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公开(公告)号：US20210268104A1
公开(公告)日：2021-09-02
申请号：US17323082
申请日：2021-05-18
发明人： Daniel BODEN , Helen HORTON , Jean-Marc Edmond Fernand Marie NEEFS , Soumitra ROY , Jerôme Hubertina Henricus Victor CUSTERS , Roland Christian ZAHN , Markus KALLA
摘要： Provided herein are Modified Vaccinia Ankara (MVA) vectors and adenovirus vectors encoding HBV antigens. Also provided are methods of enhancing an immune response in a human subject by utilizing the MVA and adenovirus vectors encoding HBV antigens in a prime/boost regimen to the enhance the immune response in the human subject.
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2.发明申请公开(公告)号：US20190184011A1
公开(公告)日：2019-06-20
申请号：US16223400
申请日：2018-12-18
发明人： Daniel BODEN , Helen HORTON , Jean-Marc Edmond Fernand Marie NEEFS , Soumitra ROY , Jerôme Hubertina Henricus Victor CUSTERS , Roland Christian ZAHN , Markus KALLA
CPC分类号： A61K39/292 , C12N15/86 , C12N2710/24143 , C12N2730/10134
摘要： Provided herein are Modified Vaccinia Ankara (MVA) vectors and adenovirus vectors encoding HBV antigens. Also provided are methods of enhancing an immune response in a human subject by utilizing the MVA and adenovirus vectors encoding HBV antigens in a prime/boost regimen to the enhance the immune response in the human subject.
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公开(公告)号：US20220305108A1
公开(公告)日：2022-09-29
申请号：US17596839
申请日：2020-06-19
发明人： Helen HORTON , Ian STRICKLAND , Daniel BODEN
摘要： Pharmaceutical compositions containing hepatitis B virus (HBV) vaccines and lipids are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed pharmaceutical compositions are also described.
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公开(公告)号：US20220305118A1
公开(公告)日：2022-09-29
申请号：US17596862
申请日：2020-06-19
发明人： Helen HORTON , Ian STRICKLAND , Daniel BODEN
IPC分类号： A61K39/385 , A61K39/39 , A61K39/12 , A61P31/20 , C12N7/00
摘要： Pharmaceutical compositions containing hepatitis B virus (HBV) vaccines and carbohydrate polymers are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed pharmaceutical compositions are also described.
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公开(公告)号：US20220226467A1
公开(公告)日：2022-07-21
申请号：US17596750
申请日：2020-06-18
发明人： Helen HORTON , Daniel BODEN
摘要： Arenavirus vectors encoding hepatitis B virus (HBV) vaccines are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed arenavirus vectors are also described.
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公开(公告)号：US20210269778A1
公开(公告)日：2021-09-02
申请号：US17324494
申请日：2021-05-19
IPC分类号： C12N9/12 , A61P31/20 , C07K14/005 , A61K39/12
摘要： Polynucleotides encoding hepatitis B virus (HBV) core antigen and polymerase antigen, and related combinations are described. Also described are vectors, such as DNA plasmids or viral vectors, expressing the HBV core and polymerase antigens, and immunogenic compositions containing the expression vectors. Methods of inducing an immune response against HBV or treating a HBV-induced disease, particularly in individuals having chronic HBV infection, using the immunogenic compositions are also described.
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公开(公告)号：US20220313815A1
公开(公告)日：2022-10-06
申请号：US17596874
申请日：2020-06-19
发明人： Helen HORTON , Daniel BODEN
摘要： Self-replicating RNA molecules encoding hepatitis B virus (HBV) vaccines are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed self-replicating RNA molecules are also described. Kits comprising the disclosed self-replicating RNA molecules are also described.
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