation at amino acid position 267 to Cysteine. Further, the present invention relates to an immunogenic composition comprising an avian coronavirus with such spike protein.

公开(公告)号：US20230227830A1

公开(公告)日：2023-07-20

申请号：US18002216

申请日：2021-06-18

申请人： HALO-BIO RNAI THERAPEUTICS, INC.

发明人： Todd HAUSER

IPC分类号： C12N15/113 ,  C07K14/005 ,  A01N63/60 ,  A01N25/26 ,  C12N15/115

CPC分类号： C12N15/1131 ,  C07K14/005 ,  A01N63/60 ,  A01N25/26 ,  C12N15/115 ,  C12N2310/14 ,  C12N2310/16 ,  C12N2770/20023

摘要： The present invention is directed to methods and compositions of RNA nanostructures for replication and/or subgenomic expression of gene modulating single-stranded RNA by RNA-directed RNA polymerase-like proteins and the use of such nanostructures for use in a variety of organisms.