公开(公告)号：US20240245804A1

公开(公告)日：2024-07-25

申请号：US18565727

申请日：2022-06-01

申请人： McMaster University ,  Ottawa Hospital Research Institute

发明人： Brian Lichty ,  Fuan Wang ,  Matthew Atherton ,  John Bell ,  Ragunath Singaravelu ,  Carolina Ilkow

IPC分类号： A61K48/00 ,  A61K38/45 ,  A61K45/06 ,  A61P35/00 ,  C12N15/86

CPC分类号： A61K48/005 ,  A61K38/45 ,  A61K45/06 ,  A61P35/00 ,  C12N15/86 ,  C12Y207/07 ,  C12N2710/24132 ,  C12N2710/24143

摘要： A method of constitutively expressing a bacterial dinucleotide cyclase in a mammalian cell is provided. The method comprises transfecting the mammalian cell with a transgene encoding the bacterial dinucleotide cyclase and subjecting the mammalian cell to suitable growth conditions. In an embodiment, the bacterial dinucleotide cyclase is expressed in a tumour or cancer cell and is useful to treat cancer.

公开(公告)号：US11896657B2

公开(公告)日：2024-02-13

申请号：US17584231

申请日：2022-01-25

申请人： GeoVax, Inc.

发明人： Harriet Robinson ,  Arban Domi ,  Michael Hellerstein

IPC分类号： A61K39/12 ,  C12N15/863 ,  C12N15/86 ,  A61K39/00

CPC分类号： A61K39/12 ,  C12N15/86 ,  C12N15/863 ,  A61K2039/5256 ,  A61K2039/5258 ,  C12N2710/24141 ,  C12N2710/24143 ,  C12N2760/10034 ,  C12N2760/14134 ,  C12N2760/14234

摘要： The compositions and methods are described for generating an immune response to a hemorrhagic fever virus such as ebolavirus, Marburgvirus, or arenavirus. The compositions and methods described herein relate to a modified vaccinia Ankara (MVA) vector encoding one or more viral antigens for generating a protective immune response to a member of genus Ebolavirus (such as a member of species Zaire ebolavirus), a member of genus Marburgvirus (such as a member of species Marburg marburgvirus), or a member of genus Arenavirus (such as a member of species Lassa virus) in the subject to which the vector is administered. The compositions and methods of the present invention are useful both prophylactically and therapeutically and may be used to prevent and/or treat an infection caused by ebolavirus, Marburgvirus, or arenavirus.

公开(公告)号：US20240024437A1

公开(公告)日：2024-01-25

申请号：US18147627

申请日：2022-12-28

申请人： Transgene SA

发明人： Philippe SLOS ,  Julie Hortelano ,  Karola Rittner ,  Xavier Preville

IPC分类号： A61K39/00 ,  C07K16/28 ,  A61K38/20 ,  A61K38/17 ,  A61K38/19 ,  A61K39/12 ,  A61K35/761 ,  A61K39/395 ,  C07K16/30 ,  C12N7/00

CPC分类号： A61K39/0011 ,  C07K16/2818 ,  A61K39/00 ,  A61K38/2013 ,  A61K38/1709 ,  A61K38/193 ,  A61K39/12 ,  A61K35/761 ,  A61K39/00117 ,  A61K39/39558 ,  C07K16/3046 ,  C12N7/00 ,  A61K2039/5256 ,  C12N2710/24143 ,  C12N2710/24171 ,  A61K2039/505 ,  C07K2317/76 ,  C07K2317/73 ,  A61K2039/55533 ,  A61K2039/575

摘要： The present invention relates to a combination product, composition(s) and kit of parts comprising at least (i) a therapeutic vaccine and (ii) one or more immune checkpoint modulator(s). The present invention also concerns a method for treating a proliferative or an infectious disease as well as a method for eliciting or stimulating and/or re-orienting an immune response, wherein said methods comprise administering to a subject in need thereof said combination product or said composition(s).

公开(公告)号：US11801299B2

公开(公告)日：2023-10-31

申请号：US17368761

申请日：2021-07-06

申请人： Georgia State University Research Foundation Inc.

