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    NON-INVASIVE SYSTEMS AND METHODS FOR IN-SITU PHOTOBIOMODULATION
    9.
    发明申请
    NON-INVASIVE SYSTEMS AND METHODS FOR IN-SITU PHOTOBIOMODULATION 审中-公开
    非入侵系统和用于现场光电转换的方法

    公开(公告)号：US20160325111A1

    公开(公告)日：2016-11-10

    申请号：US15151642

    申请日：2016-05-11

    申请人： IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

    发明人： Frederic A. BOURKE, JR. ,  Tuan VO-DINH ,  Harold WALDER

    IPC分类号： A61N5/06 ,  A61N5/02 ,  A61N5/10 ,  A61K41/00 ,  A61K47/48

    CPC分类号： A61N5/062 ,  A61K41/0057 ,  A61K41/0061 ,  A61K47/6923 ,  A61N5/022 ,  A61N5/0618 ,  A61N5/0622 ,  A61N5/10 ,  A61N2005/0642 ,  A61N2005/0659 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/1098

    摘要： Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

    摘要翻译： 用于修饰介导或与生物活性相关的靶结构的产物，组合物，系统和方法，包括治疗由病毒，细胞，亚细胞结构介导或与靶结构相关的疾病，病症或疾病 或胞外结构。 所述方法可以通过向受试者施加起始能量以非侵入性方式原位进行，从而直接或经由调节剂产生对靶结构的作用或改变。 所述方法还可以通过向受试者原位施加引发能量来直接或经由能量调节剂活化药剂，任选地在存在一种或多种等离子体激元活性剂的情况下进行，从而产生效果或改变 目标结构。 包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。

    5-aminolevulinic acid prodrugs for use in photodynamic therapy and photodynamic diagnosis
    10.
    发明授权
    5-aminolevulinic acid prodrugs for use in photodynamic therapy and photodynamic diagnosis 有权
    用于光动力学治疗和光动力学诊断的5-氨基乙酰丙酸前药

    公开(公告)号：US09371275B2

    公开(公告)日：2016-06-21

    申请号：US14077469

    申请日：2013-11-12

    申请人： Swedish Pharma AB

    发明人： Leif A. Eriksson ,  Lennart Löfgren

    IPC分类号： C07C271/22 ,  C07D317/30 ,  A61K45/06 ,  A61K31/22 ,  A61K31/357 ,  C07C251/00 ,  A61K31/27 ,  A61K31/325 ,  A61K41/00 ,  C07C251/06 ,  C07C251/38

    CPC分类号： C07C271/22 ,  A61K31/22 ,  A61K31/27 ,  A61K31/325 ,  A61K31/357 ,  A61K41/0061 ,  A61K45/06 ,  C07C251/00 ,  C07C251/06 ,  C07C251/38 ,  C07D317/30

    摘要： There is provided a compound of Formula (I) and salts thereof, where R1 is an oxime or an alkylated oxime; the alkylated oxime comprises a linear or branched alkyl group of length C1 to C5; and R2 are each independently (a) an unsubstituted or substituted linear or branched alkyl group of chain length C1-7, (b) an aryl substituted alkyl group, where the aryl group is substituted, (c) an alkoxy substituted alkyl group, where the alkoxy group is substituted by a methoxy group or an alkoxy group substituted with an alkoxy group, or (d) an H atom, where the substituents in (a) and (b) are hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, nitro, oxo or fluoro groups. The compounds may be used as a medicament.

    摘要翻译： 提供式（I）的化合物及其盐，其中R 1是肟或烷基化的肟; 烷基化肟包含长度为C1至C5的直链或支链烷基; 和（R 2）各自独立地为（a）未取代或取代的链长C 1-7的直链或支链烷基，（b）芳基取代的烷基，其中芳基被取代，（c）烷氧基取代的烷基，其中 烷氧基被甲氧基或被烷氧基取代的烷氧基取代，或（d）H原子，其中（a）和（b）中的取代基是羟基，烷氧基，酰氧基，烷氧基羰氧基，氨基，芳基 ，硝基，氧代或氟基团。 这些化合物可以用作药物。