发明人： Farshad Guirakhoo ,  Arban Domi ,  Nathanael P. McCurley ,  Rahul Basu ,  Ming Luo

IPC分类号： A61K39/29 ,  A61P31/14 ,  A61K39/12 ,  A61K39/295 ,  A61K9/00 ,  A61K39/00

CPC分类号： A61K39/29 ,  A61K9/006 ,  A61K9/0019 ,  A61K39/12 ,  A61P31/14 ,  A61K39/295 ,  A61K2039/57 ,  C12N2710/24143 ,  C12N2730/10123 ,  C12N2730/10134

摘要： The compositions and methods are described for generating an immune response to a hepatitis B virus. The compositions and methods described herein relate to a modified vaccinia Ankara (MVA) vector encoding one or more viral antigens for generating a protective immune response to a hepatitis B virus, in the subject to which the vector is administered. The compositions and methods of the present invention are useful both prophylactically and therapeutically and may be used to prevent and/or treat an infection caused by hepatitis B virus.

公开(公告)号：US20230313148A1

公开(公告)日：2023-10-05

申请号：US17995969

申请日：2021-04-16

申请人： Roslin Technologies Limited

发明人： Patrick Joe Mee ,  Melany Jackson ,  Ryan Taylor

IPC分类号： C12N5/074 ,  C12N15/86

CPC分类号： C12N5/0696 ,  C12N15/86 ,  C12N2506/08 ,  C12N2501/603 ,  C12N2501/606 ,  C12N2710/24143

摘要： A method of inducing pluripotency in somatic cells derived from a non-human domestic animal or farm animal comprises culturing neural stem cells (NSCs) in the presence of vectors that express one or more reprogramming factors. Canine, porcine and bovine iPSCs are obtained with distinct genetic marker profiles.

公开(公告)号：US20190184011A1

公开(公告)日：2019-06-20

申请号：US16223400

申请日：2018-12-18

申请人： Janssen Sciences Ireland Unlimited Company ,  Bavarian Nordic A/S

发明人： Daniel BODEN ,  Helen HORTON ,  Jean-Marc Edmond Fernand Marie NEEFS ,  Soumitra ROY ,  Jerôme Hubertina Henricus Victor CUSTERS ,  Roland Christian ZAHN ,  Markus KALLA

IPC分类号： A61K39/29 ,  C12N15/86

CPC分类号： A61K39/292 ,  C12N15/86 ,  C12N2710/24143 ,  C12N2730/10134

摘要： Provided herein are Modified Vaccinia Ankara (MVA) vectors and adenovirus vectors encoding HBV antigens. Also provided are methods of enhancing an immune response in a human subject by utilizing the MVA and adenovirus vectors encoding HBV antigens in a prime/boost regimen to the enhance the immune response in the human subject.

公开(公告)号：US20180303930A1

公开(公告)日：2018-10-25

申请号：US15919110

申请日：2018-03-12

申请人： CITY OF HOPE

发明人： Don J. DIAMOND ,  Felix WUSSOW

IPC分类号： A61K39/245 ,  A61K39/12

CPC分类号： A61K39/245 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/16122 ,  C12N2710/16134 ,  C12N2710/24143 ,  C12N2799/023 ,  C12N2800/204

摘要： In one embodiment, an expression system for expressing a UL128 complex is provided herein. The expression system may include a bacterial artificial chromosome (BAC) construct, wherein the BAC construct comprises a viral vector inserted with a set of DNA sequences that encode a UL128 complex. In another embodiment, a vaccine composition for preventing HCMV infection is provided. The vaccine composition may include a viral or bacterial vector capable of expressing a UL128 complex and a pharmaceutically acceptable carrier, adjuvant, additive or combination thereof or additional vector expressing a protein adjuvant. The viral vector may be an MVA and the UL128 complex includes five HCMV proteins or antigenic fragments thereof: UL128, UL130, UL131A, gL, and gH. In some embodiments, the viral vector is further inserted with one or more additional DNA sequences that encode one or more additional HCMVHCMV proteins or antigenic fragments thereof such as pp65, gB or both, or such as gM/gN or gO.

公开(公告)号：US20180271921A1

公开(公告)日：2018-09-27

申请号：US15758689

申请日：2016-09-02

申请人： SillaJen, Inc.

发明人： Tae Ho HWANG ,  Nam Hee LEE ,  Euna CHO

IPC分类号： A61K35/768 ,  C12N9/18 ,  C07K14/565 ,  A61K38/46 ,  A61K38/21 ,  A61K45/06 ,  A61P35/00

CPC分类号： A61K35/768 ,  A61K31/282 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/519 ,  A61K31/7068 ,  A61K38/215 ,  A61K38/465 ,  A61K45/06 ,  A61K48/005 ,  A61P35/00 ,  C07K14/52 ,  C07K14/565 ,  C12N9/18 ,  C12N2710/24132 ,  C12N2710/24134 ,  C12N2710/24141 ,  C12N2710/24143 ,  C12Y301/01001 ,  A61K2300/00

摘要： The present disclosure pertains to a compositions and combinations for simultaneous, separate or sequential use which comprises (a) an oncolytic vaccinia virus that expresses a cytokine and a carboxylesterase enzyme, and, preferably, (b) a cancer co-drug, and to their uses for the treatment of cancer.

公开(公告)号：US09821046B2

公开(公告)日：2017-11-21

申请号：US14762106

申请日：2014-01-21

申请人： OXFORD UNIVERSITY INNOVATION LIMITED

发明人： Katharine Alice Collins ,  Sarah Catharine Gilbert ,  Adrian Vivian Sinton Hill

IPC分类号： A61K39/15 ,  C07K14/445 ,  A61K39/015 ,  A61K39/12 ,  A61K38/16 ,  C07K16/08 ,  C07K16/20 ,  C12N7/00 ,  A61K39/00

CPC分类号： A61K39/015 ,  A61K38/162 ,  A61K39/12 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/5256 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55577 ,  A61K2039/70 ,  C07K14/445 ,  C07K16/082 ,  C07K16/205 ,  C07K2319/00 ,  C07K2319/40 ,  C12N7/00 ,  C12N2710/10041 ,  C12N2710/24121 ,  C12N2710/24134 ,  C12N2710/24141 ,  C12N2710/24143 ,  C12N2710/24171 ,  C12N2730/10134 ,  C12N2730/10171 ,  Y02A50/412

摘要： The present invention provides a particle comprising a fusion protein, wherein the fusion protein comprises at least one NANP repeat (SEQ ID NO: 7), some or all of the C-terminus of the CS protein from Plasmodium falciparum and a hepatitis B surface antigen, and wherein the particle comprises no, or substantially no, free hepatitis B surface antigen protein, and uses thereof.

公开(公告)号：US20170319685A1

公开(公告)日：2017-11-09

申请号：US15461336

申请日：2017-03-16

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Richard Syd Kornbluth ,  Geoffrey William Stone

IPC分类号： A61K39/39 ,  C07K14/005 ,  A61K35/763 ,  C12N15/86 ,  C07K14/705 ,  A61K39/00

CPC分类号： A61K39/39 ,  A61K35/763 ,  A61K2039/5256 ,  A61K2039/55516 ,  C07K14/005 ,  C07K14/70578 ,  C07K2319/03 ,  C12N15/86 ,  C12N2710/16222 ,  C12N2710/16632 ,  C12N2710/24143 ,  C12N2740/15011 ,  C12N2740/16011

摘要： The present invention is drawn to compositions and methods to enhance an immune response in order to prevent or treat infections or hyperproliferative diseases such as cancer. More particularly, the composition is an immunostimulatory intracellular signaling peptide fused directly or indirectly to a peptide that leads to multimerization into complexes of three or more units, where the intracellular signaling peptide must be present in a complex of three or more units in order to stimulate an immune response. Inserting this fusion construct into viruses like HIV-1 or introducing it into dendritic cells or tumor cells is predicted to lead to a positive therapeutic effect in humans, non-human mammals, birds, and fish.